Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Antineoplastic	Oral	100	200	mg/m2	Tablet		Given daily, at various stages of treatment for short term cycles; similar doses have been used in children. A dose of 2 mg/kg daily increased after 4 weeks, if there is no response or toxicity allows, to 3 mg/kg daily may be given to adults and children in those rare cases when single agent therapy is considered appropriate.

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Antineoplastic	Oral	100	200	mg/m2	Tablet		Given daily, at various stages of treatment for short term cycles; similar doses have been used in children. A dose of 2 mg/kg daily increased after 4 weeks, if there is no response or toxicity allows, to 3 mg/kg daily may be given to adults and children in those rare cases when single agent therapy is considered appropriate.

Ref :-  Book : Martindale    Page : 860   Edition : 37  

Pediatric Dose

Ref :- Book : Martindale    Page : 860   Edition : 37  

►  Side Effect : Nausea, Vomiting, Adverse effects may be expected from most antineoplastics in tissues where normal cell division is fairly rapid, e.g. the bone marrow, lymphoreticular tissue, gastrointestinal mucosa, skin, and gonads, as well as in the fetus., Bone marrow depression, Profound suppression of normal immunity, Hyperuricaemia and acute renal failure due to uric acid nephropathy (the ‘tumour lysis syndrome’), leucopenia, Thrombocytopenia, Anaemia, Hypoplasia, Gastrointestinal disturbances, Hepatotoxicity, Cholestatic jaundice, Necrosis, Fever
Ref :-   Book : Martindale    Page : 691,816,860   Edition : 37.  
►  Drug Interaction : Drug interaction of Thioguanine is with Busulfan, Daunorubicin (Daunomycin)
Ref :-   Book : Martindale    Page : 860   Edition : 37.  

Drug interaction

Drug Interaction : Drug interaction of Thioguanine is with Busulfan, Daunorubicin (Daunomycin)

Book : Martindale    Page : 860   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Several cases of portal hypertension with hepatic nodular regenerative hyperplasia have been reported in patients who received thioguanine with busulfan. It has been suggested that daunorubicin might enhance the hepatotoxicity of thioguanine
Ref :-   Book : Martindale    Page : 860   Edition : 37.  

Mechanism of Drug

Mechanism of Drug Drug Interaction : Several cases of portal hypertension with hepatic nodular regenerative hyperplasia have been reported in patients who received thioguanine with busulfan. It has been suggested that daunorubicin might enhance the hepatotoxicity of thioguanine

Book : Martindale    Page : 860   Edition : 37.  

►  Contraindication : Thioguanine is potentially carcinogenic and mutagenic; an increased incidence of abortion has occurred in women given thioguanine during the first trimester of pregnancy, Thioguanine should be used with care in patients with impaired hepatic or renal function. Hepatic function should be monitored periodically, Where possible, immunosuppressant drugs should not be given to patients with acute infections, and dosage reduction or withdrawal should be considered if infection develops, until the infection has been controlled., Blood counts and measurement of haemoglobin concentrations should be carried out routinely to help predict the onset of bone-marrow depression. Great caution is needed when the marrow is already depressed from radiotherapy or therapy with other antineoplastics, and modification of dosage regimens may be required., Pregnancy should be avoided in women receiving them: in particular they should not be given, if possible, during the first trimester. Mothers receiving antineoplastic therapy should not breast feed., The use of antineoplastics in the elderly should take into consideration age-related physiological changes including decline in renal and hepatic function, reduced haematopoietic reserve, and reduced gastrointestinal and cardiac function.
Ref :-   Book : Martindale    Page : 697,816,860   Edition : 37.  

  ►  Mechanism of Action :   Tioguanine is an analogue of the naturally occurring purine, guanine. that acts as an antimetabolite. It is an analogue of the natural purines hypoxanthine and adenine. After the intracellular conversion of mercaptopurine to active nucleotides, including thioinosinic acid, it appears to exhibit a variety of actions including interfering with nucleic acid synthesis. It also has immunosuppressant properties. Its actions are specific for cells in S phase.
Ref :-   Book : Martindale    Page : 817,860   Edition : 37.  

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 860   Edition : 37.  
►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA