Tetracaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2033   Edition : 37,

  ►   Brandname : Ametop,Anethaine,Pontocaine,Cepacol Viractin Cold Sore Treatment

  ►  Strength : Injection with 1  %, Ointment with 1  %, Ophthalmic Solution with 0.5  %, Cream with 1  %, Cream with 2  %, Solution with 2  %, Gel with 2  %, Eye Drop with   , Topical Aerosol with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12, Martindale    Page : 463   Edition : 12, Martindale    Page : 2033   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : parentral, Topical, ophthalmic,
Reference :-   Book : Martindale    Page : 2033   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia of the eye Topical 0.5 1 % Solution Ointments have also been used. Instillation of a 0.5% solution produces anaesthesia within 25 seconds that lasts for 15 minutes or longer and is suitable for use before minor surgical procedures
2 Topical anaesthesia Topical 4 % Gel Gel is used as a percutaneous local anaesthetic before venepuncture or venous cannulation.
3 Surface anaesthesia Transdermal 70 mg Transdermal Patch Dose: Given with 70 mg lidocaine 70 mg is available for surface anaesthesia of intact skin in connection with needle puncture and in cases of superficial surgical procedures.
4 Spinal block 0.5 % Injection

Ref :-  Book : Martindale    Page : 2033   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Topical anaesthesia 5Year Topical 5 gm Gel

Ref :- Book : Martindale    Page : 2033   Edition : 37,
►  Side Effect : Restlessness, excitement, Nervousness, paraesthesia, Dizziness, tinnitus, Blurred Vision, nausea, vomiting, muscle twitching, tremor, Convulsions, Numbness of the tongue and perioral region, lightheadedness, Depression, drowsiness, respiratory failure, coma, hypotension, bradycardia, Arrhythmias, cardiac arrest, A stinging sensation may occur when tetracaine is used in the eye, Mild erythema at the site of application is frequently seen with topical use; slight oedema or pruritus occur less commonly, Blistering of the skin may occur., ,
Ref :-   Book : Martindale    Page : 2011,2033   Edition : 37,

►  Drug Interaction : Drug interaction of Tetracaine is with Aminosalicylic Acid, Sulfonamides , ,  NA

  ►    Mechanism of Drug Drug Interaction :  Ester derivatives such as tetracaine, benzocaine, or procaine that are hydrolysed to para-aminobenzoic acid may antagonise the activity of aminosalicylic acid or sulfonamides. If local anaesthetics containing adrenaline are given for epidural or paracervical block during labour the use of an oxytocic drug post partum may lead to severe hypertension.,
Ref :-   Book : Martindale    Page : 2013,2033   Edition : 37,


►  Contraindication : Tetracaine should not be applied to inflamed, traumatised, or highly vascular surfaces. It should not be used to provide anaesthesia for bronchoscopy or cystoscopy, as lidocaine is a safer alternative.,
Ref :-   Book : Martindale    Page : 2033   Edition : 37,
  ►  Mechanism of Action :   Tetracaine, a para-aminobenzoic acid ester, inhibit voltage-gated sodium channels in excitable call membrane. It act by preventing the generation and transmission of impulses along nerve fibres and at nerve endings; depolarisation and ion-exchange are inhibited.,
Ref :-   Book : Martindale    Page : 2013,2033   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 2013,2033   Edition : 37,


►    Plasma Half-life :
  Min value :-   75 minutes,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2033   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA