Sulfadoxine and Pyrimethamine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 917   Edition : 12,    Page :   Edition : ,

  ►   Brandname : Fansidar,Larinate kit

  ►  Strength : Tablet with 25+500  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 837   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 925   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute attack of malaria Oral Tablet A single dose Sulfadoxine: 1.5 g Pyrimethamine: 75 mg .

Ref :-  Book : Clinical Pharmacology    Page : 274   Edition : 9,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Uncomplicated falciparum malaria 2 Month <2 Month Oral 12.5 mg Tablet

Ref :- Book : Martindale    Page : 665   Edition : 37,
►  Side Effect : erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis,
Ref :-   Book : Clinical Pharmacology    Page : 274   Edition : 9,

►  Drug Interaction : Drug interaction of Sulfadoxine and Pyrimethamine is with cotrimoxazole, Trimethoprim , Methotrexate, Phenytoin , Zidovudine,
Ref :-   Book : Martindale    Page : 665   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Absolute Contraindication : Infants within 1 to 2 months of birth   pregnant women at term   hypersensitivity (to both or to the sulfonamides or trimethoprim)   severe hepatic or renal impairment   megaloblstic anemia due to folate deficiency.  

►  Contraindication : pregnancy,
Ref :-   Book : Clinical Pharmacology    Page : 274   Edition : 9,
  ►  Mechanism of Action :   Pyrimethamine acts synergistically with sulfadoxine to inhibit folic acid metabolism. ,
Ref :-   Book : Clinical Pharmacology    Page : 274   Edition : 9,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Basic & Clinical pharmacology    Page : 925   Edition : 12,


►    Plasma Half-life :
  Min value :-   170 hours,    Max value :-   NA
Ref :-   Book : Basic & Clinical pharmacology    Page : 925   Edition : 12,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   8 hours,
Ref :-   Book : Basic & Clinical pharmacology    Page : 925   Edition : 12,