Thioguanine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 861   Edition : 37,

  ►   Brandname : Lanvis,Tabloid

  ►  Strength : Tablet with NF  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 860   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic Oral 100 200 mg/m2 Tablet Dose: Given daily

Ref :-  Book : Martindale    Page : 860   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : bone marrow depression, thrombocytopenia, granulocytopenia, anaemia, Crystalluria, haematuria, skin disorders, hyperpigmentation,
Ref :-   Book : Martindale    Page : 816   Edition : 37,

►  Drug Interaction : Drug interaction of Thioguanine is with Busulfan, Daunorubicin (Daunomycin),
Ref :-   Book : Martindale    Page : 860   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  A number of cases of portal hypertension with hepatic nodular regenerative hyperplasia have been reported in patients who received thioguanine with busulfan. It has been suggested that daunorubicin might enhance the hepatotoxicity of thioguanine ,
Ref :-   Book : Martindale    Page : 860   Edition : 37,


►  Contraindication : NA
  ►  Mechanism of Action :   Tioguanine is an analogue of the naturally occurring purine, guanine. that acts as an antimetabolite. It is an analogue of the natural purines hypoxanthine and adenine. After the intracellular conversion of mercaptopurine to active nucleotides, including thioinosinic acid, it appears to exhibit a variety of actions including interfering with nucleic acid synthesis. It also has immunosuppressant properties. Its actions are specific for cells in S phase.,
Ref :-   Book : Martindale    Page : 817   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MISTLETOE with Organ fibrosis and death, cardiotoxicity, bradycardia, hypovolaemic shock and CVD collapse, inflammatory reaction,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 860   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA