Ticarcillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 383   Edition : 38,

  ►   Brandname : Timentin

  ►  Strength : Injection with 3  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 378   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : NA

►  Drug Interaction : Drug interaction of Ticarcillin is with Probenecid , Tetracycline , Ropinirole , Vecuronium Bromide , Cyclosporine , Voglibose , Methotrexate,
Ref :-   Book : Martindale    Page : 232, 343, 1566   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of Ticarcillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like ticarcillin should be borne in mind in patients receiving anticoagulants. Antagonism has been reported to occur with some bacteriostatic drugs, such as chloramphenicol or tetracyclines, that interfere with active bacterial growth necessary for ticarcillin to achieve its effect. And both enhancement and antagonism of its activity have been demonstrated for beta-lactam combinations. It is reported to prolong the action of competitive muscle relaxants such as vecuronium. Ticarcillin as other penicillins may markedly decrease the clearance of methotrexate given intravenously for treatment of neoplasms. Ticarcillin may be responsible like ampicillin to decrease oral contraceptive efficacy. Some studies have pointed to interference with intestinal flora involved in enterohepatic circulation of oestrogens as being a likely mechanism for this interaction. ,
Ref :-   Book : Martindale    Page : 232,343,1566   Edition : 37,


►  Contraindication : Hypersensitivity, Allergy, renal impairment, hepatic impairment,
Ref :-   Book : Martindale    Page : 232,235   Edition : 38,
  ►  Mechanism of Action :   Ticarcillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Ticarcillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. Clavulanic acid is a potent progressive inhibitor of plasmid-mediated and some chromosomal beta-lactamases produced by Gram-negative bacteria and some Enterobacteriaceae. It is also an inhibitor of the beta-lactamases produced by Staphylococcus aureus. ,
Ref :-   Book : Martindale    Page : 268   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Acacia nilotica i.e. babool with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Alavijeh, P. (2012). A study of antimicrobial activity of few medicinal herb . Asian Journal Of Plant Science And Research,, 2(4) )

  •   ►  URL -- http://pelagiaresearchlibrary.com/asian-journal-of-plant-science/vol2-iss4/AJPSR-2012-2-4-496-502.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 382   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA