Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Angina pectoris	Oral	80		mg	Tablet	b.d.	This should not be increased for at least 3 days. Most patients respond to doses of 160 to 320 mg daily (usually given in two divided doses). Some patients with ventricular arrhythmias may require doses as high as 640 mg daily.
2	Acute arrhythmias	IV	20	120	mg	Injection		(500 to 1500 micrograms/kg) intravenously over 10 minutes. This dose may be repeated every 6 hours if necessary. To substitute for oral therapy an intravenous infusion of 200 to 500 micrograms/kg per hour may be used. The total daily dose should not exceed 640 mg.

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Angina pectoris	Oral	80		mg	Tablet	b.d.	This should not be increased for at least 3 days. Most patients respond to doses of 160 to 320 mg daily (usually given in two divided doses). Some patients with ventricular arrhythmias may require doses as high as 640 mg daily.
2	Acute arrhythmias	IV	20	120	mg	Injection		(500 to 1500 micrograms/kg) intravenously over 10 minutes. This dose may be repeated every 6 hours if necessary. To substitute for oral therapy an intravenous infusion of 200 to 500 micrograms/kg per hour may be used. The total daily dose should not exceed 640 mg.

Ref :-  Book : Martindale    Page : 1335   Edition : 37  

Pediatric Dose

Ref :- Book : Martindale    Page : 1535   Edition : 37  

►  Side Effect : Torsade de pointes, Heart failure, Heart block, Bronchospasm, Coldness of the extremities, Bradycardia, Hypotension, Shortness of breath, Dyspnoea, Pneumonitis, Pulmonary fibrosis, Pleurisy, Headache, Depression, Dizziness, Hallucinations, Confusion, Amnesia, Sleep disturbances, Nightmares, Coma, Convulsions, Fatigue, Paraesthesia, Arthralgia, Myopathies, Muscle cramps, Raynaud’s syndrome, Nausea, Vomiting, Diarrhoea, Constipation, Abdominal cramping, Hypoglycaemia, Hyperglycaemia, Changes in blood concentrations of triglycerides and cholesterol, Rashes, Pruritus, Exacerbation of psoriasis, Excess sweating, Reversible alopecia, Blurred Vision, Conjunctivitis, Soreness, Nonthrombocytopenic purpura, Thrombocytopenia, Transient eosinophilia, Systemic lupus erythematous (SLE), Dry mouth, Raised liver enzymes, impotence, Sclerosing peritonitis, Retroperitoneal fibrosis
Ref :-   Book : Martindale    Page : 1349, 1335   Edition : 37.  
►  Drug Interaction : Drug interaction of Sotalol is with Tricyclic antidepressants, , Quinolones,  Disopyramide , Procainamide , Quinidine , Amiodarone , Phenothiazine, Astemizole, Terfenadine, Cisapride , Erythromycin , Halofantrine, Pentamidine , Sultopride, Vincamine
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  

Drug interaction

Drug Interaction : Drug interaction of Sotalol is with Tricyclic antidepressants, , Quinolones,  Disopyramide , Procainamide , Quinidine , Amiodarone , Phenothiazine, Astemizole, Terfenadine, Cisapride , Erythromycin , Halofantrine, Pentamidine , Sultopride, Vincamine

Book : Martindale    Page : 1535   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of precipitating ventricular arrhythmias if sotalol is given with other drugs that prolong the QT interval, and use with the following drugs is therefore not recommended: class Ia antiarrhythmics (including disopyramide, procainamide, and quinidine), amiodarone, phenothiazine antipsychotics, tricyclic antidepressants, certain antihistamines (astemizole or terfenadine), cisapride, erythromycin, halofantrine, pentamidine, quinolones, sultopride, and vincamine. Caution is required if sotalol is given with drugs that cause electrolyte disturbances, such as diuretics, since this also increases the risk of arrhythmias.
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  

Mechanism of Drug

Mechanism of Drug Drug Interaction : There is an increased risk of precipitating ventricular arrhythmias if sotalol is given with other drugs that prolong the QT interval, and use with the following drugs is therefore not recommended: class Ia antiarrhythmics (including disopyramide, procainamide, and quinidine), amiodarone, phenothiazine antipsychotics, tricyclic antidepressants, certain antihistamines (astemizole or terfenadine), cisapride, erythromycin, halofantrine, pentamidine, quinolones, sultopride, and vincamine. Caution is required if sotalol is given with drugs that cause electrolyte disturbances, such as diuretics, since this also increases the risk of arrhythmias.

Book : Martindale    Page : 1535   Edition : 37.  

►  Contraindication : Bronchospasm, Asthma, Metabolic acidosis, Cardiogenic shock, Hypotension, Severe peripheral arterial disease, Sinus bradycardia, Second -or- third degree AV block, Uncontrolled heart failure, Hyperthyroidism, Hypoglycaemia, Prinzmetal angina, Severity of anaphylactoid reactions, Pregnancy, Phaeochromocytoma should not be given beta blockers without alpha-adrenoceptor blocking therapy as well
Ref :-   Book : Martindale    Page : 1351, 1335   Edition : 37.  

  ►  Mechanism of Action :   Block K+ channels, resulting in longer action potential plateau and prolonged repolarization.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 420   Edition : 3.  

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  
►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   20 hours.  
Ref :-   Book : Martindale    Page : 1535   Edition : 37.  
►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours.  
Ref :-   Book : Martindale    Page : 1535   Edition : 37.