Sotalol is a Medicine belongs to Beta Blockers group whose information about Brand can be referenced from   Book : Martindale    Page : 1536   Edition : 37,

  ►   Brandname :
Beta-Cardone,Sotacor,Betapace


  ►  Strength :
Tablet with 80  Mg, Tablet with 120  Mg, Tablet with 160  mg, Tablet with 240  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 167   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
Oral, IV,
Reference :-   Book : Martindale    Page : 1535   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Angina pectoris Oral 80 mg Tablet Daily.
2 Arrhythmia IV 20 120 mg Injection Over 10 minutes.

Ref :-  Book : Martindale    Page : 1498   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Supraventricular arrhythmias > 1 Day > 28 Day Oral 1 mg/kg Tablet b.d.
2 Supraventricular arrhythmias 1 Month 12 Year Oral 1 mg/kg Tablet b.d.

Ref :- Book : Martindale    Page : 1498   Edition : 38,
►  Side Effect :
torsade de pointes, heart failure, heart block, bronchospasm, fatigue, coldness of the extremities, hypertension, hypotension, headache, bradycardia, Depression, Dizziness, hallucinations, Confusion, amnesia, Sleep disturbances, nightmares, convulsion, paraesthesia, arthralgia, myopathies, muscle cramp, nausea, vomiting, diarrhea, constipation, abdominal cramp, hypoglycemia, Hyperglycaemia, changes in blood concentrations of triglycerides and cholesterol, Skin rashes, pruritus, exacerbation of psoriasis, excess sweating, reversible alopecia, Decreased tear production, Blurred Vision, conjunctivitis, soreness, nonthrombocytopenic purpura, thrombocytopenia, agranulocytosis, transient eosinophilia,
Ref :-   Book : Martindale    Page : 1349, 1535   Edition : 37,
►  Drug Interaction : Drug interaction of Sotalol is with
Disopyramide , Procainamide , Quinidine , Amiodarone , Phenothiazine, , Bevacizumab , Cisapride , Erythromycin , Halofantrine, Pentamidine , Glipizide , Sultopride, Vincamine,
Ref :-   Book : Martindale    Page : 1535   Edition : 37,

  ►    Mechanism of Drug Drug Interaction : 
There is an increased risk of precipitating ventricular arrhythmias if sotalol is given with other drugs that prolong the QT interval, and use with the following drugs is therefore not recommended: class Ia antiarrhythmics (including disopyramide, procainamide, and quinidine), amiodarone, phenothiazine antipsychotics, tricyclic antidepressants, certain antihistamines (astemizole or terfenadine), cisapride, erythromycin, halofantrine, pentamidine, quinolones, sultopride, and vincamine.,
Ref :-   Book : Martindale    Page : 1535   Edition : 37,

►  Contraindication :
prolonged QT interval , renal impairment,
Ref :-   Book : Martindale    Page : 1535   Edition : 38,
  ►  Mechanism of Action :  
Block K+ channels, resulting in longer action potential plateau and prolonged repolarization. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 420   Edition : 3,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions

​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :  
Renal,
Ref :-   Book : Martindale    Page : 1535   Edition : 37,

►    Plasma Half-life :  
Min value :-   10 hours,    Max value :-   20 hours,
Ref :-   Book : Martindale    Page : 1535   Edition : 37,

►    Peak Plasma Concentration :  
Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 1535   Edition : 37,