Spiramycin is a Medicine belongs to MACROLIDES group whose information about Brand can be referenced from   Book : Martindale    Page : 359   Edition : 38,

  ►   Brandname : Rovamycin

  ►  Strength : Tablet with nf  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal, IV,
Reference :-   Book : Martindale    Page : 362   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe infections Oral 6 9 million units Tablet Daily, in 2 or 3 divided doses.
2 Severe infections IV infusion 1.5 million units Injection t.i.d.

Ref :-  Book : Martindale    Page : 358   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : gastrointestinal disturbance, Smell disturbances, taste disturbances, stomatitis, glossitis, Tongue discoloration, tooth discoloration, headache, transient CNS effects, arthralgia, myalgia, hypoglycemia, leucopenia, thrombocytopenia, renal failure, muscle weakness, interstitial nephritis, phlebitis, myasthenic syndrome,
Ref :-   Book : Martindale    Page : 267, 293   Edition : 38,

►  Drug Interaction : Drug interaction of Spiramycin is with Mequitazine, Levodopa ,
Ref :-   Book : Martindale    Page : 358,359*   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  piramycin is reported to have little or no effect on hepatic cytochrome P450 isoenzymes and may therefore produce fewer interactions than erythromycin or with other drugs metabolised by this enzyme system. Nevertheless, a report of torsade de pointes in a patient with a congenital long QT syndrome during treatment with spiramycin and mequitazine suggests that caution is still needed. Reduced plasma concentrations of levodopa have been reported when given with spiramycin. ,
Ref :-   Book : Martindale    Page : 358-359   Edition : 38,


►  Contraindication : Arrhythmia, Hypersensitivity, jaundice, prolonged QT interval , hepatic impairment, renal impairment, pregnancy,
Ref :-   Book : Martindale    Page : 294   Edition : 38,
  ►  Mechanism of Action :   It is a bacteriostatic agent that inhibit protein synthesis by binding reversibly to 50S ribosomal subunits of sensitive microorganisms, at or very near the site that binds chloramphenicol.,
Ref :-   Book : Goodman    Page : 1530   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 362   Edition : 37,


►    Plasma Half-life :
  Min value :-   5 hours,    Max value :-   8 hours,
Ref :-   Book : Martindale    Page : 362   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 362   Edition : 37,