Tetracycline is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 380   Edition : 37,

  ►   Brandname : Latycin, Tetrex, Achromycin, Imex, Topicycline, Sumycin, Tetrex

  ►  Strength : Capsule with 250  mg, Capsule with 500  mg, Suspension with 125/5  mg/ml, Ointment with 3  %, Topical solution with 0.2  %, Eye ointment with 1  %, Tablet with   , Injection with   , ophthalmic suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12, Martindale    Page : 379-380   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV, IM,
Reference :-   Book : Martindale    Page : 379   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Systemic infections Oral 250 500 mg Capsule Dose: Given every 6 hours, preferably 1 hour before or 2 hours after meals.
2 Acne Topical 3 % Ointment
3 Acne Topical 0.2 % Solution
4 Ocular infection Topical 1 % Eye ointment
5 Ocular infection Topical 1 % Eye Drop

Ref :-  Book : Martindale    Page : 379   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Systemic infections 12Year

Ref :- Book : Martindale    Page : 379   Edition : 37,
Precaution :- If a Patient is using 'Tetracycline' drug in  Urinary infection   disease, then Please Contraindication : In pregnancy. .

Precaution :- If a Patient is using 'Tetracycline' drug in  ACUTE VIRAL HEPATITIS  disease, then Please should be avoided .

►  Side Effect : nausea, vomiting, diarrhoea, oesophageal ulceration, glossitis, stomatitis, dysphagia, oral candidiasis, vulvovaginitis, pruritus, enterocolitis, Renal dysfunction, increases in liver enzymes, fatal hepatotoxicity, Pancreatitis, Permanent discoloration and enamel hypoplasia, Darkening effect of tetracyclines on permanent teeth appears to be related to the total dose given, nail discoloration, Onycholysis, Permanent discoloration of the cornea has been reported in infants born to mothers given tetracycline in high doses during pregnancy, intracranial hypertension, headache, Dizziness, tinnitus, visual disturbances, papilloedema, increased muscle weakness, hypersensitivity reactions, Rashes, fixed drug eruptions, exfoliative dermatitis, toxic epidermal necrolysis, drug fever, pericarditis, angioedema, Urticaria, asthma, photosensitivity, Local pain and irritation can occur when tetracyclines are given parenterally and thrombophlebitis may follow intravenous injections. A Jarisch-Herxheimer reaction occurs commonly in patients with relapsing fever treated with tetracyclines, hypoprothrombinaemia, ,
Ref :-   Book : Martindale    Page : 377   Edition : 37,

►  Drug Interaction : Drug interaction of Tetracycline is with , Antacids, , Diuretics, , , oral contraceptives,  Methoxyflurane, Digoxin , Halofantrine, Theophylline ,
Ref :-   Book : Martindale    Page : 378   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The absorption of the tetracyclines is reduced by divalent and trivalent cations such as aluminium, bismuth, calcium, iron, magnesium, and zinc, and therefore use of tetracyclines with antacids, iron preparations, some foods such as milk and dairy products, or other preparations containing such cations, whether as active ingredients or excipients, may result in subtherapeutic serum concentrations of the antibacterial. The nephrotoxic effects of tetracyclines may be exacerbated by diuretics, methoxyflurane, or other potentially nephrotoxic drugs. Potentially hepatotoxic drugs should be used with caution in patients receiving tetracyclines. An increased incidence of benign intracranial hypertension has been reported when retinoids and tetracyclines are given together; such use should be avoided. Tetracyclines have been reported to produce increased concentrations of lithium, digoxin, halofantrine, and theophylline (although these interactions are not strongly established); the effects of oral anticoagulants have also been increased in a few patients. Tetracyclines may decrease the effectiveness of oral contraceptives. Because of possible antagonism of the action of the penicillins by the mainly bacteriostatic tetracyclines it has been recommended that the two types of drug should not be used together, especially when a rapid bactericidal action is necessary.,
Ref :-   Book : Martindale    Page : 378   Edition : 37,


►  Contraindication : Hypersensitivity, Pregnancy, renal impairment, hepatic impairment, Patients who may be exposed to direct sunlight should be warned of the risk of photosensitivity. Care is advisable in patients with myasthenia gravis, who may be at risk of neuromuscular blockade. Tetracyclines should be avoided in those with SLE.,
Ref :-   Book : Martindale    Page : 378   Edition : 37,
  ►  Mechanism of Action :   Tetracyclines are broad-spectrum bacteriostatic antibiotics that inhibit protein synthesis. Tetracyclines enter microorganisms in part by passive diffusion and in part by an energy-dependent process of active transport. Susceptible organisms concentrate the drug intracellularly. Once inside the cell, tetracyclines bind reversibly to the 30S subunit of the bacterial ribosome, blocking the binding of aminoacyl-tRNA to the acceptor site on the m RNA ribosome complex . This prevents addition of amino acids to the growing peptide. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 810   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Neem oil with Another pathway, Acacia nilotica i.e. babool with Another pathway,

  ►  Pathway with its reference as follows :-
  • Nimbidin hane antibiotic effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • Avicin have Anti-bacterial --- ( Alavijeh, P. (2012). A study of antimicrobial activity of few medicinal herb . Asian Journal Of Plant Science And Research,, 2(4). )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152, http://pelagiaresearchlibrary.com/asian-journal-of-plant-science/vol2-iss4/AJPSR-2012-2-4-496-502.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Dietary Substance is Drug Inhibitor, IRON with Dietary Substance is Drug Inhibitor, MAGNESIUM with Dietary Substance is Drug Inhibitor, ZINC with Dietary Substance is Drug Inhibitor, GLUCOSAMINE with Dietary Substance is Drug Enhancer, VITAMIN C with Decrease in Nutrient Level,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealan
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://ajpcr.com/Vol2Issue4/226.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Reduces endogenous vitamin production by colonoic bacteria., with Reduces endogenous vitamin production by colonoic bacteria., ZINC with Increases urinary excretion., MAGNESIUM with Reduces both mineral & tetracycline absorption., MILK with Bind with calcium forming insoluble chelate take one hour before or two hour after meal., IRON with Bind with iron forming insoluble chelate take one hour before or two hour after meal., DAIRY FOOD with Dairy food decreases drug effectiveness.,

      ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • "Introduction Food, Dietary Supplements And Their Components Can .". European Journal o f Clinical Pharmacology, n. pag. Print.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://ajpcr.com/Vol2Issue4/226.pdf, http://shodhganga.inflibnet.ac.in/bitstream/10603/42594/5/05_chapter%201.pdf,

    ►   Route of Elimination :   Biliary, Renal, Faecal,
    Ref :-   Book : Martindale    Page : 379   Edition : 37,


    ►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 379   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 378   Edition : 37,