Terbutaline is a Medicine belongs to sympathomimetic used in asthama group whose information about Brand can be referenced from   Book : Martindale    Page : 1255   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Bricanyl,Monovent,Brethine,Ascoril

  ►  Strength : Tablet with 2.5  mg, Tablet with 5  mg, Injection with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, SC,
Reference :-   Book : Martindale    Page : 1254   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute bronchospasm inhalation 250 500 micrograms Aerosol
2 Acute bronchospasm Oral 2.5 3 mg t.i.d.
3 Severe bronchospasm inhalation 2.5 10 mg nebuliser Dose: Given up to 4 times daily.
4 Unresponsive bronchospasm inhalation 2.5 10 mg nebuliser Dose: Given up to 4 times daily.
5 Severe forms of bronchospasm SC 250 500 micrograms Injection Dose: Given up to 4 times daily.
6 Severe forms of bronchospasm IM 250 500 micrograms Injection Dose: Given up to 4 times daily.
7 Severe forms of bronchospasm slow i.v 3 5 microgram/ml Injection Dose: Given at a rate of 0.5 to 1 mL/minute.
8 Premature labour IV infusion 5 micrograms/minute Injection

Ref :-  Book : Martindale    Page : 1254   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Bronchospasm <=5Year inhalation 500 micrograms Aerosol q.i.d.
2 Bronchospasm 1 Month 7 Year Oral 75 mcg/kg t.i.d.
3 Bronchospasm 7 Year 15 Year Oral 2.5 mg b.d/t.i.d
4 Severe bronchospasm >3 Year 10 kg inhalation 2 mg nebuliser b.d.
5 Severe bronchospasm >3 Year 10 kg inhalation 2 mg nebuliser q.i.d.
6 Unresponsive bronchospasm >3 Year 10 kg inhalation 2 mg nebuliser q.i.d.
7 Unresponsive bronchospasm >3 Year 10 kg inhalation 2 mg nebuliser b.d.
8 Severe bronchospasm 3 Year 5 Year 15 kg inhalation 3 mg nebuliser b.d.
9 Severe bronchospasm 3 Year 5 Year 15 kg inhalation 3 mg nebuliser q.i.d.
10 Unresponsive bronchospasm 3 Year 5 Year 15 kg inhalation 3 mg nebuliser q.i.d.
11 Unresponsive bronchospasm 3 Year 5 Year 15 kg inhalation 3 mg nebuliser b.d.
12 Severe bronchospasm 6 Year 7 Year 20 kg inhalation 4 mg nebuliser b.d.
13 Severe bronchospasm 6 Year 7 Year 20 kg inhalation 4 mg nebuliser q.i.d.
14 Unresponsive bronchospasm 6 Year 7 Year 20 kg inhalation 4 mg nebuliser q.i.d.
15 Unresponsive bronchospasm 6 Year 7 Year 20 kg inhalation 4 mg nebuliser b.d.
16 Severe bronchospasm <=8 Year greater than 25 kg inhalation 5 mg nebuliser b.d.
17 Severe bronchospasm <=8 Year greater than 25 kg inhalation 5 mg nebuliser t.i.d.
18 Unresponsive bronchospasm <=8 Year greater than 25 kg inhalation 5 mg nebuliser t.i.d.
19 Unresponsive bronchospasm <=8 Year greater than 25 kg inhalation 5 mg nebuliser b.d.
20 Severe bronchospasm 2 Year 13 Year SC 10 micrograms/kg Injection
21 Severe bronchospasm 2 Year 13 Year IV 10 micrograms/kg Injection
22 Severe bronchospasm continuous i.v infusion 2 4 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1254   Edition : 37,
►  Organ Affected Liver Disease – (High Ist Pass Metabolism)  

►  Side Effect : fine tremor of skeletal muscle, palpitations, tachycardia, nervous tension, headache, peripheral vasodilatation, myocardial ischaemia, hypersensitivity reactions, paradoxical bronchospasm, angioedema, Urticaria, hypotension, collapse, muscle cramp,
Ref :-   Book : Martindale    Page : 1246   Edition : 37,

►  Drug Interaction : Drug interaction of Terbutaline is with other,  Gonadorelin , Corticosteroids, Tenecteplase ,
Ref :-   Book : Martindale    Page : 1247   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  beta2 agonists with corticosteroids, diuretics, or xanthines increases the risk of hypokalaemia, and monitoring of potassium concentrations is recommended in severe asthma, where such combination therapy is common,
Ref :-   Book : Martindale    Page : 1245   Edition : 37,


►  Absolute Contraindication : Patients hypersensitive to it.  

►  Contraindication : hyperthyroidism, myocardial infraction, Arrhythmia, , Diabetes mellitus,
Ref :-   Book : Martindale    Page : 1246   Edition : 37,
  ►  Mechanism of Action :   Terbutaline sulfate is a direct-acting sympathomimetic with mainly beta-adrenergic activity and a selective action on beta2 receptors (a beta2 agonist).,
Ref :-   Book : Martindale    Page : 1254   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 1254   Edition : 37,


►    Plasma Half-life :
  Min value :-   16 hours,    Max value :-   20 hours,
Ref :-   Book : Martindale    Page : 1254   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,