Temazepam is a Medicine belongs to Benzodiazepine group whose information about Brand can be referenced from   Book : Martindale    Page : 1137   Edition : 37,

  ►   Brandname : Restoril

  ►  Strength : Capsule with 7.5  mg, Capsule with 15  mg, Capsule with 22.5  mg, Capsule with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1137   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Insomnia Oral 10 20 mg Dose: Given at night.

Ref :-  Book : Martindale    Page : 1137   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 1 Year 12 Year Oral 1 mg/kg
2 <=18 Year Oral 20 30 mg

Ref :- Book : Martindale    Page : 1137   Edition : 37,
►  Side Effect : drowsiness, Sedation, muscle weakness, ataxia, headache, vertigo, Confusion, Depression, slurred speech, dysarthria, changes in libido, tremor, visual disturbances, urinary retention, urinary incontinence, gastrointestinal disturbance, changes in salivation, amnesia, jaundice, blood disorder, hypersenstivity, hypothermia, extrapyramidal disorders, hypersensitivity reactions,
Ref :-   Book : Martindale    Page : 1090   Edition : 37,

►  Drug Interaction : Drug interaction of Temazepam is with Zonisamide , Propafenone Hydrochloride , , Testosterone , Baclofen , Ethinylestradiol , Abatacept , Carbamazapine , Phenobarbital , Phenytoin , Mivacurium Chloride , Clozapine , Diphenhydramine , Sildenafil , Oxcarbazepine , Pemoline ,
Ref :-   Book : Martindale    Page : 1093   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most benzodiazepines is mediated primarily by the cytochrome P450 system, particularly the isoenzyme CYP2C19 and CYP3A4. Hence, adverse effect may also be produced by use with drugs that inhibit or induce oe are metabolised by use with drugs that inhibit or induce or are metabolised by these enzyme. Carbamazepine, phenobarbital, and phenytoin are all inducers of hepatic drug-metabolising enzymes. Therefore, in patients receiving long-term therapy with these drugs the metabolism of benzodiazepines may be enhanced. A reduction in temazepam metabolism caused by diphenhydramine may have contributed to perinatal death after ingestion of these drugs by the mother. Xanthine-containing beverages may be expected to decrease the incidence of benzodiazepine-induced drowsiness because of their CNS-stimulating effects and their ability to induce hepatic drug-metabolising enzymes. However, decreased drowsiness has only sometimes been seen and the actions of xanthines may themselves be decreased by heavy tobacco smoking.,
Ref :-   Book : Martindale    Page : 1093   Edition : 37,


►  Contraindication : CNS depression, coma, myasthenia gravis, sleep apnea,, muscle weakness, hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 1092   Edition : 37,
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at CNS neuronal synapses facilitating frequency of GABA- mediated chloride ion channel opening-enhance membrane hyperpolarization,
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- with Puerarin reduce the effect of temazepam,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1137   Edition : 37,


    ►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   15 hours,
    Ref :-   Book : Martindale    Page : 1137   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,