Tetracaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2033   Edition : 37,

  ►   Brandname : Ametop,Anethaine,Pontocaine

  ►  Strength : Injection with 0.2  %, Injection with 0.3  %, Injection with 1  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : parentral, Topical,
Reference :-   Book : Martindale    Page : 2033   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia of the eye Topical 0.5 1 % Solution
2 Topical anaesthesia Topical 4 % Gel
3 Surface anaesthesia Transdermal 70 mg Transdermal Patch Dose: Given with 70 mg lidocaine.
4 Spinal block 0.5 % Injection

Ref :-  Book : Martindale    Page : 2033   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Topical anaesthesia <=5 Year Topical 5 gm Gel

Ref :- Book : Martindale    Page : 2033   Edition : 37,
►  Side Effect : cardiac arrest, hypotension, CNS depression, respiratory arrest , Contact dermatitis, keratoconjunctivities, urethral stricture,
Ref :-   Book : Martindale    Page : 2033   Edition : 37,

►  Drug Interaction : Drug interaction of Tetracaine is with Phenoxybenzamine , Doxofylline , Suxamethonium chloride,
Ref :-   Book : Martindale    Page : 2013,2033   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism of ester-type local anaesthetics may be inhibited by anticholinesterases, increasing the risk of systemic toxicity. Ester derivatives such as tetracaine, benzocaine, or procaine that are hydrolysed to para-aminobenzoic acid may antagonise the activity of aminosalicylic acid or sulfonamides. Ester-type local anaesthetics such as procaine and cocaine that are hydrolysed by plasma cholinesterase may competitively enhance the neuromuscular blocking activity of suxamethonium.,
Ref :-   Book : Martindale    Page : 2013-2033   Edition : 37,


►  Contraindication : Localized infection at proposed site of topical application,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 161   Edition : 3,
  ►  Mechanism of Action :   Tetracaine, a para-aminobenzoic acid ester, inhibit voltage-gated sodium channels in excitable call membrane. ,
Ref :-   Book : Martindale    Page : 2013   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 2033   Edition : 37,


►    Plasma Half-life :
  Min value :-   1.25,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA