Terbinafine is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 595   Edition : 37,

  ►   Brandname : Exifine,Lamisil,Terbifin,DesenexMax

  ►  Strength : Tablet with 250  mg, Cream with 1  %, Gel with 1  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tinea cruris Oral 250 mg o.d. Dose: Given for 2-4 weeks.
2 Tinea pedis Oral 250 mg o.d. Dose: Given for up to 6 weeks.
3 Tinea pedis Oral 250 mg o.d. Dose: Given for 4 weeks.
4 Tinea corporis Topical 1 % Cream o.d/b.d Dose: Given for 1 to 2 weeks.
5 Tinea corporis Topical 1 % Gel o.d/b.d Dose: Given for 1 to 2 weeks.
6 Tinea corporis Topical 1 % Solution o.d/b.d Dose: Given for 1 to 2 weeks.
7 Tinea cruris Topical 1 % Solution o.d/b.d Dose: Given for 1 to 2 weeks.
8 Tinea cruris Topical 1 % Gel o.d/b.d Dose: Given for 1 to 2 weeks.
9 Tinea cruris Topical 1 % Cream o.d/b.d Dose: Given for 1 to 2 weeks.
10 Tinea pedis Topical 1 % Cream o.d/b.d Dose: Given for 1 weeks.
11 Tinea pedis Topical 1 % Gel o.d/b.d Dose: Given for 1 weeks.
12 Tinea pedis Topical 1 % Solution o.d/b.d Dose: Given for 1 weeks.
13 Dermatophyte infections Oral 250 mg o.d.

Ref :-  Book : Martindale    Page : 594   Edition : 37, Martindale    Page : 595   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Dermatophyte infections <1 Year 10 to 20 kg Oral 62.5 mg Suspension o.d.
2 Dermatophyte infections <1 Year 20 to 40 kg Oral 125 mg Suspension o.d.
3 Dermatophyte infections <1 Year Over 40 kg Oral 250 mg Suspension o.d.

Ref :- Book : Martindale    Page : 595   Edition : 37,
►  Side Effect : nausea, diarrhoea, mild abdominal pain, Loss or disturbance of taste, anorexia, weight loss, headache, skin reaction, rash, Urticaria, arthralgia, myalgia, angioedema, photosensitivity, Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatic failure, death, paraesthesia, hypoaesthesia, Dizziness, malaise, fatigue, alopecia, neutropenia, thrombocytopenia, Depression, anxiety, systemic lupus erythematosus, granulocytosis, liver transplantation,
Ref :-   Book : Martindale    Page : 594   Edition : 37,

►  Drug Interaction : Drug interaction of Terbinafine is with Cimetidine , Rifampicin , , Mivacurium Chloride , Pramlintide , Acarbose ,
Ref :-   Book : Martindale    Page : 595   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Plasma concentrations of terbinafine may be increased by drugs that inhibit its metabolism by cytochrome P450, such as cimetidine, and decreased by drugs that induce cytochrome P450 enzymes, such as rifampicin. Terbinafine has been shown in vitro to inhibit metabolism mediated by the cytochrome P450 isoenzyme CYP2D6. Hence it may affect the plasma concentrations of drugs predominantly metabolised by this enzyme such as tricyclic antidepressants, beta blockers, SSRIs, and type B MAOIs.,
Ref :-   Book : Martindale    Page : 595   Edition : 37,


►  Contraindication : psoriasis, renal impairment, hepatic disease,
Ref :-   Book : Martindale    Page : 594   Edition : 37,
  ►  Mechanism of Action :   mechanism of action is inhibition of fungal squalene epoxidase, blocking ergosterol biosynthesis. Increased intracellular squalene also impairs cell growth.,
Ref :-   Book : Goodman    Page : 1586   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 595   Edition : 37,


►    Plasma Half-life :
  Min value :-   17 hours,    Max value :-   36 hours,
Ref :-   Book : Martindale    Page : 595   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 595   Edition : 37,