Thioridazine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1139   Edition : 37,

  ►   Brandname : Mellaril,Thioril

  ►  Strength : Tablet with 10  mg, Tablet with 15  mg, Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg, Tablet with 150  mg, Tablet with 200  mg, Solution with 30  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1139   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 50 100 mg t.i.d.

Ref :-  Book : Martindale    Page : 1139   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : dry mouth, constipation, urinary retention, Orthostatic hypotension, failure to ejaculation, Sedation, Neuroleptic malignant syndrome, catatonia, fever, autonomic instability, Tardive dyskinesia, Involuntary Defaecation, facial musculature, arms, trunk, pigmentary retinopathy,
Ref :-   Book : Goodman    Page : 442   Edition : 12,

►  Drug Interaction : Drug interaction of Thioridazine is with Abatacept , , , Mivacurium Chloride , Pioglitazone Hydrochloride , Ethinylestradiol ,
Ref :-   Book : Martindale    Page : 1138   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The metabolism of thioridazine is mediated by the cytochrome P450 isoenzyme CYP2D6; thioridazine itself is also an inhibitor of CYP2D6. Therefore, there is the potential for interactions between thioridazine and other drugs that inhibit or act as a substrate for this enzyme; such drugs should not be given with thioridazine. Some examples include antiarrhythmics, certain antidepressants including the SSRIs and tricyclics, certain antipsychotics, beta blockers, HIV-protease inhibitors, and opioids. Use with other drugs known to prolong the QT interval such as class IA and class III antiarrhythmics, tricyclic antidepressants, and some other antipsychotics should also be avoided, as should use with those drugs known to cause electrolyte imbalance.,
Ref :-   Book : Martindale    Page : 1138   Edition : 37,


►  Contraindication : Myelosuppression, , Parkinson’s disease, prolonged QT interval ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3,
  ►  Mechanism of Action :   Antagonize mesolimbic, and possibly mesocortical, D2 receptors; adverse effects are likely mediated by binding to D2 receptors in basal ganglia (nigrostriatal pathway) and pituitary gland. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1138   Edition : 37,


    ►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   10 hours,
    Ref :-   Book : Martindale    Page : 1138   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,