Tetrahydrobiopterin hcl/Sapropterin hcl is a Medicine belongs to Miscellaneous Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2618   Edition : 37  

  ►   Brandname : Kuvan
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 2618   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Phenylketonuria Oral 10 mg/kg In patients 4 years of age and above, usual maintenance daily doses are 5 to 20 mg/kg.
2 Tetrahydrobiopterin deficiency Oral 2 5 mg/kg In patients 4 year of age and above: dose adjusted up to 20 mg/kg daily as required; it may be necessary to distribute the dose over the day as 2 or 3 divided doses.

Ref :-  Book : Martindale    Page : 2618   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect :
Ref :-   Book :    Page :    Edition : .  

►  Drug Interaction : Drug interaction of Tetrahydrobiopterin hcl/Sapropterin hcl is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : NA
  ►  Mechanism of Action :   N.F.R.B
Ref :-   Book :    Page :    Edition : .  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fish with Another pathway.   Soya with Another pathway.   Protein with Another pathway.  

  ►  Pathway with its reference as follows :-
  • tyrosine is beneficial in pku --- ( Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart )
  • tyrosine is beneficial in pku --- ( Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )
  • tyrosine is beneficial in pku --- ( LINES, D., MAGAREY, A., RAYMOND, J., & ROBERTSON, E. (1997). TYROSINE SUPPLEMENTATION IN PHENYLKETONURIA. Journal Of Paediatrics And Child Health, 33(2), 177-177. )

  •   ►  URL --
  • http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf .
  • http://www.ncbi.nlm.nih.gov/pubmed/20687067 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA