Tizanidine is a Medicine belongs to Muscle relaxants group whose information about Brand can be referenced from   Book : Martindale    Page : 2063   Edition : 37,

  ►   Brandname : Sirdalud,Zanaflex

  ►  Strength : Capsule with 2  mg, Capsule with 4  mg, Capsule with 6  mg, Tablet with 2  mg, Tablet with 4  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 481   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2063   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Spasticity Oral 2 mg Tablet o.d.
2 painful muscle spasm Oral 2 4 mg Tablet t.i.d.

Ref :-  Book : Martindale    Page : 2063   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : dry mouth, fatigue, Dizziness, vertigo, muscle pain, weakness, insomnia, anxiety, headache, bradycardia, nausea, gastrointestinal disturbance, hallucinations, hypotension,
Ref :-   Book : Martindale    Page : 2062   Edition : 37,

►  Drug Interaction : Drug interaction of Tizanidine is with Ciprofloxacin , Fluvoxamine, Glipizide , Cimetidine , Abatacept , Mexiletine , Propafenone, Verapamil , Phentolamine , Mivacurium Chloride , Voglibose , Ciprofloxacin , Fluvoxamine, Phenytoin , Lisinopril , Ethinylestradiol , Gestodene ,
Ref :-   Book : Martindale    Page : 544,2062   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Tizanidine is metabolised by the cytochrome P450 isoenzyme CYP1A2 and use with ciprofloxacin or fluvoxamine, both potent inhibitors of this isoenzyme, is contra-indicated. The CNS effects of tizanidine may be enhanced by alcohol or other CNS depressants. There may be an additive hypotensive effect when tizanidine is used in patients receiving antihypertensive therapy; bradycardia may also be enhanced if given with beta blockers or digoxin. The clearance of tizanidine has been reported to be lower in women receiving hormonal contraceptives. Ciprofloxacin, an inhibitor of the cytochrome P450 isoenzyme CYP1A2, was reported to elevate the plasma concentrations of tizanidine thereby potentiating its hypotensive and sedative effects. Fluvoxamine, a potent inhibitor of the cytochrome P450 isoenzyme CYP1A2, was reported to increase tizanidine’s peak plasma concentrations and elimination half-life 12-fold and 3-fold, respectively. An increase in serum concentrations of phenytoin has been reported in a patient when tizanidine was added to therapy. Severe hypotension, occurring 2 hours after treatment with tizanidine, has been reported in a patient receiving antihypertensives, including lisinopril, and other medications. Severe hypotension, occurring 2 hours after treatment with tizanidine, has been reported in a patient receiving antihypertensives, including lisinopril, and other medications. Mean peak plasma concentrations after a single 4-mg dose of tizanidine were 3 times greater in 15 women using an oral contraceptive containing ethinylestradiol and gestodene than in controls.,
Ref :-   Book : Martindale    Page : 2062   Edition : 37,


►  Contraindication : hepatic dysfunction,
Ref :-   Book : Martindale    Page : 2062   Edition : 37,
  ►  Mechanism of Action :   Tizanidine hydrochloride is a centrally acting skeletal muscle relaxant. It is an α2-adrenergic agonist structurally related to clonidine and acts mainly at spinal and supraspinal levels to inhibit excitatory interneurones,
Ref :-   Book : Martindale    Page : 2063   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- with 5-HTP cause excessive drawsiness when taken with muscle relaxcent .,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 2063   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 2063   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 2063   Edition : 37,