Sumatriptan is a Medicine belongs to 5- HT Agonists group whose information about Brand can be referenced from   Book : Martindale    Page : 682   Edition : 37,

  ►   Brandname : Imigran,suminat,sumavel

  ►  Strength : Tablet with 25  Mg, Tablet with 50  Mg, Tablet with 100  Mg, Nasal Drop with 5  Mg, Nasal Drop with 20  Mg, Injection with 4  mg/ml, Injection with 6  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, Oral, intranasal,
Reference :-   Book : Martindale    Page : 681   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Migraine Oral 50 mg Tablet
2 Migraine intranasal 20 mg Nasal Spray Given a single dose Into one nostril.
3 Migraine SC 6 mg Injection In a single dose.
4 Cluster headache SC 6 mg Injection In a single dose.

Ref :-  Book : Martindale    Page : 681   Edition : 37, Martindale    Page : 679   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Migraine 12 Year 17 Year intranasal 10 mg Nasal Spray
2 Migraine 6 Year 10 Year Oral 25 mg Tablet
3 Migraine 10 Year 12 Year Oral 50 mg Tablet
4 Migraine 12 Year 18 Year Oral 50 100 mg Tablet

Ref :- Book : Martindale    Page : 681   Edition : 37,
►  Side Effect : Dizziness, flushing, weakness, drowsiness, fatigue, nausea, vomiting, dyspnoea, sensory disturbances, paraesthesia, hypoaesthesia, hypotension, bradycardia, tachycardia, palpitations, Raynaud’s syndrome, ischemic colitis, cardiac arrhythmia, myocardial ischaemia, myocardial infraction, hypersensitivity reactions, anaphylaxis,
Ref :-   Book : Martindale    Page : 679   Edition : 37,

►  Drug Interaction : Drug interaction of Sumatriptan is with Sumatriptan ,
Ref :-   Book : Martindale    Page : 680   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Sumatriptan and other serotonin (5-HT1) agonists should not be given with ergotamine or related compounds (including methysergide) since there is an increased risk of vasospastic reactions. Sumatriptan or rizatriptan should not be used with, and for 2 weeks after stopping, an MAOI. Use with the selective monoamine oxidase type B inhibitor selegiline is thought unlikely to provoke an interaction. ,
Ref :-   Book : Martindale    Page : 680,681   Edition : 37,


►  Contraindication : Basilar, hemiplegic, or ophthalmoplegic migraine, prophylaxis , ophthalmoplegic migraine,
Ref :-   Book : Martindale    Page : 680   Edition : 37,
  ►  Mechanism of Action :   Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors and produces vasoconstriction of cranial arteries. Drugs like sumatriptan, which are commonly known as triptans, are believed to act mainly at 5-HT1B and 5-HT1D subtype receptors and are therefore sometimes referred to as 5HT1B/1D-receptor agonists,
Ref :-   Book : Martindale    Page : 681   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • seed of kankushta contain 5-hydroxytryptophan which is precursor of serotonin --- (Mehta, H. (2015). A REVIEW ON GRIFFONIA SIMPLICIFOLLIA – A NATURAL ANTI-DEPRESSANT. International Journal Of Phytopharmacology, 6(2), 76-79. )

  •   ►  URL -- www.onlineijp.com/download.php?f=1427544936(onlineijp).pdf&id...,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 681   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 681   Edition : 37,