Terbinafine is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 594   Edition : 37,

  ►   Brandname : Lamisil, SolvEasy, Tamsil, Amiada, Dermatin, Exifine, DesenexMax

  ►  Strength : Tablet with 250  mg, Cream with 1  %, Gel with 1  %, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12, Martindale    Page : 595   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tinea cruris Oral 250 mg Tablet Dose: given daily for 2 to 4 weeks
2 Tinea pedis Oral 250 mg Tablet Treatment may be continued for up to 6 weeks weeks
3 Tinea corporis Oral 250 mg Tablet It is a 4-week course
4 Topical 1 % Cream/Gel/solution o.d/b.d Dose given for 1 to 2 weeks to treat tinea corporis and tinea cruris; a 1-week course is recommended for tinea pedis. A 2-week course of treatment is used in cutaneous candidiasis and pityriasis versicolor.
5 Dermatophyte infections of the nails Oral 250 mg Tablet o.d. Dose: Given daily for 6 to 12 weeks although longer treatment may be necessary in toe-nail infections.

Ref :-  Book : Martindale    Page : 595   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Dermatophyte infections of the skin and nails 1 Year In those weighing 10 to 20 kg Oral 62.5 mg o.d.
2 Dermatophyte infections of the skin and nails 1 Year In those weighing 20 to 40 kg Oral 125 mg o.d.
3 Dermatophyte infections of the skin and nails 1 Year In those weighing over 40 kg Oral 250 mg o.d.

Ref :- Book : Martindale    Page : 595   Edition : 37,
►  Side Effect : nausea, diarrhoea, mild abdominal pain, Loss or disturbance of taste, anorexia, weight loss, headache, Skin reactions, Rashes, Urticaria, arthralgia, myalgia, cholestasis, hepatitis, jaundice, neutropenia, thrombocytopenia, agranulocytosis, pancytopenia, ,
Ref :-   Book : Martindale    Page : 594   Edition : 37,

►  Drug Interaction : Drug interaction of Terbinafine is with Tricyclic antidepressants, Antiarrhythmics, , Beta Blockers , selective serotonin reuptake inhibitors, ,  Propafenone,
Ref :-   Book : Martindale    Page : 595   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Plasma concentrations of terbinafine may be increased by drugs that inhibit its metabolism by cytochrome P450, such as cimetidine, and decreased by drugs that induce cytochrome P450 enzymes, such as rifampicin. Menstrual disturbances including breakthrough bleeding have been reported in patients taking oral contraceptives and terbinafine. Terbinafine has been shown in vitro to inhibit metabolism mediated by the cytochrome P450 isoenzyme CYP2D6. Hence it may affect the plasma concentrations of drugs predominantly metabolised by this enzyme such as tricyclic antidepressants, antiarrhythmics (such as flecainide and propafenone), beta blockers, SSRIs, and type B MAOIs.,
Ref :-   Book : Martindale    Page : 594   Edition : 37,


►  Contraindication : renal impairment, Breast feeding, Terbinafine should not be used in patients with existing liver disease and liver function tests should be performed in all patients before starting oral therapy.,
Ref :-   Book : Martindale    Page : 594   Edition : 37,
  ►  Mechanism of Action :   mechanism of action is inhibition of fungal squalene epoxidase, blocking ergosterol biosynthesis. Increased intracellular squalene also impairs cell growth.,
Ref :-   Book : Goodman    Page : 1586   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 595   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 595   Edition : 37,