Thiamazole (Methimazole) is a Medicine belongs to Antithyroid agent group whose information about Brand can be referenced from   Book : Martindale    Page : 2377   Edition : 37,

  ►   Brandname : Northyz,Tapazole

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 695   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2377   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperthyroidism Oral 15 60 mg Tablet Dose: Given daily
2 Thyroid storm IV 80 240 mg Injection Dose: Given daily, ususally in 3 or 4 divided doses.

Ref :-  Book : Martindale    Page : 2377   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Thyroid storm Oral 400 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 2377   Edition : 37,
►  Side Effect : nausea, vomiting, gastric discomfort, headache, arthralgia, Skin rashes, pruritus, hair loss, bone marrow depression, mild leukopenia, fever, lupus-like syndrome, myopathy, vasculitis, nephritis, taste disturbances, granulocytosis, aplastic anaemia, thrombocytopenia,
Ref :-   Book : Martindale    Page : 2369   Edition : 37,

►  Drug Interaction : Drug interaction of Thiamazole (Methimazole) is with NA

  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : NA
  ►  Mechanism of Action :   Thiamazole is a thiourea antithyroid drug that acts by blocking the production of thyroid hormones through inhibition of thyroid peroxidase.,
Ref :-   Book : Martindale    Page : 2377,2365   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with same pathway,

  ►  Pathway with its reference as follows :-
  • Soybean having active constituent Genistein and daidzein from soy (Glycine max) inhibit thyroperoxidase that catalyses iodination and thyroid hormone biosynthesis . --- ( P.K.M, N., & Kumar Jha, D. (2013). Study on Antithyroid Property of Some Herbal Plants. International Journal Of Pharmaceutical Sciences Review And Research, 23(2), 203-211. )

  •   ►  URL -- http://globalresearchonline.net/journalcontents/v23-2/36.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MISTLETOE with Organ fibrosis and death, cardiotoxicity, bradycardia, hypovolaemic shock and CVD collapse, inflammatory reaction,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   6 hours,
    Ref :-   Book : Goodman    Page : 1146   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,