Tenecteplase is a Medicine belongs to Fibrinolytic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1547   Edition : 37  

  ►   Brandname : Metalyse, TNKase
  ►  Strength : Injection with 50 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute myocardial infarction IV 30 mg Injection Dose: For patients those weight less than 60 kg
2 Acute myocardial infarction IV 50 mg Injection Dose: For patients those weight 90 kg or above

Ref :-  Book : Martindale    Page : 1547   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Fever, Chills, Back pain, Abdominal pain, Nausea, Vomiting, Guillain-Barré syndrome, Hypotension, Bradycardia, Arrhythmias, Pulmonary embolism, Acute renal failure, Haemorrhage
Ref :-   Book : Martindale    Page : 1539,1547   Edition : 37.  

►  Drug Interaction : Drug interaction of Tenecteplase is with Dextran
Ref :-   Book : Martindale    Page : 1541,1547   Edition : 3.  


  ►    Mechanism of Drug Drug Interaction :  Oral anticoagulants, heparin, and antiplatelet drugs such as aspirin are often used with streptokinase, but may increase the risk of haemorrhage. The risk may also be increased with dextrans, and with other drugs that affect coagulation or platelet function
Ref :-   Book : Martindale    Page : 1541,1547   Edition : 37.  


►  Contraindication : Active internal bleeding or known bleeding diathesis, Intracranial or intraspinal surgery or trauma within 2 months, Stroke within 2 months, Severe uncontrolled hypertension
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 399   Edition : 3.  
  ►  Mechanism of Action :   Proteolytically activate plasminogen to form plasmin, which digests fibrin to fibrin degradation products
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 399   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism)
Ref :-   Book : Martindale    Page : 1547   Edition : 37.  

►    Plasma Half-life :   Min value :-   20 minutes,    Max value :-   24 minutes.  
Ref :-   Book : Martindale    Page : 1547   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA