Stavudine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1002   Edition : 37,

  ►   Brandname : Zerit,Stavir,Stavex

  ►  Strength : Capsule with 15  mg, Capsule with 20  mg, Capsule with 30  mg, Capsule with 40  mg, Capsule with 37.5  mg, Capsule with 50  Mg, Capsule with 75  mg, Capsule with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1002   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 40 mg Capsule b.d. For patients weighing 60 kg.

Ref :-  Book : Martindale    Page : 1002   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection > 1 Day 13 Day Oral 500 micrograms/kg Tablet/Capsule b.d.
2 HIV infection 14 Day > 30 kg Oral 1 mg/kg Tablet/Capsule b.d.
3 HIV infection 30 kg Oral 30 mg Tablet/Capsule b.d.

Ref :- Book : Martindale    Page : 1002   Edition : 37,
►  Side Effect : peripheral neuropathy, abdominal pain, nausea, diarrhoea, dyspepsia, fatigue, Dizziness, Depression, headache, insomnia, Sleep disturbances, pruritus, Rashes, Lactic acidosis, hepatic steatosis, lipodystrophy, central obesity, dorsocervical fat enlargement , peripheral wasting, facial wasting, breast enlargement, cushingoid appearance, convulsion, hyperlipasaemia, hypertonia, neutropenia,
Ref :-   Book : Martindale    Page : 1002   Edition : 37,

►  Drug Interaction : Drug interaction of Stavudine is with Ethambutol , Isoniazid , Phenytoin ,
Ref :-   Book : Martindale    Page : 1002.1   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The intracellular activation of stavudine and hence its antiviral effect may be inhibited by zidovudine, doxorubicin, and ribavirin. Fatal lactoacidosis in patient taking metformin. In-vivo antagonism of the antiretroviral effect of stavudine when used with zidovudine,
Ref :-   Book : Martindale    Page : 1002   Edition : 37,


►  Contraindication : pancreatitis, hepatic dysfunction, Diabetes related Neuropathy,
Ref :-   Book : Martindale    Page : 1002   Edition : 37,
  ►  Mechanism of Action :   Stavudine is converted intracellularly in stages to the triphosphate. This triphosphate halts the DNA synthesis of retroviruses, including HIV, through competitive inhibition of reverse transcriptase and incorporation into viral DNA,
Ref :-   Book : Martindale    Page : 1002   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1002   Edition : 37,


►    Plasma Half-life :
  Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,

►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1002   Edition : 37,