Ticarcillin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 383   Edition : 37,

  ►   Brandname : Ticar

  ►  Strength : Injection with 1; 3; 6  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IM or Slow IV,
Reference :-   Book : Martindale    Page : 383   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gram-negative infections, especially those due to Pseudomonas aeruginosa, cystic fibrosis (respiratory-tract infections), immunocompromised patients (neutropenia), peritonitis, and septicaemia, bone and joint infections, meningitis, otitis media (chronic) skin infections (burns, ecthyma gangrenosum, ulceration), and urinary-tract infections. IV infusion 200 300 mg/kg Injection Given in divided doses every 4 or 6 hours.
2 Complicated urinary tract infection IV infusion 150 200 mg/kg Injection Dose: divided every 4 or 6 hours
3 Uncomplicated urinary-tract infections IM or Slow IV 1 gm Injection

Ref :-  Book : Martindale    Page : 383   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Infections caused by susceptible Gram-negative organisms i.v/i.m 75 mg/kg Injection
2 Infections caused by susceptible Gram-negative organisms i.v/i.m 75 mg/kg Injection
3 Infections caused by susceptible Gram-negative organisms i.v/i.m 100 mg/kg Injection
4 Infections caused by susceptible Gram-negative organisms 1 Month i.v/i.m 100 200 mg/kg Injection

Ref :- Book : Martindale    Page : 383   Edition : 37,
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Ticarcillin is with TETRACYCLINES , Anticoagulant ,  Probenecid , Amoxicillin , nafcillin, Benzylpenicillin , Chloramphenicol ,
Ref :-   Book : Martindale    Page : 232,382   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of ticarcillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Clinically significant reductions in renal clearance have also been noted for amoxicillin, nafcillin, and benzylpenicillin. Ticarcillin may also interact with bacteriostatic antibacterials such as chloramphenicol and tetracyclines, and may be incompatible in vitro with other drugs, including some other antibacterials. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like ampicillin should be borne in mind in patients receiving anticoagulants.,
Ref :-   Book : Martindale    Page : 232,382   Edition : 37,


►  Contraindication : renal impairment, hypersensitive to penicillins, history of allergy, Care is necessary if very high doses of ticarcillin are given, especially if renal function is poor, because of the risk of neurotoxicity., Renal, hepatic, and haematological status should be monitored during prolonged and high-dose therapy. Because of the Jarisch-Herxheimer reaction, care is also necessary when treating patients with spirochaete infections, particularly syphilis.,
Ref :-   Book : Martindale    Page : 232,235,282   Edition : 37,
  ►  Mechanism of Action :   Action of -lactam antibiotics in Staphylococcus aureus. The bacterial cell wall consists of glycopeptide polymers (a NAM-NAG amino-hexose backbone) linked via bridges between amino acid side chains. In S. aureus, the bridge is (Gly)5-D-Ala between lysines. The cross-linking is catalyzed by a transpeptidase, the enzyme that penicillins and cephalosporins inhibit. NAM, N-acetyl-muramic acid; NAG, N-acetyl-glucosamine,
Ref :-   Book : Goodman    Page : 1479   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Acacia nilotica i.e. babool with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Alavijeh, P. (2012). A study of antimicrobial activity of few medicinal herb . Asian Journal Of Plant Science And Research,, 2(4) )

  •   ►  URL -- http://pelagiaresearchlibrary.com/asian-journal-of-plant-science/vol2-iss4/AJPSR-2012-2-4-496-502.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 382   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   70 minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 382   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
    Ref :-   Book : Martindale    Page : 382   Edition : 37,