Tamoxifen citrate is a Medicine belongs to Estrogen antagonist group whose information about Brand can be referenced from   Book : Martindale    Page : 856   Edition : 37  

  ►   Brandname : Nolvadex, Soltamox, Tamodex, Caditam, Cytotam, Mamofen
  ►  Strength : Tablet with 10 mg.  Tablet with 20 mg.  Solution with 10/5 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 853   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Breast cancer Oral 20 mg Tablet Dose: Given daily, in 2 divided doses or as a single daily dose.
2 Anovulatory infertility Oral 20 mg Tablet Dose: given daily on days 2 to 5 of the menstural cycle, increased if necessary in subsequent cycle up to 80 mg daily.

Ref :-  Book : Martindale    Page : 855   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Tamoxifen citrate' drug in  Polycystic Ovarian Disease  disease, then Please Precaution: Enhances effects of warfarin .

►  Side Effect : Hot flashes, Fluid retention, Nausea, Gastrointestinal intolerance, Vaginal bleeding or discharge, Pruritus vulvae, Rashes, Dry skin, Alopecia, Dizziness, Headache, Depression, Confusion, Fatigue, Muscle cramps, Transient thrombocytopenia, leucopenia, Hypertriglyceridaemia, Uterine fibroids, Hyperplasia, Polyps, Increased incidence of endometrial carcinoma, Suppression of menstruation may occur in premenopausal women and cystic ovarian swellings
Ref :-   Book : Martindale    Page : 853   Edition : 37.  

►  Drug Interaction : Drug interaction of Tamoxifen citrate is with ,  Bromocriptine
Ref :-   Book : Martindale    Page : 854   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  There is a risk of increased anticoagulant effect if tamoxifen is given with coumarin anticoagulants. Conversely, use with cytotoxic drugs may increase the risk of thromboembolic events; prophylactic anticoagulation should be considered. Tamoxifen increases the dopaminergic effect of bromocriptine. Use with inhibitors of cytochrome P450 isoenzyme CYP2D6 has been shown to reduce plasma concentrations of endoxifen, a tamoxifen metabolite
Ref :-   Book : Martindale    Page : 853   Edition : 37.  

►  Contraindication : Tamoxifen should not be used for treatment of infertility or the prophylaxis of breast cancer in women with a history of thromboembolic events., Care is also needed during or immediately after major surgery or prolonged immobility; all patients should be given prophylaxis against thrombosis., In patients being treated for infertility, tamoxifen should be stopped at least 6 weeks before surgery or long-term immobility and only restarted when the patient is fully mobile., Tamoxifen should be withdrawn immediately in any patient developing thromboembolism and appropriate treatment given. Treatment should not usually be restarted for infertility therapy but resumption of tamoxifen with prophylactic anticoagulation may be justified in selected patients with breast cancer., Women treated with tamoxifen should have routine gynaecological monitoring, and any abnormal symptoms such as menstrual irregularities, abnormal vaginal bleeding or discharge, or pelvic pain should be investigated
Ref :-   Book : Martindale    Page : 854   Edition : 37.  
  ►  Mechanism of Action :   It stimulates the secretion of pituitary gonadotrophic hormones, probably by blocking the negative feedback effect of oestrogens at receptor sites in the hypothalamus and pituitary It may also inhibit the production or release of cellular growth factors and induce apoptosis.
Ref :-   Book : Martindale    Page : 855,2291   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soya with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Genistein (Isoflavones) bind the estrogen receptors --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL --
  • https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA47&dq=Kokate .
  • +C.K.+Pharmaco .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- GAMMA LINOLENIC ACID ( GLA ) with Dietary Substance is Drug Enhancer.   TOCOTRIENOLS with Dietary Substance is Drug Enhancer.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Oppose the effects of ostrogen antagonists .   CITRUS FLAVONOIDS with It is found primarily in the peel of citrus fruits it interferes with the ability of tamoxifen to inhibit tumor growth ..  

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Renal, Faecal
    Ref :-   Book : Martindale    Page : 855   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   14 days,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 853   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   7 hours.  
    Ref :-   Book : Martindale    Page : 853   Edition : 37.