Tigecycline is a Medicine belongs to Chemotherapeutic Drugs/ Tetracyclines group whose information about Brand can be referenced from   Book : Martindale    Page : 379   Edition : 38,

  ►   Brandname : Tygacil

  ►  Strength : Injection with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 379   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial IV infusion 100 mg Injection

Ref :-  Book : Martindale    Page : 379   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, diarrhea, abdominal pain, abscess, anorexia, dyspepsia, Dizziness, headache, phlebitis, pruritus, rash, sepsis, septic shock, raised liver enzyme values, bilirubinaemia, increased serum amylase, increased blood urea nitrogen, thrombocythaemia, anaemia, leucocytosis, acute pancreatitis, life-threatening anaphylaxis, Anaphylactoid reactions,
Ref :-   Book : Martindale    Page : 379   Edition : 38,

►  Drug Interaction : Drug interaction of Tigecycline is with Cyclosporine ,
Ref :-   Book : Martindale    Page : 379   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Increased serum concentrations of ciclosporin associated with concomitant tigecycline treatment,
Ref :-   Book : Martindale    Page : 379   Edition : 38,


►  Contraindication : pregnancy, during tooth development (up to 8 years of age),
Ref :-   Book : Martindale    Page : 379   Edition : 37,
  ►  Mechanism of Action :   Bind to 16S rRNA of the 30S ribosomal subunit and inhibit protein synthesis by blocking the binding of aminoacyl tRNA to the A site on the mRNA-ribosome complex,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 591   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Renal,
Ref :-   Book : Martindale    Page : 379   Edition : `38,


►    Plasma Half-life :
  Min value :-   42 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 379   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   nf,
Ref :-   Book :    Page :    Edition : ,