Sodium thiosulfate is a Medicine belongs to Chelaators group whose information about Brand can be referenced from   Book : Martindale    Page : 1608   Edition : 37,

  ►   Brandname : Histaglobulin,Cyanide Antidote Package,Tinver,Versiclear

  ►  Strength : Injection with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1608   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1608   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cyanide poisoning IV 12.5 gm Injection 300 mg of sodium nitrite (10 mL of a 3% solution) given intravenously over 5 to 20 minutes followed by 12.5 g of sodium thiosulfate (50 mL of a 25% solution or 25 mL of a 50% solution) given intravenously over a period of about 10 minutes.

Ref :-  Book : Martindale    Page : 1576   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cyanide poisoning 1 Month 18 Year IV 400 mg/kg Injection

Ref :- Book : Martindale    Page : 1576   Edition : 38,
►  Side Effect : osmotic disturbances,
Ref :-   Book : Martindale    Page : 1608   Edition : 37,

►  Drug Interaction : Drug interaction of Sodium thiosulfate is with NA

  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : pregnancy, hepatic cirrhosis, renal impairment,
Ref :-   Book : Martindale    Page : 1576   Edition : 38,
  ►  Mechanism of Action :   Sodium thiosulfate acts as sulfur donor for the enzyme rhodanese, catalyses the conversion of cyanide to relatively non-toxic thiocyanate and thus accelerates the detoxification of cyanide. ,
Ref :-   Book : Martindale    Page : 1606   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1576   Edition : 38,


►    Plasma Half-life :
  Min value :-   0.33 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1576   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,