Sulfadiazine is a Medicine belongs to Sulfonamide group whose information about Brand can be referenced from   Book : Martindale    Page : 366   Edition : 37,

  ►   Brandname : Aubril,Zad-G

  ►  Strength : Tablet with 500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 365   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible infections Oral 2 4 gm Tablet Daily in divided doses.
2 Toxoplasmosis Oral 4 6 gm Tablet Daily in 4 divided doses for at least 6 weeks.
3 Prophylaxis of rheumatic fever Oral 500 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 365   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Congenital toxoplasmosis > 1 Day > 28 Day Oral 50 mg/kg Tablet b.d.
2 Acquired toxoplasmosis Oral 25 50 mg/kg Tablet q.i.d.
3 Chronic suppression of toxoplasmosis Oral 85 120 mg/kg Tablet
4 Rheumatic fever Oral 500 mg Tablet o.d.

Ref :- Book : Martindale    Page : 365,366   Edition : 37,
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Sulfadiazine is with Magnesium/Magnesium Sulphate, Procainamide , Ropinirole , Methotrexate, Phenytoin , Ropivacaine , ,
Ref :-   Book : Martindale    Page : 370   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The action of Sulfadiazine may be antagonised by paminobenzoic acid and its derivatives, particularly potassium aminobenzoate and the procaine group of local anaesthetics. Sulfadiazine may potentiate the effects of some drugs, such as oral anticoagulants, methotrexate, and phenytoin; this may be due to displacement of the drug from plasma protein binding sites or to inhibition of metabolism. However, the clinical significance of these interactions appears to depend on the particular involved. The possibility of interactions with other highly protein-bound drugs, such as NSAIDs, should be considered.,
Ref :-   Book : Martindale    Page : 370   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment, blood disorders, Hypersensitivity, lupus erythematosus,
Ref :-   Book : Martindale    Page : 369   Edition : 37,
  ►  Mechanism of Action :   PABA analogues that competitively inhibit microbial dihydropterotes synthase and thereby prevent the synthesis of folic acid.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 579   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- VITAMIN B12 with Decrease in Nutrient Level,

  ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://ajpcr.com/Vol2Issue4/226.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KELP with Taking high dose could provide too much iodine and interfere with the action of this medicine, turmeric reduce drug induce toxicity and may also reduce effectiveness of drug,

      ►  Reference :-
  • PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007.

  •   ►  URL -- http://www.abebooks.com/PDR-Herbal-Medicines-4th-Edition-Thomson/14662393711/bd,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 365   Edition : 37,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 365   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 365   Edition : 37,