Sulfasalazine is a Medicine belongs to Antirheumatoid group whose information about Brand can be referenced from   Book : Martindale    Page : 1931   Edition : 37,

  ►   Brandname : Saaz,Salazar,Sazo,Salazopyrin,Sulazine,Azulfidine

  ►  Strength : Tablet with 500  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : rectal, Oral,
Reference :-   Book : Martindale    Page : 1930   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Inflammatory bowel disease Oral 1 2 gm Tablet q.i.d.
2 Rheumatoid arthiritis Oral 500 mg Tablet Daily.

Ref :-  Book : Martindale    Page : 1890   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Inflammatory bowel disease 2 Year <2 Year Oral 40 60 mg/kg Tablet
2 Ulcerative colitis 2 Year <2 Year Oral 20 30 mg/kg Tablet
3 juvenile rheumatoid arthritis 2 Year 18 Year Oral 5 mg/kg Tablet b.d.

Ref :- Book : Martindale    Page : 1930   Edition : 37,
Precaution :- If a Patient is using 'Sulfasalazine' drug in  thallasemia  disease, then Please Avoid .

►  Side Effect : headache, nausea, fatigue, allergic reaction, Rashes, fever, Stevens-Johnson syndrome, hepatitis, pneumonitis, haemolytic anaemia, Bone marrow suppression, hypersenstivity,
Ref :-   Book : Martindale    Page : 1928   Edition : 37,

►  Drug Interaction : Drug interaction of Sulfasalazine is with Mercaptopurine, Digoxin , Doxylamine Succinate , Rifampicin , Ethambutol , Ampicillin ,
Ref :-   Book : Martindale    Page : 817,1930   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Since the effects of sulfasalazine depend on release of 5-aminosalicylic acid by bacterial metabolism in the gut, any drug that reduces the intestinal microflora may reduce the production of active metabolite. For mention of 5-aminosalicylates such as sulfasalazine inhibiting the metabolism of thiopurine antineoplastics, and increasing their toxicity. ,
Ref :-   Book : Martindale    Page : 1930   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 1929   Edition : 37,
  ►  Mechanism of Action :   Sulfasalazine is a compound of a sulfonamide, sulfapyridine, with 5-aminosalicylic acid (mesalazine). Its activity is generally considered to lie in the 5-aminosalicylic acid moiety, which is released in the colon by bacterial metabolism, although intact sulfasalazine has some anti-inflammatory properties in its own right,
Ref :-   Book : Martindale    Page : 1930   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- fish oil with Another pathway, fish oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-inflamatory --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antiinflammatory effect --- (PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007. )
  • anti-inflamatory --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antiinflammatory effect --- (PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, http://www.abebooks.com/PDR-Herbal-Medicines-4th-Edition-Thomson/14662393711/bd,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B12 with Decrease in Nutrient Level,

      ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://ajpcr.com/Vol2Issue4/226.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 646   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   17 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 646   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,