Terbutaline is a Medicine belongs to sympathomimetic used in asthama group whose information about Brand can be referenced from   Book : Martindale    Page : 1254   Edition : 37,

  ►   Brandname : Bricanyl, Aerodur, Brethine, Aerodur, Contimit

  ►  Strength : Tablet with 2.5  mg, Tablet with 5  mg, Injection with 1  mg/ml, Oral Suspension with   , inhalation aerosol with   , nebuliser with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12, Martindale    Page : 1255   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation, Oral, SC/IM/slow IV, IV infusion,
Reference :-   Book : Martindale    Page : 1254   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute bronchospasm inhalation 250 500 micrograms Aerosol The maximum recommended daily dose varies; in the UK a maximum of 2 mg is suggested, whereas in some other countries higher doses of up to 4 mg are allowed.
2 Acute bronchospasm Oral 2.5 3 mg t.i.d. Dose: increased up to 5 mg three times daily as necessary. Modified-release tablets are also available; the usual adult dose is 7.5 mg twice daily.
3 Severe or unresponsive bronchospasm inhalation 2.5 10 mg nebuliser Dose: Given up to 4 times daily. Single-dose units or a suitable dilution of a concentrated solution containing terbutaline sulfate 1% are used for this purpose.
4 Severe forms of bronchospasm SC/IM/slow IV 250 500 micrograms Injection Dose: Given up to 4 times daily. Terbutaline sulfate may also be given by intravenous infusion, as a solution containing 3 to 5 micrograms/mL at a rate of 0.5 to 1 mL/minute.
5 Premature labour IV infusion 5 micrograms/minute Injection Dose: increased by 2.5 micrograms/minute at intervals of 20 minutes until contractions stop.

Ref :-  Book : Martindale    Page : 1254   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Reversible airway obstruction, including nocturnal asthma, and prevention of exercised-induced bronchospasm 5 Year inhalation 500 micrograms inhalation aerosol q.i.d.
2 Reversible airway obstruction, including nocturnal asthma, and prevention of exercised-induced bronchospasm 1 Month 7 Year inhalation 75 mcg/kg inhalation aerosol t.i.d.
3 Reversible airway obstruction, including nocturnal asthma, and prevention of exercised-induced bronchospasm 7 Year 15 Year inhalation 2.5 mg inhalation aerosol t.i.d/q.i.d
4 Reversible airway obstruction, including nocturnal asthma, and prevention of exercised-induced bronchospasm 15 Year
5 Severe or unresponsive bronchospasm 3 Year 10 kg inhalation 2 mg nebuliser b.d/q.i.d
6 Severe or unresponsive bronchospasm 3 Year 5 Year 15 kg inhalation 3 mg nebuliser b.d/q.i.d
7 Severe or unresponsive bronchospasm 6 Year 7 Year 20 kg inhalation 4 mg nebuliser b.d/q.i.d
8 Severe or unresponsive bronchospasm 8 Year 25 kg or more inhalation 5 mg nebuliser b.d/q.i.d
9 Severe bronchospasm 2 Year 15 Year SC/slow IV 10 microgram/kg Injection q.i.d.
10 Severe bronchospasm 15 Year
11 Severe bronchospasm continuous i.v infusion 2 4 microgram/kg Injection

Ref :- Book : Martindale    Page : 1254   Edition : 37,
►  Side Effect : Fine tremor of skeletal muscle (particularly the hands),, palpitations, tachycardia, nervous tension, headache, peripheral vasodilatation, hypokalaemia, myocardial ischaemia, hypersensitivity reactions, paradoxical bronchospasm, angioedema, Urticaria, hypotension, collapse, ,
Ref :-   Book : Martindale    Page : 1246,1253   Edition : 37,

►  Drug Interaction : Drug interaction of Terbutaline is with Corticosteroids, Diuretics, Xanthines,  NA

  ►    Mechanism of Drug Drug Interaction :  Terbutaline and other beta2 agonists with corticosteroids, diuretics, or xanthines increases the risk of hypokalaemia, and monitoring of potassium concentrations is recommended in severe asthma, where such combination therapy is common,
Ref :-   Book : Martindale    Page : 1254,1245   Edition : 37,


►  Contraindication : An increased tendency for bleeding after caesarean section has been reported in patients being treated with terbutaline for preterm labour. Should bleeding occur, an intravenous injection of propranolol 1 to 2 mg may be given. , Terbutaline and other beta agonists should be given with caution in hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, hypertension, and diabetes mellitus (especially on intravenous use—blood glucose should be monitored since ketoacidosis has been reported)., In severe asthma particular caution is also required to avoid inducing hypokalaemia, In women being treated for premature labour the risk of pulmonary oedema means that the patient’s state of hydration and cardiac and respiratory function should be monitored very carefully, Eclampsia and severe preeclampsia are also contra-indications, Other contra-indications include intra-uterine infection, intrauterine fetal death, antepartum haemorrhage (which requires immediate delivery), placenta praevia, and cord compression; beta2 agonists should not be used for threatened miscarriage.,
Ref :-   Book : Martindale    Page : 1247,1253   Edition : 37,
  ►  Mechanism of Action :   Terbutaline sulfate is a direct-acting sympathomimetic with mainly beta-adrenergic activity and a selective action on beta2 receptors (a beta2 agonist).,
Ref :-   Book : Martindale    Page : 1254   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 1254   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA