Sunitinib is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 851   Edition : 37,

  ►   Brandname : Sutent REF-2

  ►  Strength : Capsule with 12.5  mg, Capsule with 25  mg, Capsule with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 851   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 851   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gastrointestinal stromal tumours Oral 50 mg Capsule o.d.

Ref :-  Book : Martindale    Page : 859   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bleeding, hypertension, proteinuria, arterial thromboembolic events, intestinal perforation,
Ref :-   Book : Martindale    Page : 851   Edition : 37,

►  Drug Interaction : Drug interaction of Sunitinib is with Dexamethasone , Phenytoin , Carbamazapine , Phenobarbital , Glucagon , Hydroxycarbamide (Hydroxyurea), Pioglitazone Hydrochloride ,
Ref :-   Book : Martindale    Page : 851   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  P450 isoenzyme CYP3A4 to produce an active metabolite, which is further metabolised by CYP3A4. Ketoconazole increased exposure to sunitinib, and use with other potent inhibitors of CYP3A4 (such as other azole antifungals, macrolide antibacterials, HIV-protease inhibitors, or grapefruit juice) may also increase sunitinib concentrations. Conversely, use with rifampicin decreased exposure to sunitinib, and inducers of CYP3A4 (such as dexamethasone, phenytoin, carbamazepine, phenobarbital, or St John’s wort) may decrease plasma sunitinib concentrations ,
Ref :-   Book : Martindale    Page : 851   Edition : 37,


►  Contraindication : ,
Ref :-   Book :    Page :    Edition : ,
  ►  Mechanism of Action :   Sunitinib malate is an inhibitor of several receptor tyrosine kinases.,
Ref :-   Book : Martindale    Page : 851   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 851   Edition : 37,


►    Plasma Half-life :
  Min value :-   80 hours,    Max value :-   110 hours,
Ref :-   Book : Martindale    Page : 851   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   6 hours,    Max value :-   12 hours,
Ref :-   Book : Martindale    Page : 851   Edition : 37,