Sulfinpyrazone is a Medicine belongs to Anti gout group whose information about Brand can be referenced from   Book : Martindale    Page : 609   Edition : 37  

  ►   Brandname : Anturan, Anturane.
  ►  Strength : Tablet with 100 mg.  Capsule with 200 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 609   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antigout The initial oral dose of sulfinpyrazone in the UK is 100 to 200 mg daily (the USA allows up to 200 mg twice daily), taken with meals or milk. This may be gradually increased over 1 to 3 weeks until a daily dosage of 600 mg is reached; up to 800 mg daily may be given if necessary. After the plasma-urate concentration has been controlled, the daily maintenance dose may be reduced to as low as 200 mg. An adequate fluid intake is required to prevent formation of uric acid renal calculi

Ref :-  Book : Martindale    Page : 609   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Nausea, Vomiting, Diarrhoea, Abdominal pain, Gastric bleeding or aggravate existing peptic ulcers, Skin rashes, Hypersensitivity reactions, Aplastic anaemia, Agranulocytosis, Leukopenia, Thrombocytopenia
Ref :-   Book : Martindale    Page : 608   Edition : 37.  

►  Drug Interaction : Drug interaction of Sulfinpyrazone is with Diuretics, PENICILLINS , Anticoagulant ,  Pyrazinamide , Aspirin, Probenecid , Warfarin , Acenocoumarol, Phenytoin , Theophylline
Ref :-   Book : Martindale    Page : 609   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Doses of sulfinpyrazone may need to be increased if it is given with other drugs, such as diuretics or pyrazinamide, that increase uric acid concentrations. Sulfinpyrazone and salicylates including aspirin are mutually antagonistic and should not be used together. There may also be an increased risk of bleeding when sulfinpyrazone is used with other drugs such as aspirin that inhibit platelet function. Sulfinpyrazone’s renal tubular secretion is inhibited by probenecid although with little clinical effect. Since sulfinpyrazone, like probenecid, inhibits the tubular secretion of weak organic acids, interactions can be expected with penicillins although the effect is not considered to be clinically useful. Sulfinpyrazone can potentiate the action of some drugs. The most significant interaction of this type involves warfarin, acenocoumarol, and possibly other coumarin anticoagulants. Patients receiving sulfinpyrazone and such an anticoagulant should have their prothrombin times monitored and the anticoagulant dosage reduced as appropriate. Similarly, sulfinpyrazone may potentiate the effects of phenytoin (see Antigout Drugs, and possibly some sulfonamides and sulfonylureas. In contrast, sulfinpyrazone may increase the metabolism of theophylline and diminish its activity
Ref :-   Book : Martindale    Page : 609   Edition : 37.  

►  Contraindication : Renal impairment, Hepatic impairment, Blood dyscrasias or blood coagulation disorders, and in patients with uric acid renal calculi or peptic ulcer disease or a history of such disorders, Sulfinpyrazone should not be started during an acute attack of gout; however, treatment is usually continued when acute attacks occur in patients already receiving the drug, and the acute attack is treated separately. Sulfinpyrazone is not suitable for the control of hyperuricaemia associated with cancer or cancer chemotherapy., Sulfinpyrazone should not be given to patients hypersensitive to it or to other pyrazole derivatives such as phenylbutazone; nor should it be given to patients in whom hypersensitivity reactions (including bronchospastic reactions in asthmatics) have been provoked by aspirin or by other drugs with prostaglandin-synthetase inhibiting activity
Ref :-   Book : Martindale    Page : 608, 609   Edition : 37.  
  ►  Mechanism of Action :   Sulfinpyrazone is used in chronic gout to inhibit the renal tubular reabsorption of uric acid so increasing the urinary excretion of uric acid, lowering plasma-urate concentrations, and eventually reducing urate deposits in the tissues. It is therefore of value in hyperuricaemia caused by decreased uric acid excretion rather than increased urate production and is not used for hyperuricaemia associated with cancer or cancer therapy
Ref :-   Book : Martindale    Page : 609   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 609   Edition : 37.  

►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours.  
Ref :-   Book :    Page :    Edition : .  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA