Tacrine is a Medicine belongs to CHOLINESTERASE INHIBITORS group whose information about Brand can be referenced from   Book : Martindale    Page : 401   Edition : 37,

  ►   Brandname : Cognex

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg, Tablet with 30  mg, Tablet with 40  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 401   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe dementia Oral 10 mg Capsule QWK

Ref :-  Book : Martindale    Page : 401   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, cramp, anorexia, vivid dreams, tonic seizures, tonic- clonic seizures, diarrhea,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 128   Edition : 3,

►  Drug Interaction : Drug interaction of Tacrine is with Paracetamol , Clindamycin , Colistin, Zonisamide , Quinine , Chloroquine , Hydroxychloroquine , Quinidine , Procainamide , Propafenone, Felbamate, Mivacurium Chloride , Suxamethonium chloride, Fluvoxamine, Levodopa , Cimetidine , Estradiol cypionate , Levonorgestrel , Theophylline ,
Ref :-   Book : Martindale    Page : 687, 401, 1260   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : hepatic disorder,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 128   Edition : 3,
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, Ficus Religiosa i.e. figs with same pathway, Beilschmieda i.e.dalzells walnut with same pathway, Skimmia laureola with same pathway, Esenbeckia leicarpa with same pathway, Corydalis cava with same pathway, Catharanthus roseus i.e. sadabahar with same pathway, Ervatamia hainanesis with same pathway, Tabernaemontana i. e. Chandni. with same pathway, Uncaria rhynchophylla with same pathway, Himatanthus lancifolius e.i.agoniada. with same pathway, Hippeastrum papilio with same pathway, Huperzia serrata with same pathway, Andrographis paniculata with same pathway, Salsola oppositifolia with same pathway, Salsola soda with same pathway, Salsola soda with same pathway, Salsola tragus with same pathway, Crinum moorei e.i. lily with same pathway, Nerine undulata with same pathway, Scadoxus multiflorus i.e. lily with same pathway, Sprekelia formosissima with same pathway, Zephyranthes grandiflora with same pathway, Kaempfera parviflora with same pathway, Harpephyllum caffrum with same pathway, Ashwagandha with same pathway, Pistachios with same pathway, Sclerocarya birrea with same pathway, Spondias mombin with same pathway, Gotu Kola with same pathway, Black pepper with same pathway, Amla with same pathway,

  ►  Pathway with its reference as follows :-
  • Anti-anxiety --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Acetyl cholinesatrase inhibitor --- (Chandrashekher, S .B. "Phytopharmacology Of Ficus Religiosa". Pharmacogn 4.8 (2010): 195–199. Web. 9 Nov. 2016. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor m --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • acetyl cholinestrase inhibitor --- (Murray, Ana Paula. "Natural Ache Inhibitors From Plants And Their Contribution To Alzheimer’S Disease Therapy". Current Pharmacolo 11.4 (2014): n. pag. Web. 20 Jan. 2017. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- ( Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- ( Murray A. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr nuropharmacol. 2013;11(4):388–413. )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • Acetylcholistrase inhibitor --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249921/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744903/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN C with Vitamin C blocks the formation of cell-damaging substances produced when tacrine is broken down by the body ., MILK THRISTYL with Tacrine often caused elevations of a liver enzyme in the blood that indicates potential liver damage .But silymarin did reduce the number of severe enzyme elevations and it also reduced adverse stomach and intestinal side effects that are common in ind,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 401   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 401   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 401   Edition : 37,