Stanozolol is a Medicine belongs to Androgenic and anabolic steroids group whose information about Brand can be referenced from   Book : Martindale    Page : 2337   Edition : 37  

  ►   Brandname : Menabol, Neurabol, Winstro
  ►  Strength : Tablet with .  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2337   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2337   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Breast cancer in postmenopausal women, and for anaemias, osteoporosis, and catabolic disorders Oral 2 mg Tablet Given every 8 to 12 hours.
2 Breast cancer in postmenopausal women, and for anaemias, osteoporosis, and catabolic disorders IM 50 mg Injection Given every 2 or 3 weeks.
3 Hereditary angioedema Oral 1 2 mg Tablet Given daily or alternate days, and possibly less frequenty, although doses of up to 5 mg once or twice daily may be necessary.

Ref :-  Book : Martindale    Page : 2337   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Increased retention of sodium and water, oedema, hypercalcaemia, and impaired glucose tolerance., Increased lowdensity- lipoprotein cholesterol, decreased high-density- lipoprotein cholesterol, increased haematocrit, and suppression of clotting factors., Headache, Depression, Gastrointestinal bleeding, Jaundice, Cholestatic hepatitis, Peliosis hepatis and hepatic tumours in patients who have received high doses over prolonged periods., In men, large doses suppress spermatogenesis and cause testicular atrophy, Gynaecomastia may occur. Androgens may cause prostatic hyperplasia and accelerate the growth of malignant neoplasms of the prostate, In women, the inhibitory action of androgens on the activity of the anterior pituitary results in the suppression of ovarian activity and menstruation. Continued use produces symptoms of virilism, such as hirsutism or male-pattern baldness, deepening of the voice, atrophy of the breasts and endometrial tissue, oily skin, acne, and hypertrophy of the clitoris., Virilisation may not be reversible, even after stopping therapy.
Ref :-   Book : Martindale    Page : 2337, 2338   Edition : 37.  

►  Drug Interaction : Drug interaction of Stanozolol is with ,  Levofloxacin , Warfarin
Ref :-   Book : Martindale    Page : 1570,2337,2339   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Stanozolol and other androgens and anabolic steroids have been reported to enhance the activity of a number of drugs, with resulting increases in toxicity. Drugs affected include ciclosporin, levothyroxine, and anticoagulants such as warfarin. Resistance to the effects of neuromuscular blockers has also been reported. As androgens and anabolic steroids can alter glucose metabolism, doses of insulin or oral antidiabetics may need adjustment. There have been reports of steroids with anabolic or androgenic properties enhancing the activity of anticoagulants to the point of haemorrhage.
Ref :-   Book : Martindale    Page : 1570,2337,2339   Edition : 37.  


►  Contraindication : It is probably best avoided in patients with hepatic impairment, and certainly if this is severe. Haematocrit and haemoglobin concentrations should also be monitored., Stanozolol and other androgens and anabolic steroids should be used cautiously in patients with cardiovascular disorders, renal or hepatic impairment, epilepsy, migraine, diabetes mellitus or other conditions that may be aggravated by the possible fluid retention or oedema caused., They should not be given to patients with hypercalcaemia or hypercalciuria, and should be used cautiously in conditions in which there is a risk of these developing such as skeletal metastases., In men, androgens and anabolic steroids should not be given to those with carcinoma of the breast or prostate (although in women they have been used in the treatment of certain breast carcinomas., The prostate should be examined regularly during treatment., Androgens and anabolic steroids should be used with extreme care in children because of the masculinising effects and also because premature closure of the epiphyses may occur resulting in inhibited linear growth and small stature. Skeletal maturation should be monitored during therapy.
Ref :-   Book : Martindale    Page : 2337, 2338   Edition : 37.  
  ►  Mechanism of Action :   It can act as an androgen either directly, by binding to the androgen receptor, or indirectly by conversion to dihydrotestosterone, which also binds to the androgen receptor. Testosterone and dihydrotestosterone act as androgens via a single androgen receptor . The androgen receptor—officially designated NR3A—is a member of the nuclear receptor superfamily. In the absence of a ligand, the androgen receptor is located in the cytoplasm associated with a heat-shock protein complex. When testosterone or dihydrotestosterone binds to the ligand-binding domain, the androgen receptor dissociates from the heat-shock protein complex, dimerizes, and translocates to the nucleus. The dimer then binds via the DNA-binding domains to androgen response elements on certain responsive genes. The ligand-receptor complex recruits coactivators and acts as a transcription factor complex, stimulating or repressing expression of those genes.
Ref :-   Book : Martindale    Page : 1197   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA