Sotalol is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1536   Edition : 37  

  ►   Brandname : Beta-Cardone, Sotacor, Betapace, Cardol, Solavert, Sotacor, CorSotalol, Darob
  ►  Strength : Tablet with 80 Mg.  Tablet with 120 Mg.  Tablet with 160 mg.  Tablet with 240 mg.  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 167   Edition : 12   Martindale    Page : 1535   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Martindale    Page : 1535   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Angina pectoris Oral 80 mg Tablet b.d. This should not be increased for at least 3 days. Most patients respond to doses of 160 to 320 mg daily (usually given in two divided doses). Some patients with ventricular arrhythmias may require doses as high as 640 mg daily.
2 Acute arrhythmias IV 20 120 mg Injection (500 to 1500 micrograms/kg) intravenously over 10 minutes. This dose may be repeated every 6 hours if necessary. To substitute for oral therapy an intravenous infusion of 200 to 500 micrograms/kg per hour may be used. The total daily dose should not exceed 640 mg.

Ref :-  Book : Martindale    Page : 1335   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Supraventricular arrhythmias Oral 1 mg/kg Tablet b.d.
2 Supraventricular arrhythmias 1 Month 12 Year Oral 1 mg/kg Tablet b.d.

Ref :- Book : Martindale    Page : 1535   Edition : 37  
►  Side Effect : Torsade de pointes, Heart failure, Heart block, Bronchospasm, Coldness of the extremities, Bradycardia, Hypotension, Shortness of breath, Dyspnoea, Pneumonitis, Pulmonary fibrosis, Pleurisy, Headache, Depression, Dizziness, Hallucinations, Confusion, Amnesia, Sleep disturbances, Nightmares, Coma, Convulsions, Fatigue, Paraesthesia, Arthralgia, Myopathies, Muscle cramps, Raynaud’s syndrome, Nausea, Vomiting, Diarrhoea, Constipation, Abdominal cramping, Hypoglycaemia, Hyperglycaemia, Changes in blood concentrations of triglycerides and cholesterol, Rashes, Pruritus, Exacerbation of psoriasis, Excess sweating, Reversible alopecia, Blurred Vision, Conjunctivitis, Soreness, Nonthrombocytopenic purpura, Thrombocytopenia, Transient eosinophilia, Systemic lupus erythematous (SLE), Dry mouth, Raised liver enzymes, impotence, Sclerosing peritonitis, Retroperitoneal fibrosis
Ref :-   Book : Martindale    Page : 1349, 1335   Edition : 37.  

►  Drug Interaction : Drug interaction of Sotalol is with Tricyclic antidepressants, , Quinolones,  Disopyramide , Procainamide , Quinidine , Amiodarone , Phenothiazine, Astemizole, Terfenadine, Cisapride , Erythromycin , Halofantrine, Pentamidine , Sultopride, Vincamine
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of precipitating ventricular arrhythmias if sotalol is given with other drugs that prolong the QT interval, and use with the following drugs is therefore not recommended: class Ia antiarrhythmics (including disopyramide, procainamide, and quinidine), amiodarone, phenothiazine antipsychotics, tricyclic antidepressants, certain antihistamines (astemizole or terfenadine), cisapride, erythromycin, halofantrine, pentamidine, quinolones, sultopride, and vincamine. Caution is required if sotalol is given with drugs that cause electrolyte disturbances, such as diuretics, since this also increases the risk of arrhythmias.
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  


►  Contraindication : Bronchospasm, Asthma, Metabolic acidosis, Cardiogenic shock, Hypotension, Severe peripheral arterial disease, Sinus bradycardia, Second -or- third degree AV block, Uncontrolled heart failure, Hyperthyroidism, Hypoglycaemia, Prinzmetal angina, Severity of anaphylactoid reactions, Pregnancy, Phaeochromocytoma should not be given beta blockers without alpha-adrenoceptor blocking therapy as well
Ref :-   Book : Martindale    Page : 1351, 1335   Edition : 37.  
  ►  Mechanism of Action :   Block K+ channels, resulting in longer action potential plateau and prolonged repolarization.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 420   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  

►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   20 hours.  
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours.  
Ref :-   Book : Martindale    Page : 1535   Edition : 37.