Testosterone is a Medicine belongs to Androgenic and anabolic steroids group whose information about Brand can be referenced from   Book : Martindale    Page : 2342   Edition : 37,

  ►   Brandname : Aquaviron,Nuvir,Sustanon 100,Andropatch,Intrinsa,Nebido,Androderm,AndroGel,Delatestryl,Striant,Testim

  ►  Strength : Injection with 100  mg/ml, Injection with 200  mg/ml, Transdermal Patch with 2.5  mg, Transdermal Patch with 5  mg, Injection with 75  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, SC, Transdermal,
Reference :-   Book : Martindale    Page : 2340   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Male hypogonadal disorders 100 600 mg Dose: Given as subcutaneous implant.
2 Male hypogonadal disorders Transdermal 2.5 7.5 mg Transdermal Patch Dose: Given daily.
3 Male hypogonadal disorders IM 50 mg Injection bis in 7 d.
4 Male hypogonadal disorders IM 50 mg Injection t.i.w.

Ref :-  Book : Martindale    Page : 2340   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Sexual Maturation in boys <12 Year Oral 40 mg
2 Sexual Maturation in boys IM 25 50 mg/m2 Injection
3 Sexual Maturation in boys IM 25 50 mg/m2 Injection

Ref :- Book : Martindale    Page : 2340   Edition : 37,
►  Side Effect : retention of sodium and water, oedema, hypercalcaemia, impaired glucose tolerance, increases low density- lipoprotein cholesterol, decreases high-density- lipoprotein cholesterol, increases haematocrit, suppression of clotting factors, headache, Depression, gastrointestinal bleeding, jaundice, cholestatic hepatitis, testicular atrophy, epididymitis, bladder irritability, priapism, Gynaecomastia, prostatic hyperplasia, accelerates growth of malignant neoplasms of the prostate, precocious sexual development, Prostate cancer, Cerebrovascular accident, hepatotoxicity,
Ref :-   Book : Martindale    Page : 2339   Edition : 37,

►  Drug Interaction : Drug interaction of Testosterone is with Cyclosporine , Levothyroxine, Warfarin , Potassium Permanganate , Lamotrigine ,
Ref :-   Book : Martindale    Page : 2337   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  As androgens and anabolic steroids can alter glucose metabolism, doses of insulin or oral antidiabetics may need adjustment.,
Ref :-   Book : Martindale    Page : 2337   Edition : 37,


►  Contraindication : Hypocalcaemia, hepatic impairment, Carcinoma prostate, pregnancy,
Ref :-   Book : Martindale    Page : 2339   Edition : 37,
  ►  Mechanism of Action :   testosterone acts intracellularly in target cells. In skin, prostate, seminal vesicles, and epididymis, it is converted to 5α-dihydrotestosterone by 5α-reductase. In these tissue dihydrotestosterone is the dominant androgen.Testosterone and dihydrotestosterone bind to the intracellular androgen receptor, initiating a series of events similar to those described above for estradiol and progesterone, leading to growth, differentiation, and synthesis of a variety of enzymes and other functional proteins.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 735   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with , Panax Ginseng with Another pathway,

  ►  Pathway with its reference as follows :-
  • Ginsenosides and Panaxosides (Triterpenoid Saponins) stimulate testosteron --- ( Deniells, S. (2014). Ashwagandha may promote healty testeosteron level in men. )
  • It increase blood testosterone level --- (Gunnels, T. & Bloomer, R. (2014). Increasing Circulating Testosterone: Impact of Herbal Dietary Supplements. J Plant Biochem Physiol, 2(2). )

  •   ►  URL -- http://www.nutraingredients-usa.com/Research/Ashwagandha-may-promote-healthy-testosterone-production-in-men-Clinical-data, http://www.esciencecentral.org/journals/increasing-circulating-testosterone-impact-of-herbal-dietary-supplements.2329-9029.1000130.php?aid=28009,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CATS CLAY with effect the level of female sex hormone ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2339   Edition : 37,


    ►    Plasma Half-life :   Min value :-   0.16 hours,    Max value :-   1.66 hours,
    Ref :-   Book : Martindale    Page : 2339   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,