Sumatriptan is a Medicine belongs to antimigraine drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 682   Edition : 37  

  ►   Brandname : migran, Sumagran, Suminat
  ►  Strength : Tablet with 25 Mg.  Tablet with 50 Mg.  Tablet with 100 Mg.  Nasal Spray with 5 Mg.  Nasal Spray with 20 Mg.  Injection with 4 mg/ml.  Injection with 6 mg/ml.  Oral Suspension with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12      Page :    Edition :    Martindale    Page : 682   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, Oral, intranasal
Reference :-   Book : Martindale    Page : 681   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Migraine Oral 50 mg Tablet Although some patients may require 100 mg. A clinical response can be expected after about 30 minutes. If symptoms recur after an initial response, further doses may be given provided that there is a minimum interval of 2 hours between doses and that not more than 300 mg is taken in any 24-hour period.
2 Migraine intranasal 20 mg Nasal Spray Given a single dose Into one nostril, although 10 mg may be effective in some patients
3 Migraine SC 6 mg Injection Given in a single dose. A clinical response may be expected after 10 to 15 minutes. If symptoms recur, a second dose of 6 mg may be injected at least one hour after the first dose; not more than 12 mg should be given in a 24-hour period.
4 Cluster headache Sumatriptan succinate is given by subcutaneous injection in similar doses to those used for migraine.

Ref :-  Book : Martindale    Page : 681   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Migraine 6Year 10Year Oral 25 mg Tablet
2 Migraine 10 Year 12 Year Oral 50 mg Tablet
3 Migraine 12Year 18Year Oral 50 100 mg Tablet
4 Migraine SC 6 mg Injection
5 Migraine 12 Year 17 Year intranasal 10 mg Nasal Spray o.d.
6 Cluster headache

Ref :- Book : Martindale    Page : 681   Edition : 37  
►  Side Effect : Dizziness, Flushing, Weakness, Drowsiness, Fatigue, Nausea, Vomiting, Dyspnoea, Sensory disturbances, Paraesthesia, Hypoaesthesia, Pain or sensations of heaviness, heat or cold, pressure, or tightness have also been commonly reported, can affect any part of the body including the throat and chest, and may be intense, Cardiac arrhythmias, Myocardial ischaemia, Myocardial infarction, Transient increases in blood pressure, Hypotension, Bradycardia, Tachycardia, palpitations, Raynaud’s syndrome, Ischaemic colitis, Visual disturbances
Ref :-   Book : Martindale    Page : 679   Edition : 37.  

►  Drug Interaction : Drug interaction of Sumatriptan is with , Monoamine Oxidase Inhibitor,  Methysergide
Ref :-   Book : Martindale    Page : 681   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Sumatriptan and other serotonin (5-HT1) agonists should not be given with ergotamine or related compounds (including methysergide) since there is an increased risk of vasospastic reactions. In addition, a delay is advised before starting a serotonin (5-HT1) agonist in patients who have been receiving ergotamine or related compounds: sumatriptan, almotriptan, eletriptan, frovatriptan, rizatriptan, or zolmitriptan should not be given until at least 24 hours after stopping the use of ergotamine preparations. Conversely, ergotamine should not be given until 6 hours after stopping these drugs or at least 24 hours in the case of eletriptan and frovatriptan, and naratriptan. Serotonin (5- HT1) agonists should not be given together. Sumatriptan or rizatriptan should not be used with, and for 2 weeks after stopping, an MAOI. Use with the selective monoamine oxidase type B inhibitor selegiline is thought unlikely to provoke an interaction.
Ref :-   Book : Martindale    Page : 681   Edition : 37.  


►  Contraindication : Uncontrolled hypertension, Ischaemic heart disease (coronary artery disease), History of myocardial infarction, Coronary vasospasm (Prinzmetal’s angina), Peripheral vascular disease, Previous cerebrovascular accident, Transient ischaemic attack, Hepatic impairment, Renal impairment, Sumatriptan and other serotonin (5-HT1) agonists should only be used where there is a clear diagnosis of migraine or cluster headache and care should be taken to exclude other potentially serious neurological conditions. They should not be used for prophylaxis and should not be given to patients with basilar, hemiplegic, or ophthalmoplegic migraine., Sumatriptan should not be used intravenously because of the increased risk of producing coronary vasospasm
Ref :-   Book : Martindale    Page : 680   Edition : 37.  
  ►  Mechanism of Action :   Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors and produces vasoconstriction of cranial arteries. Drugs like sumatriptan, which are commonly known as triptans, are believed to act mainly at 5-HT1B and 5-HT1D subtype receptors and are therefore sometimes referred to as 5HT1B/1D-receptor agonists
Ref :-   Book : Martindale    Page : 681   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug.  

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 681   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 681   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 681   Edition : 37.