Spironolactone is a Medicine belongs to Potassium -Sparing Diuretics group whose information about Brand can be referenced from   Book : Martindale    Page : 1539   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Aldactone,Spirospare,fruselac,Dytor plus,Aldacetone,lasilactone

  ►  Strength : Tablet with 25  mg, Tablet with 50  Mg, Tablet with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 270   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1538   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 100 mg Tablet Daily.
2 Hyperaldosteronism Oral 100 400 mg Tablet Daily for the preoperative management.

Ref :-  Book : Martindale    Page : 1500   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Heart failure > 1 Day > 28 Day Oral 1 2 mg/kg Tablet
2 Heart failure 1 Month 12 Year Oral 1 3 mg/kg Tablet
3 Heart failure 12 Year 18 Year Oral 50 100 mg Tablet
4 Oedema > 1 Day > 28 Day Oral 1 2 mg/kg Tablet
5 Oedema 1 Month 12 Year Oral 1 3 mg/kg Tablet
6 Oedema 12 Year 18 Year Oral 50 100 mg Tablet

Ref :- Book : Martindale    Page : 1500   Edition : 38,
Precaution :- If a Patient is using 'Spironolactone' drug in  acute kidney injury   disease, then Please be used with caution .

Precaution :- If a Patient is using 'Spironolactone' drug in  Gynecomastia  disease, then Please not be used .

►  Side Effect : headache, drowsiness, gastrointestinal disturbance, cramp, diarrhoea, ataxia, mental confusion, Skin rashes, Gynaecomastia, Hirsutism, deepening of the voice, hyponatraemia, hyperkalaemia, menstrual irregularity, breast enlargement,
Ref :-   Book : Martindale    Page : 1536   Edition : 37,

►  Drug Interaction : Drug interaction of Spironolactone is with Aspirin, Cabergoline , Sertraline, Ropivacaine , Cyclosporine , Felbamate, Warfarin ,
Ref :-   Book : Martindale    Page : 1537   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  In patients given spironolactone with NSAIDs or ciclosporin the risk of nephrotoxicity may also be increased. Diuretics may reduce the excretion of lithium and increase the risk of lithium toxicity. Hyponatraemia may occur in patients taking a potassium-sparing diuretic with a thiazide; this risk may be increased in patients given chlorpropamide. Spironolactone may reduce the ulcer-healing properties of carbenoxolone. As with other diuretics, spironolactone may enhance the effects of other antihypertensive drugs and may reduce vascular responses to noradrenaline. ,
Ref :-   Book : Martindale    Page : 1537   Edition : 37,


►  Contraindication : hepatic impairment, hyperkalaemia, renal impairment,
Ref :-   Book : Martindale    Page : 1537   Edition : 37,
  ►  Mechanism of Action :   Spironolactone, a steroid with a structure resembling that of the natural adrenocortical hormone aldosterone, acts on the distal portion of the renal tubule as a competitive antagonist of aldosterone. It acts as a potassium- sparing diuretic, increasing sodium and water excretion and reducing potassium excretion,
Ref :-   Book : Martindale    Page : 1538   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tomato with Another pathway,

  ►  Pathway with its reference as follows :-
  • Diuretic properties --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- FRANGULA I.E. RHAMNUS FRANGULA with frangula interact with carticosteroid .,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1537   Edition : 37,


    ►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1537   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,