Tenofovir disoproxil fumarate is a Medicine belongs to group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1003   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Lactic acidosis, Hepatotoxicity, Osteonecrosis has been reported, particularly in patients with advanced HIV disease or long-term exposure to combination antiretroviral therapy
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 671   Edition : 3.   Martindale    Page : 1004   Edition : 37.  

►  Drug Interaction : Drug interaction of Tenofovir disoproxil fumarate is with fumanephrotoxic,  NA

  ►    Mechanism of Drug Drug Interaction :  A 300-mg dose of tenofovir increased the didanosineAUC by 44-60%, probably as a consequence of inhibition of purine nucleoside phosphorylase by both tenofovir and tenofovir monophosphate (Robbins et al., 2003). These two drugs probably should not be used together; if the combination is essential, the dose of didanosine should be reduced from 400 to 250 mg/day (Chapman et al., 2003)
Ref :-   Book : Martindale    Page : 1003   Edition : 37.  


►  Contraindication : Renal failure
Ref :-   Book : Martindale    Page : 1003   Edition : 37.  
  ►  Mechanism of Action :   Tenofovir is a nucleotide reverse transcriptase inhibitor with antiviral activity against HIV-1 and hepatitis B and Tenofovir is converted intracellularly to the diphosphate. This diphosphate halts the DNA synthesis of HIV through competitive inhibition of reverse transcriptase and incorporation into viral DNA
Ref :-   Book : Martindale    Page : 1003   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Calophyllum lanigeum i.e. Antamul with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Calanolide-A have anti HIV effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL --
  • https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   17 hours.  
    Ref :-   Book : Martindale    Page : 1003   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1003   Edition : 37.