Tiopronin is a Medicine belongs to Chelators group whose information about Brand can be referenced from   Book : Martindale    Page : 1610   Edition : 37,

  ►   Brandname : Captimer, Thiola

  ►  Strength : Injection with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1609   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, inhalation,
Reference :-   Book : Martindale    Page : 1609   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Management of cystinuria, in conjunction with adequate hydration and alkalinisation of the urine Oral 0.8 1 gm Tablet Dose: Given daily in divided doses. The dose should be adjusted according to the urinary cystine concentration; up to 2 g daily has been given. Tiopronin should be given on an empty stomach. Tiopronin is used in similar doses in rheumatoid arthritis.

Ref :-  Book : Martindale    Page : 1609   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition : ,
►  Side Effect : Gastrointestinal disturbances, anorexia, nausea, vomiting, oral ulceration, stomatitis, Impaired taste sensitivity, Skin rashes, pruritus, Urticaria, fever, lupus erythematosus, pemphigus, Stevens-Johnson like syndrome, thrombocytopenia, leukopenia, agranulocytosis, aplastic anaemia, fatalities, Hemolytic anemia, proteinuria, Goodpasture’s syndrome, bronchiolitis, pneumonitis, myasthenia gravis, intrahepatic cholestasis, Pancreatitis, ,
Ref :-   Book : Martindale    Page : 1598,1609   Edition : 37,

►  Drug Interaction : Drug interaction of Tiopronin is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : lupus erythematosus, History of tiopronin-induced agranulocytosis, aplastic anaemia, or severe thrombocytopenia, Moderate or severe renal impairment, Thyrotrophin should not be given to patients with recent myocardial infarction or uncorrected adrenocortical insufficiency, including adrenocortical insufficiency secondary to hypopituitarism. Care is also required in patients with cardiovascular disease.,
Ref :-   Book : Martindale    Page : 1599, 1609   Edition : 37,
  ►  Mechanism of Action :   Tiopronin is a chelator that aids the elimination from the body of certain heavy-metal ions, including copper, lead, and mercury, by forming stable soluble complexes with them that are readily excreted by the kidney. ,
Ref :-   Book : Martindale    Page : 1600   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cilantro with Another pathway, Garlic with Another pathway, Raw apple with Another pathway, Banana with Another pathway, Grapes with Another pathwayAnother pathway, Grapes with Another pathwayAnother pathway,

  ►  Pathway with its reference as follows :-
  • Natural Chelation --- ( E, M. (2013). Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review. The Scientific World Journal. )
  • Garlic-Sulphur compound is a Natural Chelation --- ( Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review. The Scientific World Journal. http://dx.doi.org/10.1155/2013/219840 )
  • Raw apples- Malic acid is a Natural Chelation --- ( E, M. (2013). Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review. The Scientific World Journal. http://dx.doi.org/10.1155/2013/219840 )
  • Natural Chelation --- ( Y, H. (2010). Radical scavenging and antioxidant activity of tannic acid. Arabian Journal Of Chemistry, 3(1). )
  • Tannic acid act as Natural Chelation --- ( Y, H. (2010). Radical scavenging and antioxidant activity of tannic acid. Arabian Journal Of Chemistry, 3(1). )
  • Tannic acid act as Natural Chelation --- (Y, H. (2010). Radical scavenging and antioxidant activity of tannic acid. Arabian Journal Of Chemistry, 3(1). )
  • Tannic acid act as Natural Chelation --- ( Y, H. (2010). Radical scavenging and antioxidant activity of tannic acid. Arabian Journal Of Chemistry, 3(1). )
  • Tannic acid act as Natural Chelation --- (Y, H. (2010). Radical scavenging and antioxidant activity of tannic acid. Arabian Journal Of Chemistry, 3(1). )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654245/, www.ncbi.nlm.nih.gov/pmc/articles/PMC3654245/, http://www.sciencedirect.com/science/article/pii/S187853520900046X,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1578   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 1578   Edition : 38,