Telbivudine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1003   Edition : 37,

  ►   Brandname : Sebivo,Tyzeka

  ►  Strength : Tablet with 600  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hepatitis B Oral 600 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1003   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Cough, Dizziness, fatigue, gastrointestinal disturbance, abdominal pain, diarrhea, nausea, Rashes, arthralgia, myalgia, myopathy, malaise, Serum amylase, lipase and creatine phosphokinase levels may be increased, Raised serum alanine aminotransferase concentrations, peripheral neuropathy, Lactic acidosis, severe hepatomegaly, steatosis,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,

►  Drug Interaction : Drug interaction of Telbivudine is with Azole Antifungal, , Corticosteroids, Fibrates, Hmg-Coa Reductase Inhibitors,  Erythromycin , Penicillamine , Zidovudine,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Caution should be exercised when telbivudine is given with other drugs that alter renal function; serum concentrations of either drug may be affected. Telbivudine should be given with caution to patients taking other drugs associated with myopathy (such as azole antifungals, ciclosporin, corticosteroids, erythromycin, fibrates, HMG-CoA reductase inhibitors, penicillamine, and zidovudine).,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,


►  Contraindication : Telbivudine should be given with caution to patients with cirrhosis, hepatomegaly, or other risk factors for liver disease and should be withdrawn if there is a rapid increase in aminotransferase concentrations, progressive hepatomegaly or steatosis, or metabolic or lactic acidosis of unknown aetiology., Exacerbation of hepatitis B has been reported both during and after stopping treatment with entecavir, Liver function should be checked before treatment with rifampicin and special care should be taken in alcoholic patients or those with pre-existing liver disease who require regular monitoring during therapy.,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,
  ►  Mechanism of Action :   Telbivudine is phosphorylated intracellularly to the active triphosphate form, which competes with thymidine 5’-triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, thereby causing DNA chain termination and inhibiting hepatitis B viral replication.,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,


►    Plasma Half-life :
  Min value :-   30 hours,    Max value :-   53.6 hours,
Ref :-   Book : Martindale    Page : 1003   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1003   Edition : 37,