Thiopental Sodium is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1953   Edition : 37  

  ►   Brandname : Anesthal, Pentothal
  ►  Strength : Injection with 20 mg/ml.  Injection with 25 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, rectal
Reference :-   Book : Martindale    Page : 1952   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anaesthesia IV 2.5 5 % Injection UK licensed product information states that a typical dose for inducing anaesthesia is 100 to 150 mg injected over 10 to 15 seconds, repeated after 30 to 60 seconds according to response. It also recommends that the total dosage used should not exceed 500 mg; in pregnant patients the total maximum dose is 250 mg. In some other countries, it is recommended that induction begin with a test dose of 25 to 75 mg; thereafter, a dose of 50 to 75 mg may be given at intervals of 20 to 40 seconds according to response. Once anaesthesia has been established, additional doses of 25 to 50 mg may be given as necessary. When thiopental is used as the sole anaesthetic, anaesthesia can be maintained by repeat doses as needed or by continuous intravenous infusion of a 0.2 or 0.4% solution.
2 Reduce elevations of intracranial pressure 1.5 3 mg/kg used as intermittent bolus injection.

Ref :-  Book : Martindale    Page : 1953   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Induction of anaesthesia slow i.v 2 7 mg/kg Injection
2 Status epilecticus Slow IV 2 mg/kg Injection
3 Status epilecticus 1 Month 18 Year slow i.v 4 mg/kg Injection
4 Status epilecticus IV 2.5 % Injection
5 Status epilecticus IV infusion 0.25 % Injection

Ref :- Book : Martindale    Page : 1953   Edition : 37  
►  Side Effect : Coughing, Hiccuping, Sneezing, Muscle twitching, Jerking, Thrombophlebitis, Tissue necrosis, Arterial spasm with burning pain, Prolonged blanching of the forearm and hand, Prolonged blanching of the forearm and hand and gangrene of digits, Hypersenstivity, Respiratory depression, Depress cardiac output, Fall in blood pressure, Arrhythmias, Postoperative vomiting, Shivering, Drowsiness, Confusion, Amnesia, Headache
Ref :-   Book : Martindale    Page : 1952   Edition : 37.  

►  Drug Interaction : Drug interaction of Thiopental Sodium is with Alcohol, , Phenothiazine antipsychotics, opioid analgesics,  Promethazine , Cyclizine , Nitrous oxide , Sulfafurazole
Ref :-   Book : Martindale    Page : 1952   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Producing anaesthesia with the usual dose of barbiturate anaesthetics in patients accustomed to taking alcohol or other CNS depressants; may be difficult additional anaesthetics may be necessary. Patients being treated with phenothiazine antipsychotics may experience increased hypotension. Some phenothiazines, especially promethazine, may also increase the incidence of excitatory phenomena produced by barbiturate anaesthetics; cyclizine may possibly have a similar effect. Opioid analgesics can potentiate the respiratory depressant effect of barbiturate anaesthetics and the dose of the anaesthetic may need to be reduced. Use with nitrous oxide greatly reduces the dose of barbiturate anaesthetics required for anaesthesia. Reduced doses of thiopental may be required in patients receiving sulfafurazole.
Ref :-   Book : Martindale    Page : 1952   Edition : 37.  

►  Contraindication : Barbiturate anaesthetics are contra-indicated when there is dyspnoea or respiratory obstruction such as in acute severe asthma or when maintenance of an airway cannot be guaranteed., Barbiturate anaesthetics should be used with caution in shock and dehydration, hypovolaemia, severe anaemia, hyperkalaemia, toxaemia, myasthenia gravis, myxoedema and other metabolic disorders, or in severe renal disease., Caution is also required in patients with cardiovascular disease, muscular dystrophies, adrenocortical insufficiency, or with increased intracranial pressure. Reduced doses are required in the elderly and in severe hepatic disease.
Ref :-   Book : Martindale    Page : 1952   Edition : 37.  
  ►  Mechanism of Action :   Enhance GABA activity at GABAA receptor. At high concentration, act as direct agonist at GABAA receptor. May also antagonize AMPA receptor.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 183   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism)
Ref :-   Book : Martindale    Page : 1952   Edition : 37.  

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA