Thiopental Sodium is a Medicine belongs to Short acting barbiturate anaesthetic group whose information about Brand can be referenced from   Book : Martindale    Page : 1953   Edition : 37,

  ►   Brandname : Anesthal,Pentothal

  ►  Strength : Injection with 20  mg, Injection with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, rectal,
Reference :-   Book : Martindale    Page : 1952   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia IV 2.5 % Injection
2 Anaesthesia IV 250 mg Injection Dose: In pregnant patients
3 Reduce elevations of intracranial pressure 1.5 3 mg/kg Injection Dose: used as intermittent bolus injection.

Ref :-  Book : Martindale    Page : 1953   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Induction of anaesthesia slow i.v 2 7 mg/kg Injection
2 Status epilecticus >1 Day >28 Day Slow IV 2 mg/kg Injection
3 Status epilecticus 1 Month 18 Year slow i.v 4 mg/kg Injection
4 Status epilecticus IV 2.5 % Injection
5 Status epilecticus IV infusion 0.25 % Injection

Ref :- Book : Martindale    Page : 1953   Edition : 37,
►  Side Effect : coughing, hiccuping, sneezing, hypersensitivity reactions, muscle twitching, jerking, Cough, laryngospasm, bronchospasm, respiratory depression, thrombophlebitis, Tissue necrosis, shivering, drowsiness, Confusion, amnesia, headache, severe arterial spasm,
Ref :-   Book : Martindale    Page : 1952   Edition : 37,

►  Drug Interaction : Drug interaction of Thiopental Sodium is with Zonisamide , Phentolamine , Cyclizine , Ethinylestradiol , Nitrous oxide ,
Ref :-   Book : Martindale    Page : 1952   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Difficulty may be experienced in producing anaesthesia with the usual dose of barbiturate anaesthetics in patients accustomed to taking alcohol or other CNS depressants; additional anaesthetics may be necessary. Patients being treated with phenothiazine antipsychotics may experience increased hypotension. Some phenothiazines, especially promethazine, may also increase the incidence of excitatory phenomena produced by barbiturate anaesthetics; cyclizine may possibly have a similar effect. Opioid analgesics can potentiate the respiratory depressant effect of barbiturate anaesthetics and the dose of the anaesthetic may need to be reduced. Use with nitrous oxide greatly reduces the dose of barbiturate anaesthetics required for anaesthesia. Reduced doses of thiopental may be required in patients receiving sulfafurazole.,
Ref :-   Book : Martindale    Page : 1952   Edition : 37,


►  Contraindication : Dyspnoea, Respiratory obstruction, shock, dehydration, , severa anaemia, hyperkalemia, toxaemia, myasthenia gravis, myxoedema, muscular dystrophies, Cardiac disease,
Ref :-   Book : Martindale    Page : 1952   Edition : 37,
  ►  Mechanism of Action :   Enhance GABA activity at GABAA receptor. At high concentration, act as direct agonist at GABAA receptor. May also antagonize AMPA receptor. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 183   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1952   Edition : 37,


►    Plasma Half-life :
  Min value :-   10 hours,    Max value :-   12 hours,
Ref :-   Book : Martindale    Page : 1952   Edition : 37nf,

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA