Sulfamethoxazole is a Medicine belongs to Sulfonamide group whose information about Brand can be referenced from   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19,

  ►   Brandname : Gantanol

  ►  Strength : Tablet with 500  mg, Suspension with 500/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 370   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated urinary-track infection Oral 2 gm Tablet
2 Severe infections Oral 1 gm Tablet t.i.d.

Ref :-  Book : Martindale    Page : 365   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 infection Oral 50 60 mg/kg Tablet

Ref :- Book : Martindale    Page : 365   Edition : 38,
►  Side Effect : fever, Skin rashes, exfoliative dermatitis, photosensitivity, Urticaria, nausea, vomiting, diarrhea, Stevens-Johnson syndrome, Crystalluria, stomatitis, conjunctivitis, arthritis, haemolytic anaemia, aplastic anaemia, granulocytopenia, thrombocytopenia, leukemoid reactions, hepatitis, polyarteritis nodosa, Psychosis, Kernicterus in newborns,
Ref :-   Book : Basic & Clinical pharmacology    Page : 833   Edition : 12,

►  Drug Interaction : Drug interaction of Sulfamethoxazole is with Ropinirole , Methotrexate, Phenytoin , Ropivacaine , Amlodipine , , Phenytoin , Digoxin , Procainamide , Rosiglitazone , Repaglinide , Zidovudine, Zalcitabine, Lamivudine, Dapsone , Rifampicin , Cyclosporine , Tenecteplase , Sertraline,
Ref :-   Book : Martindale    Page : 386   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Protein displacement with warfarin, phenytoin, methotrexate.,
Ref :-   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19,


►  Contraindication : hepatic impairment, renal impairment, Allergy, asthma, rash, leucopenia,
Ref :-   Book : Martindale    Page : 365   Edition : 38,
  ►  Mechanism of Action :   Sulfonamide-susceptible organisms, unlike mammals, cannot use exogenous folate but must synthesize it from PABA. This pathway is thus essential for production of purines and nucleic acid synthesis. As structural analogs of PABA, sulfonamides inhibit dihydropteroate synthase and folate production.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 831   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Angelica (seed); Baphicacanthus (leaves) with Another pathway,

  ►  Pathway with its reference as follows :-
  • ferulic acid have antibacterial effect --- (: Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B12 with Decrease in Nutrient Level,

      ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://ajpcr.com/Vol2Issue4/226.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 370   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   12 hours,
    Ref :-   Book : Martindale    Page : 370   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 370   Edition : 38,