Thiamazole (Methimazole) is a Medicine belongs to Antithyroid agent group whose information about Brand can be referenced from   Book : Martindale    Page : 2377   Edition : 37, Martindale    Page : 2377   Edition : 37,

  ►   Brandname : Northyz,Tapazole,Favistan, Thyrozol

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 695   Edition : 12, Martindale    Page : 2377   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 2377   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperthyroidism Oral 15 60 mg Tablet Dose: Given daily. It is usually given in three divided doses but a single daily dose is also possible. Improvement is usually seen in 1 to 3 weeks and control of symptoms in 1 to 2 months. When the patient is euthyroid the dose is gradually reduced to a maintenance dose, usually 5 to 15 mg daily
2 Thyroid storm IV 80 240 mg Injection Dose: Given daily, ususally in 3 or 4 divided doses.

Ref :-  Book : Martindale    Page : 2377   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Thyroid storm Oral 400 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 2377   Edition : 37,
►  Side Effect : nausea, vomiting, gastric discomfort, headache, arthralgia, Skin rashes, pruritus, hair loss, bone marrow depression, mild leukopenia, fever, lupus-like syndrome, myopathy, vasculitis, nephritis, taste disturbances, ,
Ref :-   Book : Martindale    Page : 2367,2377   Edition : 37,

►  Drug Interaction : Drug interaction of Thiamazole (Methimazole) is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Thiourea antithyroid drugs may be used with care in breast-feeding mothers; neonatal development and thyroid function of the infant should be closely monitored and the lowest effective dose used. Propylthiouracil has been preferred to carbimazole or thiamazole since it enters breast milk less readily.,
Ref :-   Book : Martindale    Page : 2368,2377   Edition : 37,
  ►  Mechanism of Action :   Inhibit thyroid peroxidase reactions • block iodine organification • inhibit peripheral deiodination of T4 and T3 (primarily PTU),
Ref :-   Book : Basic & Clinical pharmacology    Page : 695   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Soyabean with same pathway,

  ►  Pathway with its reference as follows :-
  • Soybean having active constituent Genistein and daidzein from soy (Glycine max) inhibit thyroperoxidase that catalyses iodination and thyroid hormone biosynthesis . --- ( P.K.M, N., & Kumar Jha, D. (2013). Study on Antithyroid Property of Some Herbal Plants. International Journal Of Pharmaceutical Sciences Review And Research, 23(2), 203-211. )

  •   ►  URL -- http://globalresearchonline.net/journalcontents/v23-2/36.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MISTLETOE with Organ fibrosis and death, cardiotoxicity, bradycardia, hypovolaemic shock and CVD collapse, inflammatory reaction,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA