Thiabendazole is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 165   Edition : 37,

  ►   Brandname : Mintezol

  ►  Strength : Chewable tablets with 500  mg, Suspension with 500  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 165   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral 25 mg/kg It is is given orally, with meals, for 2 or more days, the duration depending on the type of infection; the daily dose should not exceed 3 g. For those unable to tolerate 2 doses daily, 25 mg/kg may be given after the largest meal on day 1 and repeated 24 hours later after a similar meal on day 2. For mass treatment, a single dose of 50 mg/kg after the evening meal is suggested although the incidence of adverse effects may be higher than with 2 doses of 25 mg/kg.
2 Cutaneous larva migrans 25 50 mg/kg b.d. Dose: Given daily for 2 days, repeated after 2 days if necessary; topical treatment with a 10 to 15% suspension intended for oral use has also been advocated as an alternative or adjunct to oral treatment.
3 Dracunculiasis 25 50 mg/kg b.d. Dose: for one day; in massive infection a further 50 mg/kg may be given after 5 to 8 days.
4 Strongyloidiasis 25 mg/kg b.d. Dose: for 2 or 3 days or 50 mg/kg as a single dose; when the infection is disseminated treatment for at least 5 days may be necessary.
5 Trichinosis 25 mg/kg b.d. Dose: for 2 to 4 successive days.
6 Toxocariasis Oral 25 mg/kg b.d. Dose: for 5 to 7 days.

Ref :-  Book : Martindale    Page : 165   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Parasitic infections

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1177   Edition : 19,
►  Side Effect : Dizziness, gastrointestinal disturbance, anorexia, nausea, vomiting, diarrhea, abdominal pain, pruritus, Skin rashes, headache, fatigue, drowsiness, drying of mucous membranes, Hyperglycaemia, disturbances of vision, leucopenia, tinnitus, cholestasis, Crystalluria, bradycardia, hypotension, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, convulsion, fever, chills, angioedema, lymphadenopathy, Enuresis, parenchymal damage (in some cases severe and irreversible), The urine of some patients taking tiabendazole may have a characteristic odour similar to that after eating asparagus; it is attributed to the presence of a tiabendazole metabolite.,
Ref :-   Book : Martindale    Page : 165   Edition : 37,

►  Drug Interaction : Drug interaction of Thiabendazole is with Theophylline ,
Ref :-   Book : Martindale    Page : 165,1260   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Tiabendazole has been reported to increase serum-theophylline concentrations and to decrease theophylline clearance. It has been recommended that theophylline dosage should be reduced by 50% when tiabendazole therapy is started,
Ref :-   Book : Martindale    Page : 165,1260   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment, Tiabendazole causes drowsiness in some patients and those affected should not drive or operate machinery., Tiabendazole should not be used in mixed worm infections involving Ascaris lumbricoides as it can cause these roundworms to migrate; live roundworms have emerged through the mouth or nose.,
Ref :-   Book : Martindale    Page : 165   Edition : 37,
  ►  Mechanism of Action :   Tiabendazole, a benzimidazole derivative, is an anthelmintic with activity against most nematode worms; activity against some larval stages and ova has also been demonstrated. The mode of action is not certain, but tiabendazole may inhibit the fumarate-reductase system of worms thereby interfering with their source of energy.,
Ref :-   Book : Martindale    Page : 165   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- CINNAMON with Increased risk of hypoglycaemia, bleeding ,

  ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 165   Edition : 37,


    ►    Plasma Half-life :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 165   Edition : 37,