Tacrine is a Medicine belongs to CHOLINESTERASE INHIBITORS group whose information about Brand can be referenced from   Book : Martindale    Page : 401   Edition : 37  

  ►   Brandname : Cognex
  ►  Strength : Tablet with 10 mg.  Tablet with 20 mg.  Tablet with 30 mg.  Tablet with 40 mg.  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12   Martindale    Page : 401   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV
Reference :-   Book : Martindale    Page : 401   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderately severe dementia in Alzheimer’s disease Oral 10 mg Tablet Dose: Given four times a day for a minimum of 4 weeks. Dosage should not be increased during this period because the potential exists for a delay in onset of increased liver enzyme concentrations.

Ref :-  Book : Martindale    Page : 401   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Nausea, Vomiting, Anorexia, Diarrhea, Fatigue, Dizziness, Abdominal pain, Dyspepsia, Rashes, pruritus, Headache, Somnolence, Muscle cramp, Insomnia, Sweating, Tremor, Syncope, Upper respiratory-tract infections, Urinary-tract infections, Psychiatric disturbances, Depression, Hallucinations, Agitation, Aggressive behaviour, Confusion
Ref :-   Book : Martindale    Page : 394,400   Edition : 37.  

►  Drug Interaction : Drug interaction of Tacrine is with AMINOGLYCOSIDES , Halogenated inhalational anaesthetics, Beta Blockers , , , ,  Atropine , Suxamethonium/Succinylcholinechloride (Suxamethonium chloride) , Propafenone, Procainamide , Hydroxychloroquine , Chloroquine , Quinidine , Colistin, Clindamycin
Ref :-   Book : Martindale    Page : 687,401   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Drugs with neuromuscular blocking activity, such as the aminoglycosides, clindamycin, colistin, cyclopropane, and the halogenated inhalational anaesthetics, may antagonise the effects of tacrin. Those such as quinine, chloroquine, hydroxychloroquine, quinidine, procainamide, propafenone, lithium, and the beta blockers, that have the potential to aggravate myasthenia gravis, can reduce the effectiveness of treatment with parasympathomimetics. Prolonged bradycardia has also occurred in patients receiving beta blockers when given tacrin. Anticholinesterases, such as tacrin, can inhibit the metabolism of suxamethonium and enhance and prolong its action; combined use is not recommended. Ophthalmic use of anticholinesterases, such as ecothiopate, should be undertaken with care in patients receiving tacrin systemically for myasthenia gravis, because of possible additive toxicity. Antimuscarinics such as atropine antagonise the muscarinic effects of tacrin. Since tacrine is metabolized in the liver by the cytochrome P450 enzyme system (principally CYP1A2), drugs that either inhibit or induce the same isoenzymes may raise or lower plasma concentrations of tacrine, respectively. Tacrine may competitively inhibit the metabolism of other drugs that are also metabolised by the cytochrome P450 isoenzyme CYP1A2.
Ref :-   Book : Martindale    Page : 687,401   Edition : 37.  

►  Contraindication : Gastrointestinal obstruction, Urinary-Tract Obstruction, Bladder or Gastrointestinal surgery, Care is also required in patients with a history of asthma, obstructive pulmonary disease, Parkinson’s disease, or seizures, and in those, with, or at risk of developing, peptic ulcer disease, Patients with cardiovascular conduction disorders such as sick-sinus syndrome may be susceptible to the vagotonic effects of acetylcholinesterase inhibitors, Tacrine should be used with care in patients with impaired liver function or who have a history of such impairment.
Ref :-   Book : Martindale    Page : 395,400   Edition : 37.  
  ►  Mechanism of Action :   Inhibit acetylcholinesterase (AChE) by binding to the enzyme’s active site
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 129   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA Ficus Religiosa i.e. figs with same pathway.   Beilschmieda i.e.dalzells walnut with same pathway.   Skimmia laureola with same pathway.   Esenbeckia leicarpa with same pathway.   Corydalis cava with same pathway.   Catharanthus roseus i.e. sadabahar with same pathway.   Ervatamia hainanesis with same pathway.   Tabernaemontana i. e. Chandni. with same pathway.   Uncaria rhynchophylla with same pathway.   Himatanthus lancifolius e.i.agoniada. with same pathway.   Hippeastrum papilio with same pathway.   Huperzia serrata with same pathway.   Andrographis paniculata with same pathway.   Salsola oppositifolia with same pathway.   Salsola soda with same pathway.   Salsola soda with same pathway.   Salsola tragus with same pathway.   Crinum moorei e.i. lily with same pathway.   Nerine undulata with same pathway.   Scadoxus multiflorus i.e. lily with same pathway.   Sprekelia formosissima with same pathway.   Zephyranthes grandiflora with same pathway.   Kaempfera parviflora with same pathway.   Harpephyllum caffrum with same pathway.   Ashwagandha with same pathway.   Pistachios with same pathway.   Sclerocarya birrea with same pathway.   Spondias mombin with same pathway.   Gotu Kola with same pathway.   Black pepper with same pathway.   Amla with same pathway.  

  ►  Pathway with its reference as follows :-
  • Acetylcholistrase inhibitor --- ( Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetyl cholinesatrase inhibitor --- (Chandrashekher, S .B. "Phytopharmacology Of Ficus Religiosa". Pharmacogn 4.8 (2010): 195–199. Web. 9 Nov. 2016. )
  • Anti-anxiety --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249921/ .
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/ .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- VITAMIN C with Vitamin C blocks the formation of cell-damaging substances produced when tacrine is broken down by the body ..   MILK THRISTYL with Tacrine often caused elevations of a liver enzyme in the blood that indicates potential liver damage .But silymarin did reduce the number of severe enzyme elevations and it also reduced adverse stomach and intestinal side effects that are common in ind.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 401   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours.  
    Ref :-   Book : Martindale    Page : 401   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 401   Edition : 37.