Tibolone is a Medicine belongs to Sex harmones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2343   Edition : 37,

  ►   Brandname : Livial,Tibofem,Tibomax

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2343   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2343   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal HRT Oral 2.5 mg Tablet Dose: Given daily in a continuous regimen. Tibolone should not be started for at least 12 months after the last menstrual period of a natural menopause, but may be started immediately in women who have undergone a surgical menopause or who are being treated with a gonadorelin analogue.

Ref :-  Book : Martindale    Page : 2343   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition : ,
►  Side Effect : Irregular vaginal bleeding or spotting, leucorrhoea, pruritus, candidiasis, vaginitis, breast pain, weight gain, oedema, Dizziness, Skin reactions, headache, migraine, visual disturbances, gastrointestinal disturbance, hypertrichosis, altered liver function, Depression, arthralgia, myalgia,
Ref :-   Book : Martindale    Page : 2342   Edition : 37,

►  Drug Interaction : Drug interaction of Tibolone is with Phenytoin , Carbamazapine , Rifampicin , Warfarin ,
Ref :-   Book : Martindale    Page : 1570, 2343   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Compounds that induce liver enzymes, such as phenytoin, carbamazepine, and rifampicin, might theoretically enhance the metabolism of tibolone and thus reduce its activity. A retrospective study15 of women receiving anticoagulant therapy who were started on HRT found that tibolone enhanced the effect of warfarin and of phenindione, possibly due to its androgenic properties.,
Ref :-   Book : Martindale    Page : 1570, 2343   Edition : 37,


►  Contraindication : Tibolone is contra-indicated in women with hormonedependent tumours, cardiovascular or cerebrovascular disorders including thrombophlebitis, thromboembolic processes, or a history of these conditions, undiagnosed vaginal bleeding, untreated endometrial hyperplasia, porphyria, and severe liver disorders., It should not be given to pregnant women and is not intended for use in premenopausal women, except those being treated with a gonadorelin analogue.,
Ref :-   Book : Martindale    Page : 2343   Edition : 37,
  ►  Mechanism of Action :   Tibolone is a steroid derived from noretynodrel that has oestrogenic, progestogenic, and weak androgenic properties,
Ref :-   Book : Martindale    Page : 2343   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- ST JOHNS WORT with Cause liver damage when taken together .,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2343   Edition : 37,


    ►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2343   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   1.5 hour,
    Ref :-   Book : Martindale    Page : 2343   Edition : 37,