Temazepam is a Medicine belongs to Sedatives- hypnotics group whose information about Brand can be referenced from   Book : Martindale    Page : 1137   Edition : 37,

  ►   Brandname : Restoril,Norkotral Tema, Planum

  ►  Strength : Capsule with 7.5  mg, Capsule with 15  mg, Capsule with 22.5  mg, Capsule with 30  mg, Oral solution with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12, Martindale    Page : 1137   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1137   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Insomnia Oral 10 20 mg Dose: Given at night; exceptionally, doses up to 40 mg may be required. For premedication the usual oral dose is 20 to 40 mg given half to one hour beforehand.

Ref :-  Book : Martindale    Page : 1137   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Premedication before surgical or investigative procedure 1 Year 12 Year Oral 1 mg/kg
2 Premedication before surgical or investigative procedure 18Year Oral 20 30 mg

Ref :- Book : Martindale    Page : 1137   Edition : 37,
►  Side Effect : drowsiness, Sedation, muscle weakness, ataxia, vertigo, headache, Confusion, Depression, slurred speech, dysarthria, changes in libido, tremor, visual disturbances, urinary retention, urinary incontinence, gastrointestinal disturbance, changes in salivation, amnesia, paradoxical excitation, raised liver enzyme values, respiratory depression, ,
Ref :-   Book : Martindale    Page : 1090, 1137   Edition : 37,

►  Drug Interaction : Drug interaction of Temazepam is with Alcohol, antidepressants, Antipsychotic , General anaesthetics , opioid analgesics, ,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most banzodiazipines is mediated primarily by the cytochrome P450 system, particularly the isoenzymes CYP2C19 and CYP3A4. Hence, adverse effects may also be produce by use with drugs that inhibit or induce or metabolized by these isoenzymes. Benzodiazepines such as diazepam that are metabolised primarily by hepatic microsomal oxidation may be more susceptible to pharmacokinetic changes than those eliminated primarily by glucuronide conjugation.,
Ref :-   Book : Martindale    Page : 1093,1137   Edition : 37,


►  Contraindication : hepatic impairment, myasthenia gravis, pre-existing CNS depression or coma, respiratory depression, acute pulmonary insufficiency, renal impairment, sleep apnea, chronic pulmonary insufficiency, Temazepam is not appropriate for the treatment of chronic psychosis or for phobic or obsessional states, Caution is required in patients with organic brain changes particularly arteriosclerosis,
Ref :-   Book : Martindale    Page : 1992,1137   Edition : 37,
  ►  Mechanism of Action :   Bind to specific GABAA receptor subunits at CNS neuronal synapses facilitating frequency of GABA- mediated chloride ion channel opening-enhance membrane hyperpolarization,
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- with Puerarin reduce the effect of temazepam,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1137   Edition : 37,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   20 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 377   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 377   Edition : 12,