Tibolone is a Medicine belongs to Sex harmones and their modulators group whose information about Brand can be referenced from   Book : Martindale    Page : 2343   Edition : 37,

  ►   Brandname : Livial,Tibofem,Tibomax

  ►  Strength : Tablet with NF  ,

Reference of this Medicine for its Strength can be taken from   Book :    Page :    Edition : ,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2343   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Menopausal HRT Oral 2.5 mg Tablet Dose: Given daily in a continuous regimen. Tibolone should not be started for at least 12 months after the last menstrual period of a natural menopause, but may be started immediately in women who have undergone a surgical menopause or who are being treated with a gonadorelin analogue.

Ref :-  Book : Martindale    Page : 2343   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : irregular menstrual bleeding, leucorrhoea, pruritus, candidiasis, vaginitis, breast pain, weight gain, oedema, Dizziness, Skin reactions, headache, migraine, visual disturbances, gastrointestinal disturbance, hypertrichosis, altered liver function tests, Depression, arthralgia, myalgia,
Ref :-   Book : Martindale    Page : 2342   Edition : 37,

►  Drug Interaction : Drug interaction of Tibolone is with Phenytoin , Carbamazapine , Rifampicin ,
Ref :-   Book : Martindale    Page : 2343   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Compounds that induce liver enzymes, such as phenytoin, carbamazepine, and rifampicin, might theoretically enhance the metabolism of tibolone and thus reduce its activity,
Ref :-   Book : Martindale    Page : 2343   Edition : 37,


►  Contraindication : pregnant women, hormone dependent tumour, cardiovascular or cerebrovascular disorder, thrombophlebitis, thromboembolic processes, vaginal bleeding, endometrial hyperplasia, Porphyria, Liver disorder ,
Ref :-   Book : Martindale    Page : 2343   Edition : 37,
  ►  Mechanism of Action :   Tibolone is a steroid derived from noretynodrel that has oestrogenic, progestogenic, and weak androgenic properties,
Ref :-   Book : Martindale    Page : 2343   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- ST JOHNS WORT with Cause liver damage when taken together .,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2343   Edition : 37,


    ►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2343   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   1.5 hour,
    Ref :-   Book : Martindale    Page : 2343   Edition : 37,