Tetracycline is a Medicine belongs to Chemotherapeutic drugs/ bacteriostatic antibiotics group whose information about Brand can be referenced from   Book : Martindale    Page : 380   Edition : 37,

  ►   Brandname : Achromycin,Hostacycline,Resteclin,Subamycin,Tetrabact,Topicycline,Bristacycline,Sumycin

  ►  Strength : Capsule with 250  mg, Capsule with 500  mg, Suspension with 125/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV, IM,
Reference :-   Book : Martindale    Page : 379   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial Oral 250 500 mg Dose: Given every 6 hours
2 Acne Topical 3 % Ointment
3 Acne Topical 0.2 % Solution
4 Ocular infection Topical 1 % Ointment
5 Ocular infection Topical 1 % drops

Ref :-  Book : Martindale    Page : 379   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antibacterial <=12 Year Oral 2 gm
2 Antibacterial <8 Year Oral 25 50 mg/kg

Ref :- Book : Martindale    Page : 379   Edition : 37,
►  Organ Affected Liver Disease – Hepatotoxic  

Precaution :- If a Patient is using 'Tetracycline' drug in  Urinary infection   disease, then Please Contraindication : In pregnancy. .

Precaution :- If a Patient is using 'Tetracycline' drug in  ACUTE VIRAL HEPATITIS  disease, then Please should be avoided .

►  Side Effect : nausea, vomiting, diarrhea, oesophageal ulceration, glossitis, stomatitis, dysphagia, oral candidiasis, vulvovaginitis, pruritus, diarrhoea, enterocolitis, Renal dysfunction, increases in liver enzymes, fatal hepatotoxicity, nail discoloration, Onycholysis, permanent discoloration of the cornea, intracranial hypertension with headache, Dizziness, tinnitus, visual disturbances, papilloedema, increased muscle weakness, myasthenia gravis, exacerbation of SLE, hypersenstivity, Rashes, fixed drug eruptions, exfoliative dermatitis, toxic epidermal necrolysis, drug fever, pericarditis, angioedema, Urticaria, asthma, photosensitivity, Acute renal failure, interstitial nephritis, Abnormal pigmentation of the skin, conjunctiva, oral mucosa, anaphylaxis, agranulocytosis, aplastic anaemia, haemolytic anaemia, eosinophilia, neutropenia, thrombocytopenia,
Ref :-   Book : Martindale    Page : 377   Edition : 37,

►  Drug Interaction : Drug interaction of Tetracycline is with Sodium bicarbonate , Colestipol , Cholestyramine , kaolin pectin,
Ref :-   Book : Martindale    Page : 378   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The absorption of the tetracyclines is reduced by divalent and trivalent cations such as aluminium, bismuth, calcium, iron, magnesium, and zinc, and therefore use of tetracyclines with antacids, iron preparations, some foods such as milk and dairy products, or other preparations containing such cations, whether as active ingredients or excipients, may result in subtherapeutic serum concentrations of the antibacterial. ,
Ref :-   Book : Martindale    Page : 378   Edition : 37,


►  Absolute Contraindication : Patients hypersensitive to any of this group of antibacterials   in pregnancy   breast feeding   infants and children up to the age of 8   and SLE patients   renal impairment.  

►  Contraindication : Hypersensitivity, pregnancy, Breast feeding, renal impairment, myasthenia gravis,
Ref :-   Book : Martindale    Page : 378   Edition : 37,
  ►  Mechanism of Action :   Tetracyclines are broad-spectrum bacteriostatic antibiotics that inhibit protein synthesis. Tetracyclines enter microorganisms in part by passive diffusion and in part by an energy-dependent process of active transport. Susceptible organisms concentrate the drug intracellularly. Once inside the cell, tetracyclines bind reversibly to the 30S subunit of the bacterial ribosome, blocking the binding of aminoacyl-tRNA to the acceptor site on the m RNA ribosome complex . This prevents addition of amino acids to the growing peptide. Ref 4 pg no 810. ed 12.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 810   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Neem oil with Another pathway, Acacia nilotica i.e. babool with Another pathway,

  ►  Pathway with its reference as follows :-
  • Nimbidin hane antibiotic effect --- (Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )
  • Avicin have Anti-bacterial --- ( Alavijeh, P. (2012). A study of antimicrobial activity of few medicinal herb . Asian Journal Of Plant Science And Research,, 2(4). )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152, http://pelagiaresearchlibrary.com/asian-journal-of-plant-science/vol2-iss4/AJPSR-2012-2-4-496-502.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CALCIUM with Dietary Substance is Drug Inhibitor, IRON with Dietary Substance is Drug Inhibitor, MAGNESIUM with Dietary Substance is Drug Inhibitor, ZINC with Dietary Substance is Drug Inhibitor, GLUCOSAMINE with Dietary Substance is Drug Enhancer, VITAMIN C with Decrease in Nutrient Level,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealan
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, http://ajpcr.com/Vol2Issue4/226.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Reduces endogenous vitamin production by colonoic bacteria., with Reduces endogenous vitamin production by colonoic bacteria., ZINC with Increases urinary excretion., MAGNESIUM with Reduces both mineral & tetracycline absorption., MILK with Bind with calcium forming insoluble chelate take one hour before or two hour after meal., IRON with Bind with iron forming insoluble chelate take one hour before or two hour after meal., DAIRY FOOD with Dairy food decreases drug effectiveness.,

      ►  Reference :-
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • YAHEYA, MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.
  • "Introduction Food, Dietary Supplements And Their Components Can .". European Journal o f Clinical Pharmacology, n. pag. Print.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://ajpcr.com/Vol2Issue4/226.pdf, http://shodhganga.inflibnet.ac.in/bitstream/10603/42594/5/05_chapter%201.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 378   Edition : 37,


    ►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 378   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 378   Edition : 37,