Streptomycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 363   Edition : 37  

  ►   Brandname : Strepto-Fatol, Strepto-Hefa, Ambistryn-S, Cipstryn
  ►  Strength : Injection with 1 gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM
Reference :-   Book : Martindale    Page : 359   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis IM 15 mg/kg Injection Dose: given up to a maximum of 1 g daily. The maximum daily dose should be reduced to 500 to 750 mg in adults aged over 40 years, and in those weighing less than 50 kg.
2 Other infections IM 1 2 gm Injection Dose: given daily in divided doses, depending on tyhe suseptibility and severity of infection

Ref :-  Book : Martindale    Page : 363   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis 1 Month IM 20 40 mg/kg Injection
2 Brucellosis 1 Month IM 5 10 mg/kg Injection
3 Advanced meniere's disease IM 1 gm Injection b.d.

Ref :- Book : Martindale    Page : 363   Edition : 37  
Precaution :- If a Patient is using 'Streptomycin' drug in  acute kidney injury   disease, then Please be used with caution .

Precaution :- If a Patient is using 'Streptomycin' drug in  TUBERCULOSIS  disease, then Please Contraindication- May cause nephrotoxicity and neurotoxicity. .

Precaution :- If a Patient is using 'Streptomycin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : Neuromuscular-blocking action and respiratory depression and muscular paralysis, Polyradiculitis, and ventriculitis after intrathecal, intracisternal, or intraventricular . Subconjunctival injection of gentamicin may lead to pain, hyperaemia, and conjunctival oedema., Hypersensitivity reactions after local use, blood dyscrasias, purpura, nausea and vomiting, stomatitis, and signs of liver dysfunction such as increased serum-aminotransferase values and increased serum-bilirubin concentrations,, Encephalopathy, Confusion, Lethargy, Hallucinations, Convulsions, Mental depression, Atrophy or fat necrosis has been reported at injection sites, Arachnoiditis, Paresthesia, Peripheral neuropathy, Optic neuritis, Scotoma, Meningeal inflammation, Nerve root pain, Paraplegia, Neurotoxic complications, Hypersensitivity skin reactions, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Exfoliative dermatitis, Anaphylaxis, Aplastic anaemia, Granulocytosis
Ref :-   Book : Martindale    Page : 306, 362   Edition : 37.  

►  Drug Interaction : Drug interaction of Streptomycin is with AMINOGLYCOSIDES , Cephalosporin , General anaesthetics , Opioids, Bacteriostatic antibacterials, ,  Vancomycin , Cyclosporine , Cisplatin , Fludarabine, Etacrynic acid, Furosemide , Dimenhydrinate , Zalcitabine
Ref :-   Book : Martindale    Page : 307, 362   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by bacteriostatic antibacterials, but such combinations have been used successfully in practice. Renal excretion of zalcitabine may be reduced by aminoglycosides. Streptomycin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta.
Ref :-   Book : Martindale    Page : 307, 362   Edition : 37.  

►  Contraindication : Hypersensitivity, Renal impairment, Hepatic impairment, Pregnancy, It should be avoided in patients with myasthenia gravis, and great care is required in patients with parkinsonism and other conditions characterised by muscular weakness.
Ref :-   Book : Martindale    Page : 307, 362   Edition : 37.  
  ►  Mechanism of Action :   Streptomycin bind to specific 30S-subunit ribosomal proteins (S12 in the case of streptomycin). Protein synthesis is inhibited by the drug in at least three ways : (1) interference with the initiation complex of peptide formation; (2) misreading of mRNA, which causes incorporation of incorrect amino acids into the peptide and results in a nonfunctional or toxic protein; and (3) breakup of polysomes into nonfunctional monosomes. These activities occur more or less simultaneously, and the overall effect is irreversible and lethal for the cell.
Ref :-   Book : Basic & Clinical pharmacology    Page : 821,822   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 363   Edition : 37.  

►    Plasma Half-life :   Min value :-   2.5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 363   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   2 hours.  
Ref :-   Book : Martindale    Page : 363   Edition : 37.