Sulfamethoxazole is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19   Martindale    Page : 370   Edition : 37  

  ►   Brandname : Gantanol, Berlocid, Cotrim, Cotrim-Diolan, Bactrim, Resprim, Ciplin, Colizole
  ►  Strength : Tablet with 500 mg.  Suspension with 500 mg/5mL.  with

Reference of this Medicine for its Strength can be taken from   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19   Martindale    Page : 370   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 370   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial Oral 2 gm Dose followed by 1 g twice daily. In severe infections 1 g three times daily has been given.

Ref :-  Book : Martindale    Page : 370   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antibacterial Oral 50 60 mg/kg

Ref :- Book : Martindale    Page : 370   Edition : 37  
►  Side Effect : Nausea, Vomiting, Anorexia, Diarrhoea, Hypersensitivity reactions, Rashes, pruritus, Photosensitivity reactions, Exfoliative dermatitis, Erythema nodosum, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Dermatitis, Interstitial nephritis, Tubular necrosis, Lumbar pain, Haematuria, Oliguria, Anuria, Agranulocytosis, Aplastic anaemia, Thrombocytopenia, leucopenia, Hypoprothrombinaemia, Eosinophilia, Syndrome resembling serum sickness, Hepatic necrosis, Hepatomegaly, Jaundice, Myocarditis, Pulmonary eosinophilia, Fibrosing alveolitis, Vasculitis, Polyarteritis nodosa, Hypoglycaemia, Hypothyroidism, Neurological reactions, Aseptic meningitis, Ataxia, Benign intracranial hypertension, Convulsions, Dizziness, Drowsiness, Fatigue, Headache, Insomnia, Mental depression, Peripheral or optic neuropathies, Psychoses, Tinnitus, Vertigo, Pancreatitis, Pseudomembranous colitis
Ref :-   Book : Martindale    Page : 369   Edition : 37.  

►  Drug Interaction : Drug interaction of Sulfamethoxazole is with , , Oral anticoagulants, NSAIDS,  Procaine, Methotrexate, Phenytoin
Ref :-   Book : Martindale    Page : 370   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The action of sulfonamides may be antagonised by paminobenzoic acid and its derivatives, particularly potassium aminobenzoate and the procaine group of local anaesthetics. Sulfamethoxazole and other sulfonamides may potentiate the effects of some drugs, such as oral anticoagulants , methotrexate, and phenytoin; this may be due to displacement of the drug from plasma protein binding sites or to inhibition of metabolism. However, the clinical significance of these interactions appears to depend on the particular sulfonamide involved. The possibility of interactions with other highly protein-bound drugs, such as NSAIDs, should be considered. High doses of sulfonamides have been reported to have a hypoglycaemic effect; the antidiabetic effect of the sulfonylurea compounds may be enhanced by sulfonamides.
Ref :-   Book : Martindale    Page : 370   Edition : 37.  

►  Contraindication : Hepatic impairment, Renal impairment, Blood disorders, Treatment with sulfonamides should be stopped immediately a rash appears because of the danger of severe allergic reactions such as the Stevens-Johnson syndrome., Sulfamethoxazole should not be given to patients with a history of hypersensitivity to sulfonamides as cross-sensitivity may occur between drugs of this group. Care is generally advisable in patients with a history of allergy or asthma, Caution is also needed in the elderly, who may be more likely to have other risk factors for reactions. Some consider sulfamethoxazole to be contra-indicated in lupus erythematosus as it may exacerbate the condition. , Sulfamethoxazole and other sulfonamides are not usually given to infants within 1 to 2 months of birth because of the risk of producing kernicterus; for the same reason, they are generally contra-indicated in women prior to delivery, Patients with AIDS may be particularly prone to adverse reactions, especially when sulfamethoxazole is given with trimethoprim as co-trimoxazole, Sulfonamides have been reported to interfere with some diagnostic tests, including those for urea, creatinine, and urinary glucose and urobilinogen.
Ref :-   Book : Martindale    Page : 369   Edition : 37.  
  ►  Mechanism of Action :   Sulfonamide-susceptible organisms, unlike mammals, cannot use exogenous folate but must synthesize it from PABA. This pathway is thus essential for production of purines and nucleic acid synthesis. As structural analogs of PABA, sulfonamides inhibit dihydropteroate synthase and folate production.
Ref :-   Book : Basic & Clinical pharmacology    Page : 831   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Angelica (seed); Baphicacanthus (leaves) with Another pathway.  

  ►  Pathway with its reference as follows :-
  • ferulic acid have antibacterial effect --- (: Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL --
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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- VITAMIN B12 with Decrease in Nutrient Level.  

      ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL --

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism)
    Ref :-   Book : Martindale    Page : 370   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   12 hours.  
    Ref :-   Book : Martindale    Page : 370   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 370   Edition : 37.