Suramin sodium is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Martindale    Page : 936   Edition : 37  

  ►   Brandname : Germanin
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 936   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : slow i.v
Reference :-   Book : Martindale    Page : 936   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Early-stage trypanosomiasis Slow IV 5 mg/kg Injection A (test) dose of 5 mg/kg of suramin on day 1, 10 mg/kg on day 3, then 20 mg/kg on days 5, 11, 17, 23, and 30. Another schedule consist of a test dose of 100 to 200 mg and then 5 doses of 1 g given on days 1, 3, 7, 14 and 21

Ref :-  Book : Martindale    Page : 936   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Early-stage African trypanosomiasis Slow IV 5 mg/kg Injection

Ref :- Book : Martindale    Page : 936   Edition : 37  
►  Side Effect : Nausea, Vomiting, Shock, Seizures, Loss of consciousness, Abdominal pain, Mouth ulceration, Urticaria, pruritus, Paraesthesia, Paraesthesia, hyperaesthesia of the palms and soles, Skin eruptions, Blood dyscrasias, Fever, Polyuria, Increased thirst, Raised liver enzyme values, Fatigue, Photophobia, Lachrymation, Proteinuria, Haematuria, Casts in the urine
Ref :-   Book : Martindale    Page : 935   Edition : 37.  

►  Drug Interaction : Drug interaction of Suramin sodium is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Suramin sodium should be used under close supervision, and the general condition of patients improved as far as possible before treatment starts. Patients who have a severe reaction to the first dose should never receive suramin again., It should not be used in elderly or infirm patients or in the presence of severe hepatic or renal disease. The urine should be tested before treatment starts and weekly during treatment; dosage should be reduced if moderate proteinuria develops and stopped if it becomes severe or if casts appear in the urine.
Ref :-   Book : Martindale    Page : 935   Edition : 37.  
  ►  Mechanism of Action :   Suramin interacts with many macromolecules and inhibits numerous enzymes, including those involved in energy metabolism ( eg, glycerol phosphate dehydrogenase). It also inhibits RNA polymerase and thus interferes with parasite replication.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 646   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal
Ref :-   Book : Basic & Clinical pharmacology    Page : 933   Edition : 12.  

►    Plasma Half-life :   Min value :-   50 days,    Max value :-   NA
Ref :-   Book : Basic & Clinical pharmacology    Page : 933   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   several weeks,    Max value :-   NA
Ref :-   Book : Martindale    Page : 935   Edition : 37.