Tiagabine is a Medicine belongs to Antiseizure drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 551   Edition : 37,

  ►   Brandname : Gabitril

  ►  Strength : Tablet with 2  mg, Tablet with 4  mg, Tablet with 12  mg, Tablet with 16  mg, Tablet with 20  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 550   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antiepileptic Oral 5 10 mg Solution Dose: Given as single dose or 2 divided doses.

Ref :-  Book : Martindale    Page : 550   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Nervousness, Dizziness, irritability, tremor, psychoses, difficulties in concentration, Depression, Tiredness, Somnolence, Confusion, nystagmus, Visual field defect, abdominal pain, diarrhea, nausea, ataxia, Bruising, Rashes, flu-like syndrome, chills, fever, Speech Difficulties, headache,
Ref :-   Book : Martindale    Page : 549   Edition : 37,

►  Drug Interaction : Drug interaction of Tiagabine is with Carbamazapine , Phenobarbital , Phenytoin , Primidone ,
Ref :-   Book : Martindale    Page : 550   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The hepatic metabolism of tiagabine is accelerated by antiepileptics that induce enzymes of the cytochrome P450 system,
Ref :-   Book : Martindale    Page : 549   Edition : 37,


►  Contraindication : non-epileptic patients, hepatic impairment,
Ref :-   Book : Martindale    Page : 550   Edition : 37,
  ►  Mechanism of Action :   It inhibits the uptake of GABA into neuronal and glial cells, and therefore increases the availability of GABA at receptor sites,
Ref :-   Book : Martindale    Page : 550   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Fecal,
Ref :-   Book : Martindale    Page : 550   Edition : 37,


►    Plasma Half-life :
  Min value :-   7 hours,    Max value :-   9 hours,
Ref :-   Book : Martindale    Page : 550   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,