Tenofovir/Tenofovir disoproxil fumarate is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1005   Edition : 37  

  ►   Brandname : Viread
  ►  Strength : Tablet with 300 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 300 mg Tablet o.d.
2 Chronic hepatitis B infection Oral 300 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1004   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antiretroviral Oral 8 mg/kg Tablet o.d.
2 Antiretroviral 35 kg Oral 300 mg Tablet o.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1168   Edition : 19  
►  Organ Affected Nephrotoxicity –(Tubular cell toxicity)  

►  Side Effect : Anorexia, Abdominal pain, Diarrhea, Dyspepsia, Flatulence, Nausea, Vomiting, Dizziness, Fatigue, Headache, Skin rashes, Hypophosphataemia, Raised liver enzyme values, Hepatitis, Nephritis, Nephrogenic diabetes, Bone pain, Immune reconstitution syndrome, Lipodystrophy, central obesity, Dorsocervical fat enlargement , Peripheral wasting, Facial wasting, Breast enlargement, Cushingoid appearance, Hypertriglyceridaemia, Hypercholesterolaemia, Mitochondrial dysfunction, Abnormal behaviour, Anaemia, Convulsions, Hyperlipasaemia, Hypertonia, Neutropenia, Elevated creatine phosphokinase, Myalgia, Myositis
Ref :-   Book : Martindale    Page : 1004   Edition : 37.  

►  Drug Interaction : Drug interaction of Tenofovir/Tenofovir disoproxil fumarate is with Didanosine, Abacavir, Atazanavir, Lopinavir
Ref :-   Book : Martindale    Page : 1004   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Use of tenofovir disoproxil fumarate with nephrotoxic drugs or with other drugs eliminated by active tubular secretion is not recommended; if such use is unavoidable, renal function should be monitored weekly. Tenofovir increases the plasma concentrations of didanosine. Once daily triple nucleoside regimens of tenofovir and lamivudine with either abacavir or didanosine are associated with a high level of treatment failure and of emergence of resistance, and should be avoided. Tenofovir increases the plasma concentrations of didanosine. Decreased plasma concentrations of atazanavir and increased plasma concentrations of tenofovir occur when tenofovir is given with atazanavir; the effect is significantly reduced when ritonavir is added as a booster. Use of ritonavir-boosted lopinavir with tenofovir modestly increases the plasma concentrations of tenofovir.
Ref :-   Book : Martindale    Page : 1004   Edition : 37.  


►  Absolute Contraindication : Rapid increase in aminotransferase concentrations   progressive hepatomegaly or steatosis   or metabolic or lactic acidosis of unknown aetiology.  

►  Contraindication : Lactic acidosis, Hepatotoxicity
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 671   Edition : 3.  
  ►  Mechanism of Action :   Tenofovir is a nucleotide reverse transcriptase inhibitor with antiviral activity against HIV-1 and hepatitis B.
Ref :-   Book : Martindale    Page : 1004   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Castarospermum austrate i.e. Mareton bay Chestnut with Another pathway.   Clove with Another pathway.  

  ►  Pathway with its reference as follows :-
  • anti viral effect --- (Antiviral Properties of Garlic Cloves Juice Compared with Onion Bulbs Juice Against Potato Virus Y (PVY). (2016). Journal Of American Science, 6(8). )
  • Anti HIV. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .
  • http://www.jofamericanscience.org/journals/am-sci/am0608/39_2830_am0608_302_310.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1004   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   18 hours.  
    Ref :-   Book : Martindale    Page : 1004   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1004   Edition : 37.