Streptokinase is a Medicine belongs to Thrombolytics Drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1544   Edition : 37,

  ►   Brandname : Streptase,Fibrokinase

  ►  Strength : Injection with 250000  IU, Injection with 750000  mg, Injection with 1500000  IU,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 1542   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pulmonary embolism IV 250000 units Injection Over 30 minutes.
2 Myocardial infarction IV 1.5 million units Injection As a single dose , Infused over 1 hour as soon as possible after the onset of symptoms.

Ref :-  Book : Martindale    Page : 1542   Edition : 37, Martindale    Page : 1503   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Thromboembolic disorders IV 2000 units/kg Injection
2 Thromboembolic disorders 12 Year <12 Year IV 2500 units/kg Injection

Ref :- Book : Martindale    Page : 1542   Edition : 37, Martindale    Page : 1503   Edition : 38,
Precaution :- If a Patient is using 'Streptokinase' drug in  fanconi anaemia  disease, then Please precipitates mucosal bleeding .

►  Side Effect : Haemorrhage, Rashes, bradycardia, arrhythmia, Acute renal failure, pulmonary embolism, back pain, uveitis, iritis, transient proteinura, vasculitis, raised liver enzymes, serum-sickness, anaphylactic reactions,
Ref :-   Book : Martindale    Page : 1539   Edition : 37,

►  Drug Interaction : Drug interaction of Streptokinase is with Heparin , Aspirin (Acetylsalicylic acid), Dextran,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Oral anticoagulants, heparin, and antiplatelet drugs such as aspirin are often used with streptokinase, but may increase the risk of haemorrhage. The risk may also be increased with dextrans, and with other drugs that affect coagulation or platelet function.,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


►  Contraindication : peptic ulcer disease, cerebral bleeding, , pregnancy, hemorrhagic disorders , Stroke, Cerebral neoplasm,
Ref :-   Book : Martindale    Page : 1541   Edition : 38,
  ►  Mechanism of Action :   Streptokinase is a thrombolytic drug derived from various streptococci. It rapidly activates endogenous plasminogen, indirectly by means of a streptokinase-plasminogen complex, to plasmin which has fibrinolytic effects and can dissolve intravascular blood clots,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Terminalia belerica i.e. Bahera with Another pathway,

  ►  Pathway with its reference as follows :-
  • Fibrolytic activity --- (Ansari *, V. (2012). Antithrombotic and Thrombolytic activity of Terminalia belerica fruit extracts. Research Journal Of Pharmaceutical, Biological And Chemical Sciences, 3(2), 471. )

  •   ►  URL -- http://www.rjpbcs.com/pdf/2012_3%282%29/%5B55%5D.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   0.38 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1541   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,