Tenecteplase is a Medicine belongs to Thrombolytics Drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1547   Edition : 37,

  ►   Brandname : Metalyse,TNKase

  ►  Strength : Injection with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Myocardial infarction IV 30 mg Injection Dose: for patients less than 60 kg.
2 Myocardial infarction IV 50 mg Injection Dose: for patients 90 kg or above.
3 Acute myocardial infarction IV 30 mg Injection Dose: based on body-weight and ranges from 30 mg in patients less than 60 kg to a maximum of 50 mg in those 90 kg or above.

Ref :-  Book : Martindale    Page : 1547   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : fever, chill, back pain, abdominal pain, nausea, vomiting, Guillain-Barré syndrome,
Ref :-   Book : Martindale    Page : 1539   Edition : 37,

►  Drug Interaction : Drug interaction of Tenecteplase is with Ropinirole , Heparin , Liothyronine Sodium (T3) , Dextran,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Oral anticoagulants, heparin, and antiplatelet drugs such as aspirin are often used with streptokinase, but may increase the risk of haemorrhage. The risk may also be increased with dextrans, and with other drugs that affect coagulation or platelet function,
Ref :-   Book : Martindale    Page : 1541   Edition : 37,


►  Contraindication : peptic ulcer disease, oesophageal varices, ulcerative colitis , pancreatitis,
Ref :-   Book : Martindale    Page : 1539   Edition : 37,
  ►  Mechanism of Action :   Proteolytically activate plasminogen to form plasmin, which digests fibrin to fibrin degradation products,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 399   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1547   Edition : 37,


►    Plasma Half-life :
  Min value :-   0.33 hours,    Max value :-   0.4 hours,
Ref :-   Book : Martindale    Page : 1547   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,