Tetrahydrobiopterin/Sapropterin is a Medicine belongs to Supplementary Drugs and Other Substances group whose information about Brand can be referenced from   Book : Martindale    Page : 2618   Edition : 37,

  ►   Brandname : Biopten

  ►  Strength : Tablet with 20  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2618   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2618   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Phenylketonuria Oral 10 mg/kg Tablet Daily.
2 Tetrahydrobiopterin (BH4) deficiency Oral 2 5 mg/kg Tablet Daily.

Ref :-  Book : Martindale    Page : 2618   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : headache, running or obstructed nose, diarrhea, vomiting,
Ref :-   Book : Martindale    Page : 2618   Edition : 37,

►  Drug Interaction : Drug interaction of Tetrahydrobiopterin/Sapropterin is with Methotrexate, Trimethoprim ,
Ref :-   Book : Martindale    Page : 2618.2   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : ,
Ref :-   Book :    Page :    Edition : ,
  ►  Mechanism of Action :   nf,
Ref :-   Book :    Page :    Edition : ,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fish with Another pathway, Soya with Another pathway, Protein with Another pathway,

  ►  Pathway with its reference as follows :-
  • tyrosine is beneficial in pku --- ( Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart )
  • tyrosine is beneficial in pku --- ( Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart. )
  • tyrosine is beneficial in pku --- ( LINES, D., MAGAREY, A., RAYMOND, J., & ROBERTSON, E. (1997). TYROSINE SUPPLEMENTATION IN PHENYLKETONURIA. Journal Of Paediatrics And Child Health, 33(2), 177-177. )

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf, http://www.ncbi.nlm.nih.gov/pubmed/20687067,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA