Terlipressin is a Medicine belongs to Vasopressin agonist group whose information about Brand can be referenced from   Book : Martindale    Page : 2633   Edition : 37   Martindale    Page : 2632   Edition : 37  

  ►   Brandname : Glypressin, Haemopressin, Variquel
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2632   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV
Reference :-   Book : Martindale    Page : 2632   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oesophageal variceal bleeding IV 1 2 mg Injection Dose: Followed by 1 to 2 mg every 4 to 6 hours if necessary, until bleeding is controlled, for up to 72 hours.

Ref :-  Book : Martindale    Page : 2632   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Marked pallor, Pounding headache, Vertigo, Sweating, Tremor, Nausea, Vomiting, Diarrhoea, Eructation, Cramps, Desire to defaecate, Hyponatraemia, Hypersensitivity reactions, Urticaria, Bronchoconstriction, Anaphylactic shock, Cardiac arrest, chest pain, Myocardial ischaemia, Infarction, Arrhythmias, Bradycardia, Hypertension, Peripheral vasoconstriction, Thrombosis, Local irritation at the injection site
Ref :-   Book : Martindale    Page : 2633,2650   Edition : 37.  

►  Drug Interaction : Drug interaction of Terlipressin is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Patients with chronic nephritis with nitrogen retention, It should be avoided or given only with extreme care, and in small doses, to patients with vascular disease, especially of the coronary arteries. , It should be given with care to patients with conditions which might be aggravated by water retention including asthma, epilepsy, migraine, and heart failure, Fluid intake should be adjusted to avoid hyponatraemia and water intoxication.
Ref :-   Book : Martindale    Page : 2633,2650   Edition : 37.  
  ►  Mechanism of Action :   Terlipressin is an inactive prodrug which is slowly converted in the body to lypressin. It has a direct antidiuretic action on the kidney, increasing tubular reabsorption of water. It also constricts peripheral blood vessels and causes contraction of the smooth muscle of the intestine, gallbladder, and urinary bladder
Ref :-   Book : Martindale    Page : 2632,2651   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA