Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Schizophrenia	Oral	50	100	mg	Tablet	t.i.d.	Dose: slowly titrated upwards to a maximum of 800 mg daily if necessary; doses should be reduced once effective control is achieved. The daily dosage range is 200 to 800 mg, which may be given in 2 to 4 divided doses. It has been recommended that increases in doses should be no more than 100 mg weekly.

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Schizophrenia	Oral	50	100	mg	Tablet	t.i.d.	Dose: slowly titrated upwards to a maximum of 800 mg daily if necessary; doses should be reduced once effective control is achieved. The daily dosage range is 200 to 800 mg, which may be given in 2 to 4 divided doses. It has been recommended that increases in doses should be no more than 100 mg weekly.

Ref :-  Book : Martindale    Page : 1139   Edition : 37  

Pediatric Dose

Ref :- Book :    Page :    Edition :   

►  Side Effect : Dry mouth, Constipation, Difficulty with micturition, Blurred Vision, Mydriasis, Tachycardia, ECG changes (particularly Q- and T-wave abnormalities), Hypotension (usually orthostatic), Delirium, Agitation, Hypersensitivity reactions, Urticaria, Exfoliative dermatitis, Erythema multiforme, Contact sensitivity, Photosensitivity reactions, Haemolytic anaemia, Aplastic anaemia, Thrombocytopenic purpura, Eosinophilia, Fatal agranulocytosis, Dystonia, Parkinson- like syndrome, Akathisia, Tardive dyskinesia, Perioral paresthesias, Neuroleptic malignant syndrome, Thioridazine has been associated with a higher incidence of antimuscarinic effects, but lower incidence of extrapyramidal effects than chlorpromazine, It may also be less sedating. However, it is more likely to induce hypotension and there is an increased risk of cardiotoxicity and dose-related prolongation of the QT interval., Because of this and the consequent danger of life-threatening arrhythmias such as torsade de pointes and sudden death, its use has been restricted., Sexual dysfunction also appears to be more frequent with thioridazine.
Ref :-   Book : Martindale    Page : 1072,1138   Edition : 37.  
►  Drug Interaction : Drug interaction of Thioridazine is with Antiarrhythmics, , Selective nonadrenaline reuptake inhibitors, , , Beta Blockers , Hiv Protease Inhibitors, Opioids, , Alcohol, General anaesthetics , Hypnotics, Anxiolytics, , Antimalarials, Diuretics,  Cisapride
Ref :-   Book : Martindale    Page : 1076,1138   Edition : 37.  

Drug interaction

Drug Interaction : Drug interaction of Thioridazine is with Antiarrhythmics, , Selective nonadrenaline reuptake inhibitors, , , Beta Blockers , Hiv Protease Inhibitors, Opioids, , Alcohol, General anaesthetics , Hypnotics, Anxiolytics, , Antimalarials, Diuretics,  Cisapride

Book : Martindale    Page : 1076,1138   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  The metabolism of thioridazine is mediated by the cytochrome P450 isoenzyme CYP2D6; thioridazine itself is also an inhibitor of CYP2D6. Therefore, there is the potential for interactions between thioridazine and other drugs that inhibit or act as a substrate for this enzyme; such drugs should not be given with thioridazine. Some examples include antiarrhythmics, certain antidepressants including the SSRIs and tricyclics, certain antipsychotics, beta blockers, HIV-protease inhibitors, and opioids. Use with other drugs known to prolong the QT interval such as class IA and class III antiarrhythmics, tricyclic antidepressants, and some other antipsychotics should also be avoided, as should use with those drugs known to cause electrolyte imbalance. Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, dosage adjustments may be necessary. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.
Ref :-   Book : Martindale    Page : 1076,1138   Edition : 37.  

Mechanism of Drug

Mechanism of Drug Drug Interaction : The metabolism of thioridazine is mediated by the cytochrome P450 isoenzyme CYP2D6; thioridazine itself is also an inhibitor of CYP2D6. Therefore, there is the potential for interactions between thioridazine and other drugs that inhibit or act as a substrate for this enzyme; such drugs should not be given with thioridazine. Some examples include antiarrhythmics, certain antidepressants including the SSRIs and tricyclics, certain antipsychotics, beta blockers, HIV-protease inhibitors, and opioids. Use with other drugs known to prolong the QT interval such as class IA and class III antiarrhythmics, tricyclic antidepressants, and some other antipsychotics should also be avoided, as should use with those drugs known to cause electrolyte imbalance. Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, dosage adjustments may be necessary. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.

Book : Martindale    Page : 1076,1138   Edition : 37.  

►  Contraindication : Pre-existing CNS depression or coma, Bone marrow suppression, Phaeochromocytoma, Prolactin-dependent tumours, Hepatic impairment, Renal impairment, Cardiovascular impairment, Cerebrovascular impairment, Respiratory function impairment, Angle-closure glaucoma, History of jaundice, Parkinsonism, Diabetes mellitus, Hypothyroidism, Myasthenia gravis, Paralytic ileus, prostatic hyperplasia, Urinary retention, Thioridazine should not be used in patients with clinically significant cardiac disorders, uncorrected hypokalaemia or other electrolyte imbalance, with known or suspected QT prolongation or a family history of QT prolongation, or with a history of ventricular arrhythmias including torsade de pointes., Use is also contra-indicated in patients known to have reduced activity of the cytochrome P450 isoenzyme CYP2D6, which is responsible for thioridazine metabolism. Use with drugs liable to interfere with the metabolism of thioridazine, with other drugs known to prolong the QT interval, and with drugs likely to cause electrolyte imbalance should also, Use is also contra-indicated in patients known to have reduced activity of the cytochrome P450 isoenzyme CYP2D6, which is responsible for thioridazine metabolism., Use with drugs liable to interfere with the metabolism of thioridazine, with other drugs known to prolong the QT interval, and with drugs likely to cause electrolyte imbalance should also be avoided.
Ref :-   Book : Martindale    Page : 1075,1138   Edition : 37.  

  ►  Mechanism of Action :   Antagonize mesolimbic, and possibly mesocortical, D2 receptors; adverse effects are likely mediated by binding to D2 receptors in basal ganglia (nigrostriatal pathway) and pituitary gland.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3.  

►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1078,1138   Edition : 37.  
►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   10 hours.  
Ref :-   Book : Martindale    Page : 1138   Edition : 37.  
►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .