Temozolomide is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 857   Edition : 37,

  ►   Brandname : Zolom,Temodal

  ►  Strength : Capsule with nf  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 857   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Glioblastoma multiforme Oral 75 mg/m2 Capsule Dose: Given daily.
2 Glioblastoma multiforme IV 75 mg/m2 Injection Dose: Given daily.
3 Recurrent malignant gliomas Oral 200 mg/m2 Capsule o.d.
4 Progressive malignant gliomas Oral 200 mg/m2 Capsule o.d.
5 Malignant melanoma Oral 200 mg/m2 Capsule o.d.

Ref :-  Book : Martindale    Page : 857   Edition : 37, Martindale    Page : 858   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, gastrointestinal disturbance, anorexia, alopecia, fatigue, headache, Rashes, convulsion, insomnia, Somnolence, anxiety, Depression, Confusion, Dizziness, hemiparesis, aphasia, dysphagia, peripheral neuropathy, paraesthesia, speech disorders, tremor, memory impairment, Visual field defect, Blurred Vision, diplopia, hearing impairment, tinnitus, Deafness, Haemorrhage, deep vien thrombosis, peripheral edema, pulmonary embolism, hypersensitivity reactions, anaphylaxis, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme,
Ref :-   Book : Martindale    Page : 857   Edition : 37,

►  Drug Interaction : Drug interaction of Temozolomide is with Valproic acid(sodium valproate),
Ref :-   Book : Martindale    Page : 857   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Valproic acid decreases oral clearance of temozolomide by about 5 %,
Ref :-   Book : Martindale    Page : 857   Edition : 37,


►  Contraindication : pregnancy,
Ref :-   Book : Martindale    Page : 857   Edition : 37,
  ►  Mechanism of Action :   Methylates DNA and inhibits DNA synthesis and function,
Ref :-   Book : Martindale    Page : 857   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, Angeer with Another pathwayAnother pathway, Angeer with Another pathwayAnother pathway,

  ►  Pathway with its reference as follows :-
  • coumarin play important role in inhibition of cancer cell growth. --- ( Yin, S., Wei, W., Jian, F., & Yang, N. (2013). Therapeutic Applications of Herbal Medicines for Cancer Patients. Evidence-Based Complementary And Alternative Medicine, 2013, 1-15 )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )
  • 6-o-acyl-beta-d-glucosyl-beta-sitosterols.found in fig or anjeer have anticancer property. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727181/, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 857   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 857   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hour,    Max value :-   1.5 hour,
    Ref :-   Book : Martindale    Page : 857   Edition : 37,