Tirofiban is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1552   Edition : 37  

  ►   Brandname : Aggrastat
  ►  Strength : Injection with 50 mcg/ml.  Injection with 250 mcg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion
Reference :-   Book : Basic & Clinical pharmacology    Page : 617   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Unstable angina, both in patients managed medically and in those undergoing percutaneous coronary procedures IV infusion 400 nanograms/kg per minute Injection Given for 30 minutes, and then continued at 100 nanograms/kg per minute. The recommended duration of treatment is at least 48 hours. Tirofiban infusion may be continued during coronary angiography, and should be maintained for 12 to 24 hours after angioplasty or atherectomy. The entire duration of treatment should not exceed 108 hours.

Ref :-  Book : Martindale    Page : 1552   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book :    Page :    Edition :   
►  Side Effect : Bleeding, Nausea, Headache, Fever, Rashes, Hypersensitivity reactions, Thrombocytopenia
Ref :-   Book : Martindale    Page : 1552   Edition : 37.  

►  Drug Interaction : Drug interaction of Tirofiban is with NA

  ►    Mechanism of Drug Drug Interaction :  N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : History of bleeding diathesis or recent abnormal bleeding, Concomitent administration of a second glycoprotein IIb-IIIa antagonist, Recent major surgery, Recent stroke or history of hemorrhagic stroke, Intracranial hemorrhage, mass, or arteriovenous malformation, Severe uncontrolled hypertension
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 396   Edition : 3.  
  ►  Mechanism of Action :   Bind to platelet receptor GPIIb/IIIa and thereby prevent binding of fibrinogen and other adhesive ligands
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 396   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


DIETARY Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication DIETARY Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Biliary, Fecal, Renal
Ref :-   Book : Martindale    Page : 1552   Edition : 37.  

►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1552   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .