Tinidazole is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Martindale    Page : 937   Edition : 37   Martindale    Page : 937   Edition : 37      Page :   Edition :   

  ►   Brandname : Enidazol, Tiniba, Fasigyn, Tindamax, Ciplox-TZ, H-P kit, Simplotan, Fasigyn, Simplotan
  ►  Strength : Tablet with .  Injection with .  Vaginal Pessaries with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 937   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion
Reference :-   Book : Martindale    Page : 937   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Intestinal amoebiasis Oral 2 gm Tablet Dose: Given for 2 or 3 days.
2 Hepatic amoebiasis Oral 1.5 2 gm Tablet Dose: Given as a single daily dose may be given for 3 days or occasionally up to 6 days.
3 Giardiasis Oral 2 gm Tablet o.d.
4 Trichomoniasis Oral 2 gm o.d.
5 Ulcerative gingivitis Oral 2 gm o.d.
6 Bacterial vaginosis Oral 2 gm Tablet Although higher cure rates have been achieved with a 2-g dose on 2 successive days or 1 g daily for 5 days.
7 Anaerobic bacterial infections Oral 2 gm Tablet Dose: followed on subsequent days by 1 g daily or 500 mg twice daily.
8 Anaerobic bacterial infections IV infusion 800 mg Injection Dose: 800 mg being infused as 400 mL of a 2 mg/mL solution at a rate of 10 mL/minute; this initial dose is followed by 800 mg daily or 400 mg twice daily until oral therapy can be substituted.
9 Prevention of postoperative anaerobic bacterial infections Oral 2 gm Tablet Dose: About 12 hours before surgery. Alternatively 1.6 g is given as a single intravenous infusion before surgery.
10 Peptic ulcer disease 500 mg Dose: given with clarithromycin and omeprazole for 7 days.

Ref :-  Book : Martindale    Page : 937   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Intestinal or hepatic amoebiasis Oral 50 60 mg/kg Tablet
2 Giardiasis or trichomoniasis Oral 50 75 mg/kg Tablet

Ref :- Book : Martindale    Page : 937   Edition : 37  
►  Side Effect : Gastrointestinal disturbances, Nausea, Unpleasant metallic taste, Abdominal pain, Anorexia, Vomiting, Diarrhoea, Constipation, Furred tongue, Glossitis, Stomatitis, Weakness, Dizziness, Ataxia, Headache, Drowsiness, Insomnia, Hallucinations, Depression, Confusion, Peripheral neuropathy, Numbness of the extremities, Tingling of the extremities, Urethral discomfort, Darkening of the urine, Raised liver enzyme values, Cholestatic hepatitis, Jaundice, Pancreatitis, Thrombophlebitis
Ref :-   Book : Martindale    Page : 924,937   Edition : 37.  

►  Drug Interaction : Drug interaction of Tinidazole is with Alcohol, , ,  Warfarin , Phenytoin , Fluorouracil , Phenobarbital , Cimetidine
Ref :-   Book : Martindale    Page : 925, 397   Edition : 37.  


  ►    Mechanism of Drug Drug Interaction :  Tinidazole may, produce a disulfiram-like reaction with alcohol. Tinidazole is reported to impair the metabolism or excretion of several drugs including coumarins and warfarin, phenytoin, lithium, ciclosporin, and fluorouracil, with the consequent potential for an increased incidence of adverse effects. There is some evidence that phenytoin might accelerate the elimination of tinidazole. Plasma concentrations of tinidazole are decreased by phenobarbital, with a consequent reduction in the effectiveness of tinidazole. Cimetidine has increased plasma concentrations of tinidazole.
Ref :-   Book : Martindale    Page : 925,397   Edition : 37.  


►  Contraindication : Hepatic impairment, First trimester of Pregnancy, Tinidazole should be used with caution in patients with blood dyscrasias or CNS disesase; it should be stopped in those who develop abnormal neurological signs.
Ref :-   Book : Martindale    Page : 925,937   Edition : 37.  
  ►  Mechanism of Action :   In obligate anaerobic microorganisms (but not in aerobic microorganisms, which it also enters) tinidazole is converted into an active form by reduction of its nitro group: this binds to DNA and prevents nucleic acid formation; it is bacteriostatic.
Ref :-   Book : Clinical Pharmacology    Page : 233   Edition : 9.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eucalyptus oil with .  

  ►  Pathway with its reference as follows :-
  • Eucalyotol have antibiotic effect --- ( Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan. )

  •   ►  URL --
  • https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152 .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal
    Ref :-   Book : Martindale    Page : 937   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   14 hours.  
    Ref :-   Book : Martindale    Page : 937   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book :    Page : 937   Edition : 37.