Tiotropium Bromide is a Medicine belongs to Antimuscarinic Anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 1264   Edition : 37      Page :   Edition :   

  ►   Brandname : Spiriva, Tiova, Tiate MDI
  ►  Strength : Aerosol with 18 mcg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 127   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation
Reference :-   Book : Martindale    Page : 1264   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Reversible airway obstruction, as in chronic obstructive pulmonary disease inhalation 22.5 micrograms Aerosol Dose: given as inhalation powder in capsules containing 22.5 micrograms of tiotropium bromide monohydrate, equivalent to 18 micrograms of tiotropium, and supplying 10 micrograms of tiotropium from the mouthpiece of the inhaler device. The contents of one capsule are inhaled daily, at the same time each day.

Ref :-  Book : Martindale    Page : 1264   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :    Page :    Edition :   
►  Side Effect : Dry mouth, Constipation, Acute angle-closure glaucoma, Paradoxical bronchospasm, Tachycardia, palpitations, Arrhythmias, Nausea, Vomiting, Dyspepsia, Headache, Dizziness, Pharyngitis, sinusitis, rhinitis, and epistaxis have also been reported after inhalation.
Ref :-   Book : Martindale    Page : 1237,1264   Edition : 37.  

►  Drug Interaction : Drug interaction of Tiotropium Bromide is with NA

  ►    Mechanism of Drug Drug Interaction :  Interactions are not usually seen with antimuscarinics, such as tiotropium, given by inhalation.
Ref :-   Book : Martindale    Page : 1264   Edition : 37.  

►  Contraindication : Prostatic enlargement, Paralytic ileus, Pyloric stenosis, Diarrhoea, Angle-closure glaucoma, Hypersensitivity, Hypersensitivity to soya lecithin or related food products
Ref :-   Book : Martindale    Page : 1237,1264,1343   Edition : 37.   Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 384   Edition : 3.  
  ►  Mechanism of Action :   Antagonists at muscarinic receptors on airway smooth muscle and glands, leading to decreased bronchoconstriction and mucus secretion
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 834   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Adhatoda vasica Nees i. e. malabar nut with Another pathway.   Albizzia lebbeck with Another pathway.   Alstonia scholaris with Another pathway.   Artemisia caerulescens with Another pathway.   Belamcand chinensis with Another pathway.   Benincasa hispida with Another pathway.   Cissampelos sympodialis with Another pathway.   Clerodendrum serratum with Another pathway.   Coleus forskohlii i.e. makandi with Another pathway.   Elaeocarpus spharicus with Another pathway.   Galphimia glauca with Another pathway.   Gardenia latifolia with Another pathway.   Ginkgo biloba with Another pathway.   Mikania glomerata with Another pathway.   Mikania glomerata with Another pathway.   Lepidium sativum with Another pathway.   Tulsi with Another pathway.   Passiflora incarnata with Another pathway.   Pavetta crassipes with Another pathway.   Pichorhiza i e Kutki with Another pathway.   Sarcostemm brevistigma with Another pathway.   Tephrosia purpurea with Another pathway.   Tylophora indica with Another pathway.   Vitexin with Another pathway.   Rosmarinus officinalis with Another pathway.   Ephedra sinica with Another pathway.   Gleditsia sinensis with Another pathway.  

  ►  Pathway with its reference as follows :-
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )

  •   ►  URL --
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245822/ .

  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1264   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   5 days,    Max value :-   6 days.  
    Ref :-   Book : Martindale    Page : 1264   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA