Sorafenib is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 850   Edition : 37,

  ►   Brandname : Nexavar,Soranib

  ►  Strength : Tablet with 200  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 850   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 850   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Renal cell carcinoma Oral 400 mg Tablet b.d. At least 1 hour before or 2 hours after food.

Ref :-  Book : Martindale    Page : 857   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bleeding, hypertension, arterial thromboembolic events, Dermatological toxicities, palmar-plantar syndrome, Rashes,
Ref :-   Book : Martindale    Page : 850   Edition : 37,

►  Drug Interaction : Drug interaction of Sorafenib is with flowering plant,  Rifampicin , Carbamazapine , Dexamethasone , Phenobarbital , Phenytoin , Docetaxel, Doxorubicin, Irinotecan, Fluorouracil , Warfarin , Phenprocoumon,
Ref :-   Book : Martindale    Page : 850.1   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Sorafenib is metabolised by the cytochrome P450 isoenzyme CYP3A4. Rifampicin can reduce exposure to sorafenib. Other inducers of this enzyme (such as carbamazepine, dexamethasone, St John’s wort, phenobarbital, and phenytoin) may also reduce blood concentrations of sorafenib. Sorafenib inhibits the cytochrome P450 isoenzyme CYP2C9 in vitro, and may increase concentrations of its substrates. The effect of warfarin on mean PT-INR was not altered by sorafenib; however, patients taking warfarin or phenprocoumon with sorafenib should have their INR regularly checked Sorafenib also inhibits the isoenzymes CYP2B6 and CYP2C8 in vitro, and drug interactions with substrates of these may occur. Sorafenib may increase exposure to docetaxel, doxorubicin, and irinotecan; variable effects on fluorouracil have been reported,
Ref :-   Book : Martindale    Page : 850   Edition : 37,


►  Contraindication : cardiac infarction, cardiac ischaemia ,
Ref :-   Book : Martindale    Page : 850   Edition : 37,
  ►  Mechanism of Action :   Sorafenib is an inhibitor of multiple intracellular and cell surface kinases thought to be involved in angiogenesis.,
Ref :-   Book : Martindale    Page : 850   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 850   Edition : 37,


►    Plasma Half-life :
  Min value :-   20 hours,    Max value :-   27 hours,
Ref :-   Book : Martindale    Page : 850   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 850   Edition : 37,