Ticlopidine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1550   Edition : 37, Martindale    Page : 1550   Edition : 37,

  ►   Brandname : Ticlobest,Ticlop,Ticlopid,Ticlid,Desiticlopidin, Tiklyd, Tilodene

  ►  Strength : Tablet with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prevention of thrombotic stroke, and in intermittent claudication Oral 250 Mg Tablet b.d. Dose: Given with meals.
2 Prevention of subacute stent occlusion after intracoronary stenting Oral 250 Mg Tablet b.d. Dose: Given daily for 4 weeks, starting at the time of stent placement.

Ref :-  Book : Martindale    Page : 1550   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition : ,
►  Side Effect : bleeding, Skin rashes, Gastrointestinal disturbances, blood dyscrasias, neutropenia, thrombotic thrombocytopenic purpura, aplastic anaemia, hepatitis, cholestatic jaundice,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,

►  Drug Interaction : Drug interaction of Ticlopidine is with Cimetidine , Corticosteroids,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Ticlopidine should be used with caution in patients receiving other drugs, such as anticoagulants and antiplatelets, that increase the risk of bleeding. Ticlopidine is an inhibitor of cytochrome P450, including the isoenzymes CYP2C19, CYP2D6, and CYP2B6, and may inhibit the metabolism of other drugs that are metabolised by this route. The clearance of ticlopidine may be reduced by cimetidine. Corticosteroids may antagonise the effect of ticlopidine on bleeding time.,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,


►  Contraindication : Active bleeding disorder, neutropenia, thrombocytopenia, severe liver dysfunction,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 395   Edition : 37,
  ►  Mechanism of Action :   Covalently modify platelet ADP receptor, thereby preventing receptor signaling and irreversibly inhibiting ADP-dependent platelet activation pathway,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 395   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,


►    Plasma Half-life :
  Min value :-   30 hours,    Max value :-   50 hours,
Ref :-   Book : Martindale    Page : 1549   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,