Thiabendazole is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 165   Edition : 37,

  ►   Brandname : Mintezol

  ►  Strength : Tablet with 500  mg, Suspension with 500  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 165   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cutaneous larva migrans Oral 25 mg/kg b.d.
2 Dracunculiasis Oral 25 50 mg/kg b.d.
3 Trichinosis Oral 25 mg/kg b.d.
4 Strongyloidiasis Oral 25 mg/kg b.d.

Ref :-  Book : Martindale    Page : 165   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Dizziness, gastrointestinal disturbance, anorexia, nausea, vomiting, diarrhea, abdominal pain, pruritus, Skin rashes, headache, fatigue, drowsiness, drying of mucous membranes, Hyperglycaemia, disturbances of vision, leucopenia, tinnitus, cholestasis, Crystalluria, bradycardia, hypotension, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, convulsion, fever, chills, angioedema, lymphadenopathy,
Ref :-   Book : Martindale    Page : 165   Edition : 37,

►  Drug Interaction : Drug interaction of Thiabendazole is with Theophylline , Aminophylline ,
Ref :-   Book : Martindale    Page : 165   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Tiabendazole has been reported to increase serum-theophylline concentrations and to decrease theophylline clearance. It has been recommended that theophylline dosage should be reduced by 50% when tiabendazole therapy is started,
Ref :-   Book : Martindale    Page : 165   Edition : 37,


►  Contraindication : pregnancy, hepatic disease, renal disease, drowsiness, not drive,
Ref :-   Book : Martindale    Page : 165   Edition : 37,
  ►  Mechanism of Action :   The primary mechanism of action is thought to be inhibition of microtubule polymerization by binding to -tubulin. The selective toxicity of this agent against helminths results from their higher affinity for parasite -tubulin than for the same target in higher eukaryotes. ,
Ref :-   Book : Goodman    Page : 1450   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- CINNAMON with Increased risk of hypoglycaemia, bleeding ,

  ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 165   Edition : 37,


    ►    Plasma Half-life :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 165   Edition : 37,