Ticlopidine is a Medicine belongs to Antiandrogen group whose information about Brand can be referenced from   Book : Martindale    Page : 1550   Edition : 37,

  ►   Brandname : Ticlobest,Ticlop,Ticlopid,Ticlid

  ►  Strength : Tablet with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Stroke Oral 250 mg Tablet b.d.
2 Intermittent claudication Oral 250 mg Tablet b.d.
3 Intracoronary stenting Oral 250 mg Tablet b.d. Dose: Given daily for 4 weeks, starting at the time of stent placement.

Ref :-  Book : Martindale    Page : 1549   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Organ Affected Nephrotoxicity – (Thromobotic microangiopathy)  

►  Side Effect : bleeding, gastrointestinal disturbance, Skin rashes, aplastic anaemia, neutropenia, thrombotic thrombocytopenic purpura, cholestatic jaundice, hepatitis,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,

►  Drug Interaction : Drug interaction of Ticlopidine is with Ropinirole , Liothyronine Sodium (T3) , Cimetidine , Corticosteroids,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Ticlopidine should be used with caution in patients receiving other drugs, such as anticoagulants and antiplatelets, that increase the risk of bleeding. Ticlopidine is an inhibitor of cytochrome P450, including the isoenzymes CYP2C19, CYP2D6, and CYP2B6, and may inhibit the metabolism of other drugs that are metabolised by this route. The clearance of ticlopidine may be reduced by cimetidine. Corticosteroids may antagonise the effect of ticlopidine on bleeding time.,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,


►  Absolute Contraindication : Neutropenia or thrombocytopenia   haemorrhagic diathesis or other haemorrhagic disorders associated with a prolonged bleeding time   or conditions with an increased risk of bleeding such as peptic ulcer disease   acute cerebral haemorrhage   or severe liver dysfunction.  

►  Contraindication : neutropenia, thrombocytopenia, Haemorrhagic disorder, peptic ulcer disease, cerebral haemorrhage, severe liver dysfunction,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,
  ►  Mechanism of Action :   Covalently modify platelet ADP receptor, thereby preventing receptor signaling and irreversibly inhibiting ADP-dependent platelet activation pathway,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 395   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,


►    Plasma Half-life :
  Min value :-   30 hours,    Max value :-   50 hours,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,