Tiagabine is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 551   Edition : 37  

  ►   Brandname : Gabitril
  ►  Strength : Tablet with 2 mg.  Tablet with 4 mg.  Tablet with 12 mg.  Tablet with 16 mg.  Tablet with 20 mg.  Oral Suspension with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12   Martindale    Page : 551   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 550   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Treatment of epilepsy as adjunctive therapy for refractory partial seizures with or without secondary generalisation Oral 5-10 30-45 mg Oral Suspension Dose: Given as single dose or 2 divided doses, increased weekly as necessary by increments of 5 to 10 mg.

Ref :-  Book : Martindale    Page : 550   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antiepileptic Oral 0.5 2 mg/kg/day tid/tid/qid

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2030   Edition : 19  
►  Side Effect : Dizziness, Nervousness, Tiredness, Somnolence, Tremor, Irritability, Confusion, Depression, Psychosis, Difficulties in concentration, Diarrhoea, Abdominal pain, Nausea, Ataxia, Emotional lability, Nystagmus, Bruising, Rashes, Speech Difficulties, Flu-like syndrome, Chills, Fever, Myalgia, Headache
Ref :-   Book : Martindale    Page : 549   Edition : 37.  

►  Drug Interaction : Drug interaction of Tiagabine is with Carbamazapine , Phenobarbital , Phenytoin , Primidone
Ref :-   Book : Martindale    Page : 550   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. The hepatic metabolism of tiagabine is accelerated by antiepileptics that induce enzymes of the cytochrome P450 system such as carbamazepine, phenobarbital, phenytoin, or primidone. Plasma concentrations of tiagabine may be reduced up to threefold by use with these drugs.
Ref :-   Book : Martindale    Page : 550   Edition : 37.  


►  Contraindication : Non-epileptic patients, Hepatic impairment
Ref :-   Book : Martindale    Page : 550   Edition : 37.  
  ►  Mechanism of Action :   It inhibits the uptake of GABA into neuronal and glial cells, and therefore increases the availability of GABA at receptor sites
Ref :-   Book : Martindale    Page : 550   Edition : 37.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal, Fecal
Ref :-   Book : Martindale    Page : 550   Edition : 37.  

►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   9 hours.  
Ref :-   Book : Martindale    Page : 550   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .