Somatropin is a Medicine belongs to Growth hormone group whose information about Brand can be referenced from   Book : Martindale    Page : 1960   Edition : 37,

  ►   Brandname : Saizen,GenotRopin,Humatrope,Norditropin,Nutropin,Omnitrope,Protropin

  ►  Strength : Injection with 0.2-24  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 675   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IM,
Reference :-   Book : Martindale    Page : 1958   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Growth Hormone deficiency SC 6 micrograms/kg Injection Daily.
2 Turner syndrome SC 45 50 micrograms/kg Injection Daily.
3 Cachexia SC 100 micrograms/kg Injection h.s.
4 Short bowel syndrome SC 100 micrograms/kg Injection Daily.

Ref :-  Book : Martindale    Page : 1920   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Growth Hormone deficiency SC 25 35 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1920   Edition : 38,
►  Side Effect : redness, Itching, lumps, lipoatrophy or lipohypertrophy at injection site, peripheral oedema, carpal tunnel syndrome, headache, joint pains, muscle pain, paraesthesia, intracranial hypertension, diabetogenic effect, hypoglycemia, Hyperglycaemia, Ear disorder, hypersenstivity, acute pancreatitis,
Ref :-   Book : Martindale    Page : 1957   Edition : 37,

►  Drug Interaction : Drug interaction of Somatropin is with Corticosteroids, oestrogen,
Ref :-   Book : Martindale    Page : 1958   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  High doses of corticosteroids may inhibit the growth promoting effects of growth hormone. Doses of growth hormone may need to be increased in women receiving oral oestrogen replacement therapy, and may require adjustment if the route of oestrogen administration is changed. ,
Ref :-   Book : Martindale    Page : 1958   Edition : 37,


►  Contraindication : active neoplasms, intracranial lesions, diabetic retinopathy,
Ref :-   Book : Martindale    Page : 1958   Edition : 37,
  ►  Mechanism of Action :   Recombinant form of human GH- act through GH receptor to increase production of IGF-I,
Ref :-   Book : Basic & Clinical pharmacology    Page : 675   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1958   Edition : 37,


►    Plasma Half-life :
  Min value :-   0.33 hours,    Max value :-   0.41 hours,
Ref :-   Book : Martindale    Page : 1958   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Basic & Clinical pharmacology    Page : 678   Edition : 12,