Sulfadiazine is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 366   Edition : 37  

  ►   Brandname : Aubril, Zad-G
  ►  Strength : Tablet with 500 mg.  Injection with .  Oral Suspension with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12   Martindale    Page : 366   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM
Reference :-   Book : Martindale    Page : 365   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible infections Oral 2 4 gm Tablet Daily in divided doses.
2 Toxoplasmosis Oral 4 6 gm Tablet Daily in 4 divided doses for at least 6 weeks, ollowed by a suppressive dose of 2 to 4 g daily, which should continue indefinitely.
3 Prophylaxis of rheumatic fever Oral 500 mg Tablet o.d. For patients weighing less than about 30 kg are given 500 mg once daily, while those over 30 kg may receive 1 g once daily

Ref :-  Book : Martindale    Page : 365   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Congenital toxoplasmosis Oral 50 mg/kg Tablet b.d.
2 Acquired toxoplasmosis Oral 25 50 mg/kg Tablet
3 Chronic suppression of toxoplasmosis Oral 85 120 mg/kg Tablet
4 Recurrent rheumatic fever

Ref :- Book : Martindale    Page : 366   Edition : 37  
►  Side Effect : Nausea, Vomiting, Anorexia, Diarrhoea, Hypersensitivity reactions, Rashes, pruritus, Photosensitivity reactions, Exfoliative dermatitis, Erythema nodosum, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Dermatitis, Interstitial nephritis, Tubular necrosis, Lumbar pain, Haematuria, Oliguria, Anuria, Agranulocytosis, Aplastic anaemia, Thrombocytopenia, leucopenia, Hypoprothrombinaemia, Eosinophilia, Syndrome resembling serum sickness, Hepatic necrosis, Hepatomegaly, Jaundice, Myocarditis, Pulmonary eosinophilia, Fibrosing alveolitis, Vasculitis, Polyarteritis nodosa, Hypoglycaemia, Hypothyroidism, Neurological reactions, Aseptic meningitis, Ataxia, Benign intracranial hypertension, Convulsions, Dizziness, Drowsiness, Fatigue, Headache, Insomnia, Mental depression, Peripheral or optic neuropathies, Psychoses, Tinnitus, Vertigo, Pancreatitis, Pseudomembranous colitis
Ref :-   Book : Martindale    Page : 365, 369   Edition : 37.  

►  Drug Interaction : Drug interaction of Sulfadiazine is with , , Oral anticoagulants, NSAIDS,  Procaine, Methotrexate, Phenytoin
Ref :-   Book : Martindale    Page : 365, 370   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  The action of sulfonamides may be antagonised by paminobenzoic acid and its derivatives, particularly potassium aminobenzoate and the procaine group of local anaesthetics. Sulfamethoxazole and other sulfonamides may potentiate the effects of some drugs, such as oral anticoagulants , methotrexate, and phenytoin; this may be due to displacement of the drug from plasma protein binding sites or to inhibition of metabolism. However, the clinical significance of these interactions appears to depend on the particular sulfonamide involved. The possibility of interactions with other highly protein-bound drugs, such as NSAIDs, should be considered. High doses of sulfonamides have been reported to have a hypoglycaemic effect; the antidiabetic effect of the sulfonylurea compounds may be enhanced by sulfonamides.
Ref :-   Book : Martindale    Page : 365,370   Edition : 37.  


►  Contraindication : Hepatic impairment, Renal impairment, Blood disorders, Treatment with sulfonamides should be stopped immediately a rash appears because of the danger of severe allergic reactions such as the Stevens-Johnson syndrome., Sulfadiazine should not be given to patients with a history of hypersensitivity to sulfonamides as cross-sensitivity may occur between drugs of this group. Care is generally advisable in patients with a history of allergy or asthma, Caution is also needed in the elderly, who may be more likely to have other risk factors for reactions. Some consider sulfamethoxazole to be contra-indicated in lupus erythematosus as it may exacerbate the condition. , Sulfadiazine and other sulfonamides are not usually given to infants within 1 to 2 months of birth because of the risk of producing kernicterus; for the same reason, they are generally contra-indicated in women prior to delivery, Sulfonamides have been reported to interfere with some diagnostic tests, including those for urea, creatinine, and urinary glucose and urobilinogen.
Ref :-   Book : Martindale    Page : 365, 369   Edition : 37.  
  ►  Mechanism of Action :   PABA analogues that competitively inhibit microbial dihydropterotes synthase and thereby prevent the synthesis of folic acid.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 579   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- KELP with Taking high dose could provide too much iodine and interfere with the action of this medicine, turmeric reduce drug induce toxicity and may also reduce effectiveness of drug.  

  ►  Reference :-
  • PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007.

  •   ►  URL -- http://www.abebooks.com/PDR-Herbal-Medicines-4th-Edition-Thomson/14662393711/bd

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 365   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 365   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   6 hours.  
    Ref :-   Book : Martindale    Page : 365   Edition : 37.