Streptomycin is a Medicine belongs to DRUGS USED IN TUBERCULOSIS group whose information about Brand can be referenced from   Book : Martindale    Page : 360   Edition : 38,

  ►   Brandname : Ambistryn-S,Cipstryn

  ►  Strength : Injection with 1  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM,
Reference :-   Book : Martindale    Page : 359   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis IM 15 mg/kg Injection Daily.
2 Other infections IM 1 2 gm Injection Daily in divided doses.

Ref :-  Book : Martindale    Page : 359   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis 1 Month IM 20 40 mg/kg Injection
2 Brucellosis 1 Month <1 Month IM 5 10 mg/kg Injection q.i.d.
3 Other infections IM 40 mg/kg Injection

Ref :- Book : Martindale    Page : 359   Edition : 38,
Precaution :- If a Patient is using 'Streptomycin' drug in  acute kidney injury   disease, then Please be used with caution .

Precaution :- If a Patient is using 'Streptomycin' drug in  TUBERCULOSIS  disease, then Please Contraindication- May cause nephrotoxicity and neurotoxicity. .

Precaution :- If a Patient is using 'Streptomycin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : Vestibular Ototoxicity, hypersensitivity reactions, eosinophilia, peripheral neuropathies, optic neuritis, radiculitis, arachnoiditis, nerve root pain, paraplegia, Stevens-Johnson syndrome, epidermal necrolysis, anaphylaxis, anaemia, agranulocytosis, less nephrotoxic, Neuromuscular toxicity,
Ref :-   Book : Martindale    Page : 306, 359   Edition : 38,

►  Drug Interaction : Drug interaction of Streptomycin is with aminoglycoside, Vancomycin , Amiloride , Cyclosporine , Cisplatin , Fludarabine, Etacrynic acid, Furosemide , Dimenhydrinate , Atracurium , Testosterone , Flecainide Acetate , Zalcitabine,
Ref :-   Book : Martindale    Page : 304, 309, 307, 359, 2032   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs (including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine), or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of streptomycin toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. Care is also required if other drugs like Atracurium with a neuromuscular-blocking action are used. The neuromuscular-blocking properties of streptomycin may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. The streptomycin is inactivated in vitro by various penicillins and cephalosporins via an interaction with the beta-lactam ring, the extent of inactivation depending on temperature, concentration, and duration of contact. Streptomycin exhibits synergy with beta lactams, probably because the effects of the latter on bacterial cell walls enhance its penetration. Renal excretion of zalcitabine may be reduced by streptomycin. Streptomycin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta. ,
Ref :-   Book : Martindale    Page : 304,309,359   Edition : 38,


►  Contraindication : Hypersensitivity, myasthenia gravis, muscle weakness, Parkinson’s disease, hepatic impairment, renal impairment, Fever, pregnancy, ,
Ref :-   Book : Martindale    Page : 306,359   Edition : 38,
  ►  Mechanism of Action :   Streptomycin bind to specific 30S-subunit ribosomal proteins (S12 in the case of streptomycin). Protein synthesis is inhibited by the drug in at least three ways : (1) interference with the initiation complex of peptide formation; (2) misreading of mRNA, which causes incorporation of incorrect amino acids into the peptide and results in a nonfunctional or toxic protein; and (3) breakup of polysomes into nonfunctional monosomes. These activities occur more or less simultaneously, and the overall effect is irreversible and lethal for the cell.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 821,822   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 363   Edition : 37,


►    Plasma Half-life :
  Min value :-   2.5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1541   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,