Tetrabenazine is a Medicine belongs to Drugs that act in the Central Nervous System group whose information about Brand can be referenced from   Book : Martindale    Page : 2633   Edition : 37,

  ►   Brandname : Xenazine

  ►  Strength : Tablet with 12.5  mg, Tablet with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2633   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chorea, ballism, and other organic CNS movement disorders Oral 25 mg Tablet t.i.d.
2 Huntington's chorea Oral 12.5 mg Tablet Dose: Given in the morning is recommended, which may be increased after one week to 25 mg daily given in 2 divided doses. The dose may then be gradually increased by 12.5 mg daily at weekly intervals according to response.
3 Tardive dyskinesia Oral 12.5 mg Tablet Dose: Given daily is recommended initially, subsequently titrated according to response.

Ref :-  Book : Martindale    Page : 2633   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition : ,
►  Side Effect : Orthostatic hypotension, symptoms of extrapyramidal dysfunction, Gastrointestinal disturbances, Depression, ,
Ref :-   Book : Martindale    Page : 2633   Edition : 37,

►  Drug Interaction : Drug interaction of Tetrabenazine is with Monoamine Oxidase Inhibitor,  Levodopa ,
Ref :-   Book : Martindale    Page : 2633   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Tetrabenazine may diminish the effects of levodopa and exacerbate the symptoms of parkinsonism. Tetrabenazine should not be started until at least 20 days after stopping reserpine in order to avoid major depletion of serotonin and noradrenaline in the CNS. Use of tetrabenazine immediately after a course of an MAOI may lead to confusion, restlessness, and disorientation; tetrabenazine should not be given with, or within 14 days of stopping, such therapy. Use of tetrabenazine immediately after a course of an MAOI may lead to confusion, restlessness, and disorientation; tetrabenazine should not be given with, or within 14 days of stopping, such therapy.,
Ref :-   Book : Martindale    Page : 2633   Edition : 37,


►  Contraindication : hepatic impairment, Actively suicidal patients or in cases of untreated or inadequately treated depression, Tetrabenazine may exacerbate the symptoms of parkinsonism, It may cause drowsiness, affected patients should not drive or operate machinery,
Ref :-   Book : Martindale    Page : 2633   Edition : 37,
  ►  Mechanism of Action :   It blocks the ability of aminergic transmitter vesicles to take up and store biogenic amines, probably by interfering with the vesicular membrane-associated transporter. This effect occurs throughout the body, resulting in depletion of norepinephrine, dopamine, and serotonin in both central and peripheral neurons.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 178,494   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 2633   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA